PPP1CA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030324Biological processlung development
GO_0006470Biological processprotein dephosphorylation
GO_0005979Biological processregulation of glycogen biosynthetic process
GO_0048754Biological processbranching morphogenesis of an epithelial tube
GO_0005977Biological processglycogen metabolic process
GO_0010288Biological processresponse to lead ion
GO_0051301Biological processcell division
GO_0032922Biological processcircadian regulation of gene expression
GO_0042752Biological processregulation of circadian rhythm
GO_0005981Biological processregulation of glycogen catabolic process
GO_0006446Biological processregulation of translational initiation
GO_0016311Biological processdephosphorylation
GO_0043247Biological processtelomere maintenance in response to DNA damage
GO_0043153Biological processentrainment of circadian clock by photoperiod
GO_2001241Biological processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_0098609Biological processcell-cell adhesion
GO_0060828Biological processregulation of canonical Wnt signaling pathway
GO_0098978Cellular componentglutamatergic synapse
GO_0005730Cellular componentnucleolus
GO_0098793Cellular componentpresynapse
GO_0005886Cellular componentplasma membrane
GO_0043197Cellular componentdendritic spine
GO_0042587Cellular componentglycogen granule
GO_0043204Cellular componentperikaryon
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005912Cellular componentadherens junction
GO_0005737Cellular componentcytoplasm
GO_0072357Cellular componentPTW/PP1 phosphatase complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0005634Cellular componentnucleus
GO_0004721Molecular functionphosphoprotein phosphatase activity
GO_0017018Molecular functionmyosin phosphatase activity
GO_0043021Molecular functionribonucleoprotein complex binding
GO_0008157Molecular functionprotein phosphatase 1 binding
GO_0098641Molecular functioncadherin binding involved in cell-cell adhesion
GO_0046872Molecular functionmetal ion binding
GO_0004722Molecular functionprotein serine/threonine phosphatase activity
GO_0016791Molecular functionphosphatase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePPP1CA
Protein nameSerine/threonine-protein phosphatase (EC 3.1.3.16)
Protein phosphatase 1, catalytic subunit, alpha
Protein phosphatase 1, catalytic subunit, alpha isoform
protein-serine/threonine phosphatase (EC 3.1.3.16)
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
SynonymsPPP1A
DescriptionFUNCTION: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective . Dephosphorylates CENPA . Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy . .; FUNCTION: (Microbial infection) Necessary for alphaviruses replication. .

AccessionsC0STL0
P62136
ENST00000679175.1
C4TNW5
C4TNW6
ENST00000376745.9 [P62136-1]
ENST00000312989.11 [P62136-2]
E9PMD7
ENST00000527663.6
A0A7I2V4F7
ENST00000358239.8 [P62136-3]