Name | Number of supported studies | Average coverage | |
---|---|---|---|
lung | 18 studies | 35% ± 12% | |
peripheral blood | 16 studies | 29% ± 11% | |
brain | 15 studies | 30% ± 14% | |
intestine | 9 studies | 30% ± 13% | |
eye | 9 studies | 31% ± 12% | |
kidney | 7 studies | 27% ± 7% | |
lymph node | 5 studies | 28% ± 10% | |
pancreas | 4 studies | 57% ± 23% | |
placenta | 4 studies | 28% ± 10% | |
bone marrow | 4 studies | 30% ± 10% | |
heart | 4 studies | 19% ± 3% | |
uterus | 4 studies | 40% ± 13% | |
breast | 4 studies | 32% ± 5% | |
prostate | 4 studies | 24% ± 8% | |
liver | 4 studies | 34% ± 11% | |
adipose | 4 studies | 23% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 9536.58 | 459 / 459 | 100% | 163.59 | 1118 / 1118 |
esophagus | 100% | 13392.85 | 1445 / 1445 | 100% | 173.05 | 183 / 183 |
brain | 100% | 15710.90 | 2641 / 2642 | 100% | 120.57 | 705 / 705 |
lung | 100% | 11072.98 | 577 / 578 | 100% | 118.56 | 1155 / 1155 |
intestine | 100% | 15072.49 | 966 / 966 | 100% | 163.02 | 526 / 527 |
ovary | 100% | 6868.23 | 180 / 180 | 100% | 69.17 | 429 / 430 |
stomach | 100% | 8082.39 | 359 / 359 | 100% | 170.74 | 285 / 286 |
bladder | 100% | 13670.48 | 21 / 21 | 100% | 116.82 | 502 / 504 |
prostate | 100% | 10591.67 | 244 / 245 | 100% | 143.09 | 502 / 502 |
thymus | 100% | 8130.37 | 652 / 653 | 100% | 92.68 | 603 / 605 |
uterus | 100% | 11879.54 | 170 / 170 | 99% | 100.00 | 455 / 459 |
adrenal gland | 100% | 7959.90 | 258 / 258 | 98% | 92.35 | 225 / 230 |
kidney | 100% | 5760.03 | 89 / 89 | 97% | 74.18 | 871 / 901 |
pancreas | 96% | 4428.34 | 314 / 328 | 99% | 111.94 | 177 / 178 |
skin | 100% | 10753.79 | 1804 / 1809 | 91% | 90.10 | 430 / 472 |
liver | 77% | 2473.66 | 173 / 226 | 80% | 41.12 | 326 / 406 |
adipose | 100% | 10139.33 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 16839.41 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 61.42 | 29 / 29 |
muscle | 100% | 10912.69 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 6614.44 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 94.47 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 46.23 | 1 / 1 |
heart | 98% | 8996.30 | 843 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 61% | 34.61 | 49 / 80 |
peripheral blood | 59% | 3593.78 | 552 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0042391 | Biological process | regulation of membrane potential |
GO_0072383 | Biological process | plus-end-directed vesicle transport along microtubule |
GO_0007028 | Biological process | cytoplasm organization |
GO_0047497 | Biological process | mitochondrion transport along microtubule |
GO_0051642 | Biological process | centrosome localization |
GO_0160040 | Biological process | mitocytosis |
GO_1990049 | Biological process | retrograde neuronal dense core vesicle transport |
GO_0042267 | Biological process | natural killer cell mediated cytotoxicity |
GO_1903078 | Biological process | positive regulation of protein localization to plasma membrane |
GO_0035617 | Biological process | stress granule disassembly |
GO_0007018 | Biological process | microtubule-based movement |
GO_0032418 | Biological process | lysosome localization |
GO_0043268 | Biological process | positive regulation of potassium ion transport |
GO_0098971 | Biological process | anterograde dendritic transport of neurotransmitter receptor complex |
GO_0032230 | Biological process | positive regulation of synaptic transmission, GABAergic |
GO_1990048 | Biological process | anterograde neuronal dense core vesicle transport |
GO_0047496 | Biological process | vesicle transport along microtubule |
GO_0007411 | Biological process | axon guidance |
GO_0099641 | Biological process | anterograde axonal protein transport |
GO_0071346 | Biological process | cellular response to type II interferon |
GO_0048489 | Biological process | synaptic vesicle transport |
GO_0034451 | Cellular component | centriolar satellite |
GO_0005874 | Cellular component | microtubule |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0016020 | Cellular component | membrane |
GO_0005739 | Cellular component | mitochondrion |
GO_0005871 | Cellular component | kinesin complex |
GO_0035253 | Cellular component | ciliary rootlet |
GO_0005829 | Cellular component | cytosol |
GO_0045335 | Cellular component | phagocytic vesicle |
GO_0032839 | Cellular component | dendrite cytoplasm |
GO_0101004 | Cellular component | cytolytic granule membrane |
GO_0031982 | Cellular component | vesicle |
GO_1904115 | Cellular component | axon cytoplasm |
GO_0008574 | Molecular function | plus-end-directed microtubule motor activity |
GO_0044877 | Molecular function | protein-containing complex binding |
GO_0045296 | Molecular function | cadherin binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0016887 | Molecular function | ATP hydrolysis activity |
GO_0003777 | Molecular function | microtubule motor activity |
GO_0008017 | Molecular function | microtubule binding |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
Gene name | KIF5B |
Protein name | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) Kinesin-like protein |
Synonyms | KNS1 KNS |
Description | FUNCTION: Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes . Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells . . |
Accessions | ENST00000302418.5 Q2TA90 Q66K46 Q6P164 P33176 |