MT-ATP6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0055093Biological processresponse to hyperoxia
GO_0042776Biological processproton motive force-driven mitochondrial ATP synthesis
GO_1902600Biological processproton transmembrane transport
GO_0015986Biological processproton motive force-driven ATP synthesis
GO_0005753Cellular componentmitochondrial proton-transporting ATP synthase complex
GO_0045263Cellular componentproton-transporting ATP synthase complex, coupling factor F(o)
GO_0005743Cellular componentmitochondrial inner membrane
GO_0046933Molecular functionproton-transporting ATP synthase activity, rotational mechanism
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMT-ATP6
Protein nameATP synthase subunit a (F-ATPase protein 6)
SynonymsMTATP6
ATP6
ATPASE6
DescriptionFUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.

AccessionsENST00000361899.2
P00846