MORF4L1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0042981Biological processregulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_2000779Biological processregulation of double-strand break repair
GO_0051726Biological processregulation of cell cycle
GO_1905168Biological processpositive regulation of double-strand break repair via homologous recombination
GO_0016607Cellular componentnuclear speck
GO_0070822Cellular componentSin3-type complex
GO_0005654Cellular componentnucleoplasm
GO_0000786Cellular componentnucleosome
GO_0035267Cellular componentNuA4 histone acetyltransferase complex
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMORF4L1
Protein nameMORF4L1 protein
Mortality factor 4-like protein 1 (MORF-related gene 15 protein) (MRG15) (Protein MSL3-1) (Transcription factor-like protein MRG15)
Mortality factor 4 like 1 (cDNA FLJ38504 fis, clone HCHON2000156, highly similar to Mortality factor 4-like protein 1)
Mortality factor 4 like 1
SynonymsHSPC061
MRG15
PP368
FWP006
HSPC008
DescriptionFUNCTION: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 . SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription . Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci. .

AccessionsENST00000426013.7 [Q9UBU8-2]
ENST00000558502.5 [Q9UBU8-3]
ENST00000558830.5
H0YNI8
H0YNX3
Q9UBU8
ENST00000559751.1
H0YLV1
Q0VAE4
ENST00000331268.9 [Q9UBU8-1]
H0YNE0
ENST00000379535.8
B3KTM8
H0YMT8
A5D8W6
ENST00000559244.5
ENST00000559690.5
ENST00000559158.5
ENST00000560422.5
ENST00000559345.5 [Q9UBU8-3]
ENST00000558746.5
H0YM21
H0YLJ3
ENST00000559930.5
H0YMJ0