KMT2E | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	49 studies	46% ± 15%	Explore
fibroblast	43 studies	37% ± 13%	Explore
natural killer cell	41 studies	45% ± 13%	Explore
B cell	40 studies	49% ± 13%	Explore
CD8-positive, alpha-beta T cell	38 studies	40% ± 13%	Explore
pericyte	36 studies	40% ± 12%	Explore
T cell	35 studies	42% ± 12%	Explore
macrophage	35 studies	36% ± 16%	Explore
smooth muscle cell	33 studies	35% ± 9%	Explore
CD4-positive, alpha-beta T cell	33 studies	42% ± 12%	Explore
regulatory T cell	28 studies	47% ± 12%	Explore
mast cell	27 studies	43% ± 16%	Explore
conventional dendritic cell	27 studies	35% ± 15%	Explore
endothelial cell of lymphatic vessel	24 studies	43% ± 15%	Explore
classical monocyte	24 studies	32% ± 12%	Explore
mature NK T cell	21 studies	43% ± 11%	Explore
non-classical monocyte	21 studies	33% ± 14%	Explore
monocyte	20 studies	36% ± 13%	Explore
memory B cell	20 studies	53% ± 11%	Explore
naive B cell	20 studies	49% ± 11%	Explore
astrocyte	20 studies	42% ± 17%	Explore
gamma-delta T cell	19 studies	48% ± 15%	Explore
plasmacytoid dendritic cell	19 studies	38% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	41% ± 11%	Explore
basal cell	18 studies	39% ± 15%	Explore
epithelial cell	18 studies	41% ± 20%	Explore
dendritic cell	17 studies	43% ± 18%	Explore
microglial cell	17 studies	50% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	49% ± 14%	Explore
mucosal invariant T cell	16 studies	50% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	52% ± 11%	Explore
oligodendrocyte precursor cell	16 studies	51% ± 18%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	41% ± 13%	Explore
plasma cell	15 studies	34% ± 12%	Explore
ciliated cell	15 studies	33% ± 10%	Explore
oligodendrocyte	15 studies	52% ± 17%	Explore
capillary endothelial cell	15 studies	36% ± 9%	Explore
myofibroblast cell	15 studies	40% ± 12%	Explore
connective tissue cell	15 studies	38% ± 11%	Explore
endothelial cell of vascular tree	14 studies	45% ± 15%	Explore
myeloid cell	14 studies	38% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	50% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	45% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	51% ± 13%	Explore
endothelial cell of artery	13 studies	43% ± 10%	Explore
vein endothelial cell	13 studies	43% ± 16%	Explore
glutamatergic neuron	12 studies	58% ± 22%	Explore
type II pneumocyte	11 studies	36% ± 14%	Explore
club cell	11 studies	35% ± 12%	Explore
leukocyte	11 studies	45% ± 16%	Explore
GABAergic neuron	11 studies	56% ± 22%	Explore
type I pneumocyte	10 studies	44% ± 7%	Explore
neuron	10 studies	58% ± 18%	Explore
secretory cell	9 studies	30% ± 11%	Explore
abnormal cell	9 studies	39% ± 14%	Explore
mesothelial cell	9 studies	37% ± 10%	Explore
adipocyte	9 studies	32% ± 10%	Explore
innate lymphoid cell	8 studies	45% ± 13%	Explore
plasmablast	8 studies	47% ± 24%	Explore
respiratory goblet cell	8 studies	37% ± 15%	Explore
progenitor cell	8 studies	38% ± 13%	Explore
goblet cell	8 studies	34% ± 24%	Explore
T follicular helper cell	8 studies	47% ± 8%	Explore
amacrine cell	8 studies	57% ± 14%	Explore
retinal rod cell	8 studies	49% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	38% ± 8%	Explore
mononuclear phagocyte	7 studies	37% ± 12%	Explore
retinal ganglion cell	7 studies	55% ± 18%	Explore
precursor B cell	7 studies	56% ± 12%	Explore
retinal cone cell	7 studies	62% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	42% ± 10%	Explore
ionocyte	6 studies	32% ± 11%	Explore
neutrophil	6 studies	27% ± 12%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	40% ± 8%	Explore
glial cell	6 studies	41% ± 14%	Explore
interneuron	6 studies	72% ± 14%	Explore
hematopoietic stem cell	6 studies	44% ± 9%	Explore
lymphocyte	6 studies	52% ± 19%	Explore
immature B cell	6 studies	55% ± 4%	Explore
retina horizontal cell	6 studies	58% ± 9%	Explore
Mueller cell	6 studies	47% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	51% ± 15%	Explore
CD4-positive helper T cell	5 studies	42% ± 18%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	41% ± 11%	Explore
hematopoietic precursor cell	5 studies	49% ± 22%	Explore
exhausted T cell	5 studies	47% ± 11%	Explore
platelet	5 studies	19% ± 2%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	26% ± 7%	Explore
enteroendocrine cell	5 studies	32% ± 11%	Explore
retinal bipolar neuron	5 studies	60% ± 10%	Explore
OFF-bipolar cell	5 studies	50% ± 15%	Explore
ON-bipolar cell	5 studies	50% ± 17%	Explore
kidney loop of Henle epithelial cell	5 studies	21% ± 6%	Explore
pro-B cell	5 studies	55% ± 8%	Explore
brush cell	5 studies	35% ± 7%	Explore
cardiac muscle cell	5 studies	38% ± 6%	Explore
erythrocyte	5 studies	36% ± 15%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	28% ± 8%	Explore
duct epithelial cell	4 studies	33% ± 19%	Explore
squamous epithelial cell	4 studies	42% ± 18%	Explore
glomerular endothelial cell	4 studies	33% ± 10%	Explore
renal alpha-intercalated cell	4 studies	30% ± 10%	Explore
differentiation-committed oligodendrocyte precursor	4 studies	53% ± 7%	Explore
IgA plasma cell	4 studies	28% ± 11%	Explore
IgG plasma cell	4 studies	25% ± 6%	Explore
granule cell	4 studies	51% ± 5%	Explore
GABAergic amacrine cell	4 studies	51% ± 21%	Explore
glycinergic amacrine cell	4 studies	52% ± 15%	Explore
retinal pigment epithelial cell	4 studies	48% ± 21%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	29% ± 4%	Explore
hepatocyte	4 studies	40% ± 11%	Explore
granulocyte	4 studies	48% ± 11%	Explore
muscle cell	4 studies	45% ± 23%	Explore
alveolar macrophage	4 studies	42% ± 15%	Explore
mucus secreting cell	4 studies	38% ± 10%	Explore
group 3 innate lymphoid cell	4 studies	65% ± 8%	Explore
melanocyte	4 studies	48% ± 19%	Explore
T-helper 17 cell	4 studies	43% ± 15%	Explore
T-helper 1 cell	4 studies	50% ± 8%	Explore
double negative thymocyte	4 studies	57% ± 14%	Explore
renal principal cell	4 studies	26% ± 6%	Explore
precursor cell	3 studies	42% ± 15%	Explore
podocyte	3 studies	39% ± 2%	Explore
epithelial cell of proximal tubule	3 studies	21% ± 4%	Explore
intestinal crypt stem cell	3 studies	19% ± 4%	Explore
neural crest cell	3 studies	36% ± 6%	Explore
GABAergic interneuron	3 studies	56% ± 4%	Explore
serous secreting cell	3 studies	23% ± 4%	Explore
tissue-resident macrophage	3 studies	43% ± 10%	Explore
intraepithelial lymphocyte	3 studies	38% ± 19%	Explore
rod bipolar cell	3 studies	71% ± 7%	Explore
germinal center B cell	3 studies	38% ± 7%	Explore
intermediate monocyte	3 studies	53% ± 22%	Explore
ependymal cell	3 studies	51% ± 14%	Explore
adventitial cell	3 studies	35% ± 2%	Explore
chondrocyte	3 studies	42% ± 8%	Explore
Schwann cell	3 studies	47% ± 18%	Explore
keratinocyte	3 studies	28% ± 7%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	46% ± 5%	Explore
double-positive, alpha-beta thymocyte	3 studies	63% ± 11%	Explore
myoepithelial cell	3 studies	47% ± 11%	Explore
mural cell	3 studies	64% ± 11%	Explore
luminal cell of prostate epithelium	3 studies	33% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	20 studies	37% ± 10%	Explore
brain	20 studies	51% ± 21%	Explore
peripheral blood	18 studies	44% ± 14%	Explore
eye	11 studies	50% ± 16%	Explore
intestine	10 studies	31% ± 12%	Explore
kidney	9 studies	30% ± 9%	Explore
heart	5 studies	37% ± 7%	Explore
lymph node	5 studies	39% ± 11%	Explore
breast	5 studies	32% ± 5%	Explore
liver	5 studies	44% ± 11%	Explore
bone marrow	4 studies	41% ± 14%	Explore
uterus	4 studies	36% ± 7%	Explore
adipose	4 studies	38% ± 8%	Explore
prostate	3 studies	28% ± 9%	Explore
skin	3 studies	34% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5687.06	1445 / 1445	100%	44.86	183 / 183
lung	100%	7586.00	578 / 578	100%	28.89	1154 / 1155
ovary	100%	8383.58	180 / 180	100%	29.53	429 / 430
brain	100%	4826.22	2635 / 2642	100%	37.15	705 / 705
intestine	100%	6935.37	966 / 966	100%	28.58	525 / 527
breast	100%	7614.74	459 / 459	99%	34.97	1112 / 1118
prostate	100%	6452.56	245 / 245	99%	28.83	499 / 502
thymus	100%	7087.51	653 / 653	99%	30.37	601 / 605
stomach	100%	4603.83	359 / 359	99%	32.78	284 / 286
bladder	100%	6377.19	21 / 21	99%	22.24	500 / 504
pancreas	100%	3126.96	328 / 328	99%	25.70	176 / 178
uterus	100%	8198.89	170 / 170	98%	21.83	449 / 459
skin	100%	7533.95	1809 / 1809	97%	34.55	460 / 472
kidney	100%	3617.97	89 / 89	97%	27.43	876 / 901
adrenal gland	100%	4078.31	258 / 258	95%	16.31	218 / 230
liver	99%	1904.85	223 / 226	75%	9.43	306 / 406
adipose	100%	7531.88	1204 / 1204	0%	0	0 / 0
blood vessel	100%	7822.36	1335 / 1335	0%	0	0 / 0
spleen	100%	5884.80	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	7.56	1 / 1
muscle	100%	3247.95	801 / 803	0%	0	0 / 0
heart	99%	3470.18	852 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	22.16	43 / 45
peripheral blood	95%	4819.67	884 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	20.90	27 / 29
eye	0%	0	0 / 0	89%	15.69	71 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1900087	Biological process	positive regulation of G1/S transition of mitotic cell cycle
GO_0030218	Biological process	erythrocyte differentiation
GO_0002446	Biological process	neutrophil mediated immunity
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0040029	Biological process	epigenetic regulation of gene expression
GO_0042119	Biological process	neutrophil activation
GO_0005886	Cellular component	plasma membrane
GO_0034967	Cellular component	Set3 complex
GO_0016607	Cellular component	nuclear speck
GO_0005813	Cellular component	centrosome
GO_0000791	Cellular component	euchromatin
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0016604	Cellular component	nuclear body
GO_0005737	Cellular component	cytoplasm
GO_0070210	Cellular component	Rpd3L-Expanded complex
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0035064	Molecular function	methylated histone binding
GO_0019899	Molecular function	enzyme binding
GO_0046872	Molecular function	metal ion binding
GO_0140938	Molecular function	histone H3 methyltransferase activity
GO_0003713	Molecular function	transcription coactivator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	KMT2E
Protein name	Inactive histone-lysine N-methyltransferase 2E Lysine methyltransferase 2E (inactive) Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5)
Synonyms	MLL5
Description	FUNCTION: Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription . Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) . Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry . Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition . During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). .; FUNCTION: [Isoform NKp44L]: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. .
Accessions	A0A087WYW5 ENST00000478079.1 A0A590UK87 ENST00000700336.1 ENST00000478990.6 S4R363 ENST00000257745.9 ENST00000474203.6 [Q8IZD2-3] ENST00000474203.5 ENST00000622386.2 ENST00000476671.5 [Q8IZD2-3] ENST00000478079.2 [Q8IZD2-8] A0A8V8TR58 H7C5C4 ENST00000667857.1 ENST00000482560.6 C9JYI9 ENST00000311117.8 [Q8IZD2-1] A0A8J9FJW2 ENST00000473063.1 Q8IZD2 C9JQ68 ENST00000334884.9 [Q8IZD2-4] ENST00000473063.2 [Q8IZD2-7] ENST00000479838.3 ENST00000495267.5 F8WAU9 C9JNE1 H7C4F3

KMT2E report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review