POLR2L | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	38 studies	56% ± 20%	Explore
natural killer cell	37 studies	53% ± 14%	Explore
fibroblast	37 studies	52% ± 20%	Explore
B cell	35 studies	35% ± 13%	Explore
macrophage	35 studies	49% ± 16%	Explore
CD8-positive, alpha-beta T cell	33 studies	46% ± 15%	Explore
pericyte	31 studies	50% ± 17%	Explore
T cell	30 studies	45% ± 13%	Explore
CD4-positive, alpha-beta T cell	30 studies	42% ± 12%	Explore
conventional dendritic cell	27 studies	54% ± 15%	Explore
smooth muscle cell	25 studies	50% ± 14%	Explore
classical monocyte	24 studies	57% ± 13%	Explore
non-classical monocyte	23 studies	48% ± 14%	Explore
regulatory T cell	23 studies	42% ± 11%	Explore
dendritic cell	22 studies	48% ± 21%	Explore
endothelial cell of lymphatic vessel	22 studies	78% ± 13%	Explore
epithelial cell	22 studies	58% ± 22%	Explore
plasma cell	21 studies	51% ± 18%	Explore
mature NK T cell	21 studies	42% ± 14%	Explore
mast cell	20 studies	36% ± 15%	Explore
monocyte	20 studies	50% ± 18%	Explore
plasmacytoid dendritic cell	20 studies	49% ± 14%	Explore
basal cell	20 studies	59% ± 19%	Explore
memory B cell	19 studies	35% ± 10%	Explore
connective tissue cell	19 studies	53% ± 21%	Explore
gamma-delta T cell	18 studies	47% ± 16%	Explore
ciliated cell	16 studies	66% ± 19%	Explore
naive B cell	16 studies	27% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	48% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	51% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	35% ± 9%	Explore
capillary endothelial cell	14 studies	47% ± 16%	Explore
mucosal invariant T cell	14 studies	38% ± 13%	Explore
myofibroblast cell	13 studies	52% ± 14%	Explore
myeloid cell	13 studies	52% ± 20%	Explore
secretory cell	12 studies	57% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	44% ± 11%	Explore
endothelial cell of artery	12 studies	49% ± 18%	Explore
vein endothelial cell	12 studies	59% ± 16%	Explore
plasmablast	11 studies	60% ± 21%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	47% ± 13%	Explore
goblet cell	11 studies	50% ± 22%	Explore
endothelial cell of vascular tree	11 studies	53% ± 16%	Explore
innate lymphoid cell	10 studies	51% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	40% ± 14%	Explore
progenitor cell	10 studies	61% ± 19%	Explore
abnormal cell	10 studies	48% ± 15%	Explore
mesothelial cell	10 studies	72% ± 19%	Explore
type I pneumocyte	9 studies	67% ± 19%	Explore
type II pneumocyte	9 studies	69% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	44% ± 12%	Explore
club cell	8 studies	67% ± 18%	Explore
leukocyte	8 studies	42% ± 15%	Explore
IgG plasma cell	8 studies	38% ± 15%	Explore
T follicular helper cell	8 studies	43% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	55% ± 15%	Explore
epithelial cell of proximal tubule	7 studies	61% ± 18%	Explore
neuron	7 studies	42% ± 23%	Explore
enterocyte	7 studies	51% ± 19%	Explore
IgA plasma cell	7 studies	35% ± 14%	Explore
respiratory goblet cell	6 studies	55% ± 20%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	45% ± 15%	Explore
kidney loop of Henle epithelial cell	6 studies	64% ± 11%	Explore
neutrophil	6 studies	35% ± 10%	Explore
renal alpha-intercalated cell	6 studies	74% ± 5%	Explore
enteroendocrine cell	6 studies	72% ± 25%	Explore
erythroblast	6 studies	46% ± 28%	Explore
transit amplifying cell	6 studies	50% ± 30%	Explore
erythrocyte	6 studies	52% ± 23%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	44% ± 12%	Explore
alveolar macrophage	5 studies	48% ± 9%	Explore
hematopoietic precursor cell	5 studies	44% ± 23%	Explore
exhausted T cell	5 studies	52% ± 10%	Explore
ionocyte	5 studies	49% ± 12%	Explore
mononuclear phagocyte	5 studies	63% ± 10%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	72% ± 13%	Explore
precursor B cell	5 studies	41% ± 14%	Explore
intermediate monocyte	5 studies	70% ± 10%	Explore
hepatocyte	5 studies	52% ± 35%	Explore
granulocyte	5 studies	37% ± 12%	Explore
deuterosomal cell	4 studies	62% ± 24%	Explore
duct epithelial cell	4 studies	75% ± 7%	Explore
pancreatic A cell	4 studies	72% ± 20%	Explore
type B pancreatic cell	4 studies	62% ± 21%	Explore
glomerular endothelial cell	4 studies	50% ± 15%	Explore
intestinal crypt stem cell	4 studies	49% ± 20%	Explore
microglial cell	4 studies	37% ± 14%	Explore
retinal ganglion cell	4 studies	54% ± 27%	Explore
hematopoietic stem cell	4 studies	46% ± 9%	Explore
lymphocyte	4 studies	77% ± 10%	Explore
megakaryocyte	4 studies	35% ± 3%	Explore
brush cell	4 studies	42% ± 19%	Explore
immature B cell	4 studies	43% ± 14%	Explore
amacrine cell	4 studies	36% ± 18%	Explore
astrocyte	4 studies	41% ± 16%	Explore
adventitial cell	4 studies	57% ± 6%	Explore
mucus secreting cell	4 studies	62% ± 20%	Explore
endothelial cell of sinusoid	4 studies	39% ± 17%	Explore
muscle cell	4 studies	39% ± 17%	Explore
germinal center B cell	4 studies	45% ± 17%	Explore
CD4-positive helper T cell	4 studies	37% ± 11%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	73% ± 11%	Explore
luminal cell of prostate epithelium	4 studies	53% ± 21%	Explore
glial cell	4 studies	44% ± 22%	Explore
group 3 innate lymphoid cell	4 studies	59% ± 11%	Explore
melanocyte	4 studies	64% ± 22%	Explore
T-helper 17 cell	4 studies	55% ± 10%	Explore
T-helper 1 cell	4 studies	57% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	44% ± 11%	Explore
precursor cell	3 studies	65% ± 10%	Explore
platelet	3 studies	31% ± 15%	Explore
podocyte	3 studies	75% ± 8%	Explore
neural crest cell	3 studies	56% ± 5%	Explore
retinal bipolar neuron	3 studies	49% ± 24%	Explore
renal principal cell	3 studies	65% ± 4%	Explore
thymocyte	3 studies	37% ± 20%	Explore
extravillous trophoblast	3 studies	43% ± 21%	Explore
placental villous trophoblast	3 studies	72% ± 19%	Explore
common myeloid progenitor	3 studies	45% ± 20%	Explore
pro-B cell	3 studies	38% ± 2%	Explore
neuroendocrine cell	3 studies	73% ± 21%	Explore
retina horizontal cell	3 studies	42% ± 16%	Explore
retinal cone cell	3 studies	74% ± 18%	Explore
retinal pigment epithelial cell	3 studies	60% ± 28%	Explore
retinal rod cell	3 studies	45% ± 14%	Explore
serous secreting cell	3 studies	77% ± 14%	Explore
intraepithelial lymphocyte	3 studies	54% ± 8%	Explore
Mueller cell	3 studies	57% ± 10%	Explore
acinar cell	3 studies	51% ± 17%	Explore
cardiac muscle cell	3 studies	31% ± 9%	Explore
oligodendrocyte	3 studies	19% ± 4%	Explore
myoepithelial cell	3 studies	50% ± 6%	Explore
inflammatory macrophage	3 studies	50% ± 13%	Explore
IgM plasma cell	3 studies	42% ± 13%	Explore
oligodendrocyte precursor cell	3 studies	32% ± 12%	Explore
granulocyte monocyte progenitor cell	3 studies	46% ± 29%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	49% ± 26%	Explore
keratinocyte	3 studies	69% ± 10%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	40% ± 12%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	40% ± 14%	Explore
double negative thymocyte	3 studies	58% ± 13%	Explore
progenitor cell of mammary luminal epithelium	3 studies	45% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	19 studies	45% ± 12%	Explore
lung	18 studies	56% ± 14%	Explore
intestine	13 studies	44% ± 20%	Explore
kidney	9 studies	52% ± 12%	Explore
eye	8 studies	41% ± 17%	Explore
liver	8 studies	46% ± 25%	Explore
lymph node	6 studies	43% ± 11%	Explore
brain	6 studies	29% ± 9%	Explore
pancreas	5 studies	57% ± 23%	Explore
bone marrow	5 studies	34% ± 12%	Explore
uterus	5 studies	56% ± 23%	Explore
placenta	4 studies	50% ± 22%	Explore
prostate	4 studies	46% ± 9%	Explore
breast	4 studies	53% ± 9%	Explore
adipose	3 studies	28% ± 12%	Explore
adrenal gland	3 studies	47% ± 6%	Explore
esophagus	3 studies	59% ± 25%	Explore
skin	3 studies	50% ± 23%	Explore
thymus	3 studies	54% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3755.84	1445 / 1445	100%	155.58	183 / 183
liver	100%	2963.00	226 / 226	100%	262.79	406 / 406
ovary	100%	2034.91	180 / 180	100%	338.68	430 / 430
thymus	100%	4207.54	653 / 653	100%	326.74	605 / 605
uterus	100%	2552.75	170 / 170	100%	288.55	457 / 459
intestine	100%	3069.07	966 / 966	99%	257.33	523 / 527
prostate	100%	3582.91	245 / 245	99%	302.40	498 / 502
brain	99%	2281.60	2624 / 2642	100%	185.60	704 / 705
skin	100%	5426.59	1809 / 1809	99%	373.66	468 / 472
pancreas	100%	3222.07	327 / 328	99%	233.21	177 / 178
adrenal gland	100%	4972.10	258 / 258	99%	225.15	228 / 230
stomach	100%	2732.33	359 / 359	99%	217.79	283 / 286
breast	100%	5078.52	459 / 459	99%	288.49	1104 / 1118
kidney	100%	4894.55	89 / 89	99%	187.53	889 / 901
bladder	100%	3369.29	21 / 21	98%	269.34	496 / 504
lung	100%	4038.82	576 / 578	98%	216.79	1136 / 1155
adipose	100%	5879.50	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	454.81	80 / 80
lymph node	0%	0	0 / 0	100%	362.16	29 / 29
spleen	100%	3637.42	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	220.60	45 / 45
ureter	0%	0	0 / 0	100%	321.60	1 / 1
muscle	100%	3834.21	799 / 803	0%	0	0 / 0
blood vessel	99%	3018.91	1328 / 1335	0%	0	0 / 0
heart	99%	5429.34	854 / 861	0%	0	0 / 0
peripheral blood	91%	1774.75	843 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006366	Biological process	transcription by RNA polymerase II
GO_0042797	Biological process	tRNA transcription by RNA polymerase III
GO_0006360	Biological process	transcription by RNA polymerase I
GO_0006356	Biological process	regulation of transcription by RNA polymerase I
GO_0005736	Cellular component	RNA polymerase I complex
GO_0005665	Cellular component	RNA polymerase II, core complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005666	Cellular component	RNA polymerase III complex
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0001055	Molecular function	RNA polymerase II activity
GO_0001056	Molecular function	RNA polymerase III activity
GO_0001054	Molecular function	RNA polymerase I activity
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding
GO_0003899	Molecular function	DNA-directed 5'-3' RNA polymerase activity

Gene name	POLR2L
Protein name	DNA-directed RNA polymerases I, II, and III subunit RPABC5 (RNA polymerases I, II, and III subunit ABC5) (DNA-directed RNA polymerase III subunit L) (RNA polymerase II 7.6 kDa subunit) (RPB7.6) (RPB10 homolog)
Synonyms
Description	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. .
Accessions	ENST00000534030.1 ENST00000322028.5 P62875

POLR2L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review