RBM25 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042981Biological processregulation of apoptotic process
GO_0008380Biological processRNA splicing
GO_0006397Biological processmRNA processing
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameRBM25
Protein nameAlternative protein RBM25
RNA binding motif protein 25
RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7)
SynonymsRNPC7
DescriptionFUNCTION: RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. .

AccessionsENST00000526754.5 [P49756-2]
ENST00000527432.5 [P49756-1]
E9PQU5
ENST00000531500.5
H0YE46
L8EB35
E9PSE8
ENST00000261973.12 [P49756-1]
P49756
ENST00000532192.1
ENST00000525321.5 [P49756-3]
ENST00000525161.5
ENST00000528081.5 [P49756-4]