MGST3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	44 studies	47% ± 19%	Explore
fibroblast	41 studies	48% ± 19%	Explore
pericyte	37 studies	56% ± 24%	Explore
macrophage	34 studies	44% ± 18%	Explore
smooth muscle cell	31 studies	57% ± 22%	Explore
conventional dendritic cell	25 studies	32% ± 13%	Explore
natural killer cell	24 studies	24% ± 8%	Explore
endothelial cell of lymphatic vessel	24 studies	54% ± 20%	Explore
CD8-positive, alpha-beta T cell	23 studies	25% ± 7%	Explore
epithelial cell	22 studies	51% ± 24%	Explore
classical monocyte	22 studies	34% ± 14%	Explore
non-classical monocyte	21 studies	37% ± 14%	Explore
basal cell	21 studies	43% ± 21%	Explore
CD4-positive, alpha-beta T cell	19 studies	24% ± 6%	Explore
T cell	18 studies	26% ± 13%	Explore
ciliated cell	18 studies	63% ± 22%	Explore
connective tissue cell	18 studies	48% ± 16%	Explore
regulatory T cell	18 studies	23% ± 4%	Explore
B cell	15 studies	21% ± 5%	Explore
dendritic cell	15 studies	37% ± 22%	Explore
monocyte	15 studies	29% ± 12%	Explore
mature NK T cell	14 studies	27% ± 8%	Explore
capillary endothelial cell	14 studies	47% ± 15%	Explore
myofibroblast cell	14 studies	55% ± 15%	Explore
endothelial cell of vascular tree	14 studies	42% ± 18%	Explore
myeloid cell	14 studies	41% ± 16%	Explore
gamma-delta T cell	14 studies	26% ± 7%	Explore
mast cell	13 studies	24% ± 7%	Explore
endothelial cell of artery	13 studies	45% ± 13%	Explore
astrocyte	13 studies	37% ± 19%	Explore
vein endothelial cell	12 studies	46% ± 10%	Explore
secretory cell	11 studies	47% ± 20%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	22% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	26% ± 6%	Explore
memory B cell	11 studies	19% ± 5%	Explore
type I pneumocyte	10 studies	42% ± 14%	Explore
type II pneumocyte	10 studies	47% ± 20%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	26% ± 6%	Explore
progenitor cell	10 studies	52% ± 22%	Explore
mesothelial cell	10 studies	42% ± 15%	Explore
mucosal invariant T cell	10 studies	25% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	23% ± 5%	Explore
leukocyte	9 studies	26% ± 6%	Explore
abnormal cell	9 studies	48% ± 24%	Explore
microglial cell	9 studies	28% ± 13%	Explore
adipocyte	9 studies	29% ± 8%	Explore
oligodendrocyte	9 studies	28% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	25% ± 7%	Explore
alveolar macrophage	8 studies	64% ± 28%	Explore
club cell	8 studies	38% ± 18%	Explore
plasmacytoid dendritic cell	8 studies	22% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	28% ± 8%	Explore
neuron	8 studies	50% ± 19%	Explore
enterocyte	8 studies	61% ± 20%	Explore
goblet cell	8 studies	42% ± 13%	Explore
glutamatergic neuron	8 studies	45% ± 21%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	29% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	22% ± 4%	Explore
epithelial cell of proximal tubule	7 studies	60% ± 14%	Explore
retinal ganglion cell	7 studies	68% ± 30%	Explore
plasma cell	7 studies	37% ± 11%	Explore
innate lymphoid cell	7 studies	23% ± 4%	Explore
erythrocyte	7 studies	45% ± 23%	Explore
GABAergic neuron	7 studies	43% ± 18%	Explore
oligodendrocyte precursor cell	7 studies	33% ± 10%	Explore
naive B cell	6 studies	18% ± 2%	Explore
mononuclear phagocyte	6 studies	38% ± 14%	Explore
kidney loop of Henle epithelial cell	6 studies	67% ± 10%	Explore
renal alpha-intercalated cell	6 studies	77% ± 7%	Explore
erythroblast	6 studies	39% ± 27%	Explore
transit amplifying cell	6 studies	41% ± 16%	Explore
amacrine cell	6 studies	47% ± 18%	Explore
retinal cone cell	6 studies	59% ± 22%	Explore
cardiac muscle cell	6 studies	45% ± 9%	Explore
T follicular helper cell	6 studies	20% ± 3%	Explore
ionocyte	5 studies	41% ± 12%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	69% ± 13%	Explore
retinal rod cell	5 studies	37% ± 12%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	31% ± 8%	Explore
interneuron	5 studies	44% ± 21%	Explore
hematopoietic precursor cell	4 studies	35% ± 10%	Explore
pancreatic A cell	4 studies	54% ± 12%	Explore
type B pancreatic cell	4 studies	56% ± 17%	Explore
glomerular endothelial cell	4 studies	59% ± 12%	Explore
enteroendocrine cell	4 studies	58% ± 9%	Explore
intestinal crypt stem cell	4 studies	47% ± 14%	Explore
OFF-bipolar cell	4 studies	48% ± 32%	Explore
ON-bipolar cell	4 studies	49% ± 31%	Explore
brush cell	4 studies	34% ± 19%	Explore
Schwann cell	4 studies	40% ± 16%	Explore
retina horizontal cell	4 studies	58% ± 17%	Explore
adventitial cell	4 studies	55% ± 11%	Explore
Mueller cell	4 studies	39% ± 14%	Explore
CD4-positive helper T cell	4 studies	25% ± 4%	Explore
keratinocyte	4 studies	35% ± 6%	Explore
melanocyte	4 studies	37% ± 11%	Explore
acinar cell	4 studies	37% ± 16%	Explore
muscle cell	4 studies	46% ± 21%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	30% ± 3%	Explore
intermediate monocyte	4 studies	47% ± 12%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	39% ± 5%	Explore
hepatocyte	4 studies	44% ± 27%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	31% ± 10%	Explore
deuterosomal cell	3 studies	21% ± 1%	Explore
duct epithelial cell	3 studies	46% ± 6%	Explore
respiratory goblet cell	3 studies	35% ± 23%	Explore
plasmablast	3 studies	36% ± 13%	Explore
podocyte	3 studies	38% ± 8%	Explore
neural crest cell	3 studies	43% ± 2%	Explore
retinal bipolar neuron	3 studies	50% ± 18%	Explore
GABAergic interneuron	3 studies	21% ± 4%	Explore
GABAergic amacrine cell	3 studies	35% ± 9%	Explore
glycinergic amacrine cell	3 studies	28% ± 9%	Explore
renal principal cell	3 studies	81% ± 10%	Explore
extravillous trophoblast	3 studies	90% ± 9%	Explore
placental villous trophoblast	3 studies	97% ± 3%	Explore
hematopoietic stem cell	3 studies	25% ± 6%	Explore
lymphocyte	3 studies	45% ± 10%	Explore
neuroendocrine cell	3 studies	50% ± 18%	Explore
retinal pigment epithelial cell	3 studies	48% ± 25%	Explore
mucus secreting cell	3 studies	38% ± 10%	Explore
serous secreting cell	3 studies	48% ± 19%	Explore
rod bipolar cell	3 studies	44% ± 15%	Explore
endothelial cell of sinusoid	3 studies	22% ± 5%	Explore
exhausted T cell	3 studies	28% ± 8%	Explore
myoepithelial cell	3 studies	57% ± 10%	Explore
luminal cell of prostate epithelium	3 studies	28% ± 8%	Explore
pancreatic ductal cell	3 studies	74% ± 3%	Explore
glial cell	3 studies	47% ± 14%	Explore
group 3 innate lymphoid cell	3 studies	24% ± 12%	Explore
T-helper 17 cell	3 studies	24% ± 2%	Explore
T-helper 1 cell	3 studies	27% ± 6%	Explore
double negative thymocyte	3 studies	31% ± 4%	Explore
progenitor cell of mammary luminal epithelium	3 studies	41% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	46% ± 16%	Explore
brain	16 studies	31% ± 16%	Explore
peripheral blood	14 studies	30% ± 9%	Explore
intestine	13 studies	38% ± 17%	Explore
eye	10 studies	37% ± 15%	Explore
kidney	9 studies	49% ± 12%	Explore
liver	7 studies	37% ± 24%	Explore
heart	6 studies	30% ± 9%	Explore
bone marrow	5 studies	25% ± 8%	Explore
uterus	5 studies	50% ± 20%	Explore
pancreas	4 studies	57% ± 13%	Explore
placenta	4 studies	66% ± 32%	Explore
prostate	4 studies	28% ± 7%	Explore
lymph node	4 studies	42% ± 24%	Explore
breast	4 studies	46% ± 4%	Explore
adipose	4 studies	29% ± 9%	Explore
skin	3 studies	37% ± 11%	Explore
adrenal gland	3 studies	36% ± 6%	Explore
esophagus	3 studies	45% ± 25%	Explore
thymus	3 studies	32% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	5732.11	258 / 258	100%	40.80	230 / 230
kidney	100%	6582.64	89 / 89	100%	50.49	901 / 901
ovary	100%	3925.75	180 / 180	100%	38.53	430 / 430
intestine	100%	5434.99	965 / 966	100%	38.73	527 / 527
brain	100%	5389.33	2639 / 2642	100%	33.83	705 / 705
uterus	100%	3623.89	170 / 170	100%	35.94	458 / 459
skin	100%	3454.88	1803 / 1809	100%	47.15	472 / 472
breast	100%	7090.97	459 / 459	100%	45.84	1114 / 1118
thymus	100%	5001.97	652 / 653	100%	40.87	602 / 605
lung	99%	4231.70	574 / 578	100%	31.22	1155 / 1155
prostate	100%	3073.36	244 / 245	99%	26.75	499 / 502
esophagus	100%	3902.72	1444 / 1445	99%	25.29	181 / 183
bladder	100%	3740.19	21 / 21	99%	35.87	497 / 504
liver	98%	2442.84	221 / 226	100%	31.67	406 / 406
stomach	98%	3498.99	351 / 359	100%	37.11	285 / 286
pancreas	95%	1706.53	311 / 328	99%	40.84	177 / 178
adipose	100%	7877.33	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	41.09	80 / 80
lymph node	0%	0	0 / 0	100%	15.13	29 / 29
tonsil	0%	0	0 / 0	100%	22.51	45 / 45
ureter	0%	0	0 / 0	100%	16.78	1 / 1
blood vessel	100%	6973.19	1334 / 1335	0%	0	0 / 0
muscle	100%	5747.03	800 / 803	0%	0	0 / 0
spleen	99%	2084.21	239 / 241	0%	0	0 / 0
heart	99%	10012.30	850 / 861	0%	0	0 / 0
peripheral blood	49%	917.45	452 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0019370	Biological process	leukotriene biosynthetic process
GO_0006692	Biological process	prostanoid metabolic process
GO_0006629	Biological process	lipid metabolic process
GO_0098869	Biological process	cellular oxidant detoxification
GO_0019369	Biological process	arachidonic acid metabolic process
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005635	Cellular component	nuclear envelope
GO_0016020	Cellular component	membrane
GO_0004602	Molecular function	glutathione peroxidase activity
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding
GO_0004464	Molecular function	leukotriene-C4 synthase activity
GO_0004364	Molecular function	glutathione transferase activity

IV. Literature review

[source]

Gene name	MGST3
Protein name	Glutathione S-transferase 3, mitochondrial (GST-3) (EC 2.5.1.-) (Glutathione peroxidase MGST3) (EC 1.11.1.-) (LTC4 synthase MGST3) (EC 4.4.1.20) Microsomal glutathione S-transferase 3
Synonyms
Description	FUNCTION: Displays both glutathione S-transferase and glutathione peroxidase activities toward oxyeicosanoids, as part of cellular detoxification as well as synthesis of bioactive metabolites . Catalyzes conjugate addition of reduced glutathione to the alpha, beta-unsaturated C=C carbonyl group of eisosanoids such as leukotriene A4 and 15-deoxy-Delta12,14-prostaglandin J2 to form GSH adducts relevant to the inflammatory response . Catalyzes glutathione-dependent reduction of eicosanoid peroxides to yield the corresponding eicosanoid hydroxides . .
Accessions	O14880 Q5VV87 ENST00000367888.8 Q5VV89 ENST00000367885.5 ENST00000367884.6 ENST00000627653.1 ENST00000367883.3 ENST00000367889.8

MGST3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review