MT-CO3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	51 studies	92% ± 17%	Explore
macrophage	46 studies	87% ± 21%	Explore
endothelial cell	45 studies	82% ± 23%	Explore
natural killer cell	44 studies	93% ± 14%	Explore
fibroblast	42 studies	84% ± 26%	Explore
T cell	39 studies	93% ± 13%	Explore
CD8-positive, alpha-beta T cell	37 studies	91% ± 16%	Explore
pericyte	36 studies	85% ± 23%	Explore
CD4-positive, alpha-beta T cell	35 studies	88% ± 19%	Explore
smooth muscle cell	32 studies	85% ± 23%	Explore
conventional dendritic cell	31 studies	95% ± 13%	Explore
mast cell	29 studies	80% ± 25%	Explore
dendritic cell	28 studies	88% ± 19%	Explore
plasmacytoid dendritic cell	27 studies	94% ± 9%	Explore
monocyte	26 studies	91% ± 17%	Explore
plasma cell	26 studies	86% ± 20%	Explore
endothelial cell of lymphatic vessel	26 studies	89% ± 17%	Explore
classical monocyte	25 studies	94% ± 12%	Explore
regulatory T cell	25 studies	95% ± 11%	Explore
non-classical monocyte	24 studies	91% ± 19%	Explore
epithelial cell	23 studies	89% ± 16%	Explore
mature NK T cell	22 studies	92% ± 13%	Explore
gamma-delta T cell	21 studies	95% ± 9%	Explore
basal cell	21 studies	90% ± 15%	Explore
memory B cell	20 studies	98% ± 4%	Explore
mucosal invariant T cell	18 studies	91% ± 17%	Explore
connective tissue cell	18 studies	88% ± 21%	Explore
ciliated cell	17 studies	87% ± 14%	Explore
naive B cell	17 studies	97% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	90% ± 18%	Explore
capillary endothelial cell	16 studies	83% ± 21%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	85% ± 24%	Explore
neutrophil	15 studies	78% ± 22%	Explore
endothelial cell of artery	15 studies	88% ± 11%	Explore
erythrocyte	15 studies	72% ± 24%	Explore
microglial cell	15 studies	69% ± 25%	Explore
innate lymphoid cell	14 studies	93% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	96% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	90% ± 17%	Explore
astrocyte	14 studies	65% ± 24%	Explore
vein endothelial cell	14 studies	81% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	86% ± 20%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	94% ± 11%	Explore
endothelial cell of vascular tree	13 studies	88% ± 20%	Explore
myeloid cell	13 studies	82% ± 24%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	94% ± 11%	Explore
myofibroblast cell	12 studies	95% ± 8%	Explore
mesothelial cell	12 studies	85% ± 18%	Explore
plasmablast	11 studies	97% ± 2%	Explore
secretory cell	11 studies	95% ± 9%	Explore
oligodendrocyte	11 studies	56% ± 22%	Explore
goblet cell	11 studies	92% ± 20%	Explore
type I pneumocyte	10 studies	77% ± 25%	Explore
glutamatergic neuron	10 studies	72% ± 24%	Explore
oligodendrocyte precursor cell	10 studies	54% ± 27%	Explore
leukocyte	10 studies	89% ± 18%	Explore
IgG plasma cell	10 studies	83% ± 16%	Explore
type II pneumocyte	9 studies	82% ± 22%	Explore
platelet	9 studies	78% ± 23%	Explore
T follicular helper cell	9 studies	97% ± 3%	Explore
club cell	9 studies	78% ± 22%	Explore
respiratory goblet cell	9 studies	85% ± 17%	Explore
IgA plasma cell	9 studies	80% ± 20%	Explore
hematopoietic stem cell	9 studies	96% ± 7%	Explore
progenitor cell	8 studies	97% ± 2%	Explore
neuron	8 studies	81% ± 21%	Explore
alveolar macrophage	7 studies	94% ± 8%	Explore
mononuclear phagocyte	7 studies	94% ± 6%	Explore
GABAergic neuron	7 studies	66% ± 26%	Explore
epithelial cell of proximal tubule	7 studies	78% ± 28%	Explore
enterocyte	7 studies	98% ± 1%	Explore
enteroendocrine cell	7 studies	96% ± 5%	Explore
brush cell	7 studies	83% ± 26%	Explore
glial cell	7 studies	84% ± 16%	Explore
adipocyte	7 studies	57% ± 24%	Explore
CD4-positive helper T cell	6 studies	90% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	78% ± 27%	Explore
hematopoietic precursor cell	6 studies	85% ± 28%	Explore
ionocyte	6 studies	96% ± 4%	Explore
hepatocyte	6 studies	76% ± 26%	Explore
interneuron	6 studies	69% ± 30%	Explore
kidney loop of Henle epithelial cell	6 studies	67% ± 36%	Explore
renal alpha-intercalated cell	6 studies	97% ± 3%	Explore
abnormal cell	6 studies	94% ± 3%	Explore
erythroblast	6 studies	74% ± 27%	Explore
transit amplifying cell	6 studies	86% ± 21%	Explore
lymphocyte	6 studies	75% ± 32%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	98% ± 2%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	97% ± 6%	Explore
melanocyte	6 studies	85% ± 28%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	92% ± 14%	Explore
cholangiocyte	5 studies	77% ± 23%	Explore
podocyte	5 studies	77% ± 31%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	98% ± 1%	Explore
megakaryocyte	5 studies	93% ± 4%	Explore
OFF-bipolar cell	5 studies	78% ± 33%	Explore
ON-bipolar cell	5 studies	82% ± 31%	Explore
retinal cone cell	5 studies	75% ± 27%	Explore
retinal rod cell	5 studies	72% ± 24%	Explore
Mueller cell	5 studies	62% ± 31%	Explore
inflammatory macrophage	5 studies	94% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	95% ± 9%	Explore
immature B cell	5 studies	100% ± 1%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	78% ± 24%	Explore
deuterosomal cell	4 studies	89% ± 1%	Explore
duct epithelial cell	4 studies	93% ± 4%	Explore
exhausted T cell	4 studies	95% ± 5%	Explore
kidney connecting tubule epithelial cell	4 studies	92% ± 14%	Explore
intestinal crypt stem cell	4 studies	99% ± 2%	Explore
paneth cell	4 studies	98% ± 2%	Explore
retinal ganglion cell	4 studies	94% ± 8%	Explore
precursor B cell	4 studies	99% ± 1%	Explore
adventitial cell	4 studies	91% ± 14%	Explore
mucus secreting cell	4 studies	46% ± 14%	Explore
cardiac muscle cell	4 studies	34% ± 18%	Explore
amacrine cell	4 studies	92% ± 10%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	98% ± 2%	Explore
granulocyte	4 studies	84% ± 13%	Explore
IgM plasma cell	4 studies	85% ± 13%	Explore
intermediate monocyte	4 studies	94% ± 8%	Explore
keratinocyte	4 studies	96% ± 3%	Explore
T-helper 17 cell	4 studies	99% ± 1%	Explore
T-helper 1 cell	4 studies	98% ± 1%	Explore
double negative thymocyte	4 studies	99% ± 1%	Explore
Langerhans cell	3 studies	94% ± 7%	Explore
precursor cell	3 studies	89% ± 11%	Explore
squamous epithelial cell	3 studies	76% ± 22%	Explore
endothelial cell of sinusoid	3 studies	96% ± 4%	Explore
hepatic stellate cell	3 studies	89% ± 5%	Explore
glomerular endothelial cell	3 studies	98% ± 1%	Explore
parietal epithelial cell	3 studies	71% ± 39%	Explore
neural crest cell	3 studies	99% ± 1%	Explore
GABAergic amacrine cell	3 studies	88% ± 9%	Explore
glycinergic amacrine cell	3 studies	91% ± 9%	Explore
renal principal cell	3 studies	99% ± 1%	Explore
thymocyte	3 studies	99% ± 1%	Explore
pro-B cell	3 studies	99% ± 1%	Explore
neuroendocrine cell	3 studies	98% ± 1%	Explore
serous secreting cell	3 studies	55% ± 11%	Explore
follicular B cell	3 studies	98% ± 1%	Explore
intraepithelial lymphocyte	3 studies	99% ± 1%	Explore
rod bipolar cell	3 studies	72% ± 37%	Explore
myoepithelial cell	3 studies	99% ± 1%	Explore
luminal cell of prostate epithelium	3 studies	100% ± 0%	Explore
retina horizontal cell	3 studies	91% ± 7%	Explore
retinal pigment epithelial cell	3 studies	58% ± 24%	Explore
muscle cell	3 studies	68% ± 14%	Explore
ependymal cell	3 studies	52% ± 16%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	98% ± 2%	Explore
germinal center B cell	3 studies	88% ± 5%	Explore
group 3 innate lymphoid cell	3 studies	99% ± 0%	Explore
Schwann cell	3 studies	77% ± 27%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	97% ± 2%	Explore
double-positive, alpha-beta thymocyte	3 studies	99% ± 1%	Explore
progenitor cell of mammary luminal epithelium	3 studies	96% ± 1%	Explore
mural cell	3 studies	81% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	83% ± 19%	Explore
peripheral blood	17 studies	94% ± 10%	Explore
brain	14 studies	66% ± 25%	Explore
intestine	13 studies	89% ± 22%	Explore
kidney	8 studies	75% ± 31%	Explore
eye	7 studies	77% ± 23%	Explore
liver	6 studies	91% ± 6%	Explore
bone marrow	5 studies	96% ± 3%	Explore
heart	5 studies	44% ± 18%	Explore
lymph node	4 studies	98% ± 1%	Explore
breast	4 studies	97% ± 1%	Explore
uterus	3 studies	99% ± 1%	Explore
prostate	3 studies	100% ± 0%	Explore
esophagus	3 studies	90% ± 2%	Explore
skin	3 studies	97% ± 1%	Explore
adipose	3 studies	95% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	1384054.70	257 / 258	100%	55134.60	230 / 230
kidney	100%	2875763.90	89 / 89	99%	43883.90	894 / 901
liver	99%	1317689.52	224 / 226	100%	30337.49	406 / 406
brain	100%	1572963.79	2634 / 2642	99%	27483.82	700 / 705
breast	100%	788643.91	459 / 459	98%	22556.03	1100 / 1118
prostate	99%	750653.91	242 / 245	100%	29492.13	500 / 502
esophagus	98%	705531.38	1421 / 1445	100%	30122.76	183 / 183
stomach	99%	874698.28	355 / 359	99%	30136.84	283 / 286
intestine	98%	925631.84	948 / 966	99%	28325.15	521 / 527
thymus	96%	613485.46	624 / 653	99%	28873.65	600 / 605
bladder	95%	566646.95	20 / 21	98%	26708.14	496 / 504
pancreas	92%	328822.66	302 / 328	99%	25316.84	177 / 178
skin	92%	568748.39	1658 / 1809	97%	26254.87	460 / 472
lung	85%	325149.41	494 / 578	95%	20140.23	1097 / 1155
uterus	82%	288751.79	140 / 170	98%	22016.73	448 / 459
ovary	66%	228694.10	119 / 180	100%	25998.13	430 / 430
eye	0%	0	0 / 0	100%	50354.86	80 / 80
muscle	100%	1117686.57	803 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	15459.81	45 / 45
ureter	0%	0	0 / 0	100%	67182.85	1 / 1
heart	100%	2215170.33	860 / 861	0%	0	0 / 0
adipose	99%	743220.80	1187 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	15794.86	28 / 29
spleen	94%	403607.90	226 / 241	0%	0	0 / 0
blood vessel	88%	331045.18	1171 / 1335	0%	0	0 / 0
peripheral blood	26%	100289.06	245 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	MT-CO3
Protein name	Cytochrome c oxidase subunit 3 (EC 7.1.1.9) (Cytochrome c oxidase polypeptide III)
Synonyms	COXIII COIII MTCO3
Description	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. .
Accessions	P00414 ENST00000362079.2

GO_1902600	Biological process	proton transmembrane transport
GO_0008535	Biological process	respiratory chain complex IV assembly
GO_0045333	Biological process	cellular respiration
GO_0006123	Biological process	mitochondrial electron transport, cytochrome c to oxygen
GO_0031966	Cellular component	mitochondrial membrane
GO_0045277	Cellular component	respiratory chain complex IV
GO_0005751	Cellular component	mitochondrial respiratory chain complex IV
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0004129	Molecular function	cytochrome-c oxidase activity
GO_0005515	Molecular function	protein binding

MT-CO3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review