PEBP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043409Biological processnegative regulation of MAPK cascade
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0004867Molecular functionserine-type endopeptidase inhibitor activity
GO_0008429Molecular functionphosphatidylethanolamine binding
GO_0019901Molecular functionprotein kinase binding
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene namePEBP1
Protein namePhosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)]
SynonymsPEBP
PBP
DescriptionFUNCTION: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. .; FUNCTION: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). .

AccessionsENST00000261313.3
P30086