ITM2B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007399Biological processnervous system development
GO_0042985Biological processnegative regulation of amyloid precursor protein biosynthetic process
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005615Cellular componentextracellular space
GO_0010008Cellular componentendosome membrane
GO_0030660Cellular componentGolgi-associated vesicle membrane
GO_0000139Cellular componentGolgi membrane
GO_0031090Cellular componentorganelle membrane
GO_0070062Cellular componentextracellular exosome
GO_0005576Cellular componentextracellular region
GO_0005794Cellular componentGolgi apparatus
GO_0016020Cellular componentmembrane
GO_0005886Cellular componentplasma membrane
GO_0001540Molecular functionamyloid-beta binding
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameITM2B
Protein nameIntegral membrane protein 2
Integral membrane protein 2B (Immature BRI2) (imBRI2) (Protein E25B) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]
Integral membrane protein 2B
SynonymsBRI
BRI2
DescriptionFUNCTION: Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites.; FUNCTION: Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42.; FUNCTION: Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers.

FUNCTION: Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers. .; FUNCTION: Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42. .; FUNCTION: Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites. .

AccessionsENST00000607866.1
A0A3B3IUC0
ENST00000649266.1
U3KQL7
A0A3B3ISG3
ENST00000647800.2 [Q9Y287-1]
U3KQ52
ENST00000463839.3
ENST00000378549.5 [Q9Y287-2]
ENST00000649452.1
ENST00000650237.1
ENST00000650479.1
A0A3B3ITP9
Q9Y287
A0A3B3IU60