IER2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	44 studies	60% ± 18%	Explore
endothelial cell	43 studies	52% ± 25%	Explore
B cell	41 studies	48% ± 17%	Explore
fibroblast	38 studies	54% ± 22%	Explore
CD8-positive, alpha-beta T cell	38 studies	47% ± 14%	Explore
macrophage	37 studies	45% ± 18%	Explore
T cell	34 studies	46% ± 18%	Explore
pericyte	32 studies	58% ± 24%	Explore
conventional dendritic cell	32 studies	59% ± 16%	Explore
CD4-positive, alpha-beta T cell	32 studies	47% ± 18%	Explore
regulatory T cell	29 studies	46% ± 20%	Explore
smooth muscle cell	26 studies	57% ± 23%	Explore
classical monocyte	26 studies	63% ± 20%	Explore
mast cell	25 studies	57% ± 22%	Explore
dendritic cell	24 studies	51% ± 22%	Explore
monocyte	23 studies	52% ± 19%	Explore
endothelial cell of lymphatic vessel	23 studies	50% ± 18%	Explore
non-classical monocyte	23 studies	58% ± 16%	Explore
epithelial cell	23 studies	59% ± 23%	Explore
basal cell	22 studies	58% ± 20%	Explore
mature NK T cell	21 studies	53% ± 17%	Explore
memory B cell	20 studies	51% ± 13%	Explore
naive B cell	20 studies	41% ± 13%	Explore
plasmacytoid dendritic cell	20 studies	33% ± 12%	Explore
plasma cell	18 studies	46% ± 17%	Explore
gamma-delta T cell	18 studies	57% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	35% ± 12%	Explore
ciliated cell	17 studies	52% ± 25%	Explore
CD16-negative, CD56-bright natural killer cell, human	17 studies	67% ± 21%	Explore
connective tissue cell	17 studies	60% ± 19%	Explore
mucosal invariant T cell	16 studies	55% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	64% ± 17%	Explore
endothelial cell of artery	16 studies	52% ± 21%	Explore
capillary endothelial cell	16 studies	49% ± 18%	Explore
endothelial cell of vascular tree	15 studies	54% ± 18%	Explore
myeloid cell	14 studies	51% ± 25%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	45% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	59% ± 18%	Explore
neutrophil	13 studies	56% ± 15%	Explore
myofibroblast cell	13 studies	62% ± 18%	Explore
vein endothelial cell	13 studies	54% ± 15%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	55% ± 17%	Explore
secretory cell	12 studies	56% ± 20%	Explore
goblet cell	12 studies	53% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	54% ± 11%	Explore
innate lymphoid cell	11 studies	62% ± 14%	Explore
plasmablast	11 studies	47% ± 17%	Explore
mesothelial cell	11 studies	57% ± 25%	Explore
type II pneumocyte	10 studies	52% ± 21%	Explore
club cell	9 studies	50% ± 23%	Explore
leukocyte	9 studies	50% ± 16%	Explore
abnormal cell	9 studies	51% ± 18%	Explore
type I pneumocyte	8 studies	49% ± 23%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	55% ± 20%	Explore
progenitor cell	8 studies	60% ± 18%	Explore
IgA plasma cell	8 studies	33% ± 10%	Explore
IgG plasma cell	8 studies	31% ± 12%	Explore
CD4-positive helper T cell	7 studies	48% ± 23%	Explore
respiratory goblet cell	7 studies	38% ± 17%	Explore
enterocyte	7 studies	41% ± 15%	Explore
enteroendocrine cell	7 studies	55% ± 26%	Explore
precursor B cell	7 studies	51% ± 13%	Explore
T follicular helper cell	7 studies	45% ± 24%	Explore
hematopoietic precursor cell	6 studies	54% ± 19%	Explore
ionocyte	6 studies	36% ± 22%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	61% ± 20%	Explore
transit amplifying cell	6 studies	46% ± 23%	Explore
keratinocyte	6 studies	43% ± 19%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	57% ± 18%	Explore
alveolar macrophage	5 studies	29% ± 9%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	46% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	47% ± 6%	Explore
duct epithelial cell	5 studies	41% ± 16%	Explore
exhausted T cell	5 studies	52% ± 17%	Explore
platelet	5 studies	34% ± 14%	Explore
mononuclear phagocyte	5 studies	56% ± 14%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	53% ± 17%	Explore
kidney loop of Henle epithelial cell	5 studies	35% ± 15%	Explore
renal alpha-intercalated cell	5 studies	50% ± 18%	Explore
hematopoietic stem cell	5 studies	42% ± 17%	Explore
pro-B cell	5 studies	45% ± 14%	Explore
brush cell	5 studies	45% ± 22%	Explore
T-helper 17 cell	5 studies	61% ± 20%	Explore
group 3 innate lymphoid cell	5 studies	78% ± 13%	Explore
immature B cell	5 studies	62% ± 14%	Explore
intermediate monocyte	5 studies	69% ± 10%	Explore
granulocyte	5 studies	56% ± 19%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	44% ± 23%	Explore
squamous epithelial cell	4 studies	51% ± 24%	Explore
monocyte-derived dendritic cell	4 studies	57% ± 25%	Explore
erythrocyte	4 studies	42% ± 16%	Explore
glomerular endothelial cell	4 studies	47% ± 18%	Explore
epithelial cell of proximal tubule	4 studies	28% ± 19%	Explore
intestinal crypt stem cell	4 studies	61% ± 14%	Explore
astrocyte	4 studies	58% ± 18%	Explore
microglial cell	4 studies	49% ± 27%	Explore
Schwann cell	4 studies	62% ± 17%	Explore
adventitial cell	4 studies	62% ± 12%	Explore
melanocyte	4 studies	41% ± 21%	Explore
acinar cell	4 studies	36% ± 20%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	74% ± 8%	Explore
inflammatory macrophage	4 studies	27% ± 8%	Explore
glial cell	4 studies	53% ± 12%	Explore
mucus secreting cell	4 studies	30% ± 14%	Explore
double negative thymocyte	4 studies	51% ± 18%	Explore
deuterosomal cell	3 studies	27% ± 1%	Explore
precursor cell	3 studies	60% ± 11%	Explore
pancreatic A cell	3 studies	27% ± 10%	Explore
pancreatic D cell	3 studies	52% ± 24%	Explore
kidney connecting tubule epithelial cell	3 studies	66% ± 20%	Explore
podocyte	3 studies	64% ± 11%	Explore
interstitial cell of Cajal	3 studies	56% ± 12%	Explore
renal principal cell	3 studies	58% ± 14%	Explore
extravillous trophoblast	3 studies	62% ± 12%	Explore
placental villous trophoblast	3 studies	68% ± 5%	Explore
lymphocyte	3 studies	60% ± 22%	Explore
neuron	3 studies	52% ± 19%	Explore
retinal pigment epithelial cell	3 studies	58% ± 11%	Explore
intraepithelial lymphocyte	3 studies	50% ± 9%	Explore
germinal center B cell	3 studies	31% ± 4%	Explore
myoepithelial cell	3 studies	60% ± 22%	Explore
luminal cell of prostate epithelium	3 studies	38% ± 12%	Explore
pancreatic ductal cell	3 studies	71% ± 7%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	76% ± 15%	Explore
T-helper 1 cell	3 studies	72% ± 7%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	43% ± 17%	Explore
double-positive, alpha-beta thymocyte	3 studies	57% ± 16%	Explore
progenitor cell of mammary luminal epithelium	3 studies	75% ± 11%	Explore
IgM plasma cell	3 studies	30% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	51% ± 18%	Explore
peripheral blood	18 studies	52% ± 11%	Explore
intestine	15 studies	45% ± 24%	Explore
kidney	9 studies	40% ± 17%	Explore
eye	7 studies	33% ± 17%	Explore
lymph node	6 studies	51% ± 16%	Explore
pancreas	5 studies	30% ± 9%	Explore
placenta	5 studies	48% ± 23%	Explore
uterus	5 studies	71% ± 19%	Explore
skin	5 studies	50% ± 17%	Explore
liver	5 studies	39% ± 12%	Explore
bone marrow	4 studies	48% ± 18%	Explore
prostate	4 studies	44% ± 9%	Explore
breast	4 studies	66% ± 13%	Explore
ovary	3 studies	43% ± 9%	Explore
adrenal gland	3 studies	43% ± 16%	Explore
esophagus	3 studies	58% ± 20%	Explore
brain	3 studies	27% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	4496.35	245 / 245	100%	134.64	500 / 502
thymus	100%	6311.05	653 / 653	99%	121.52	601 / 605
bladder	100%	5061.71	21 / 21	99%	83.60	500 / 504
uterus	100%	3991.74	170 / 170	99%	114.76	455 / 459
skin	100%	8043.07	1808 / 1809	99%	56.84	468 / 472
intestine	100%	5205.65	964 / 966	98%	74.07	517 / 527
breast	100%	5420.42	459 / 459	98%	82.85	1093 / 1118
esophagus	100%	4759.23	1443 / 1445	98%	44.89	179 / 183
stomach	100%	5324.20	359 / 359	97%	61.70	278 / 286
lung	100%	7116.26	577 / 578	97%	53.77	1123 / 1155
ovary	100%	5599.00	180 / 180	95%	53.08	410 / 430
kidney	100%	4468.67	89 / 89	93%	56.74	839 / 901
adrenal gland	100%	3764.36	258 / 258	92%	78.12	212 / 230
pancreas	91%	3056.90	300 / 328	98%	87.97	175 / 178
liver	98%	3084.61	221 / 226	89%	37.91	361 / 406
brain	82%	1640.55	2178 / 2642	89%	38.08	627 / 705
lymph node	0%	0	0 / 0	100%	81.70	29 / 29
spleen	100%	5486.51	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	98.27	45 / 45
ureter	0%	0	0 / 0	100%	82.51	1 / 1
peripheral blood	99%	6695.40	922 / 929	0%	0	0 / 0
adipose	99%	6213.47	1193 / 1204	0%	0	0 / 0
blood vessel	99%	5159.02	1322 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	96%	34.62	77 / 80
heart	92%	2751.22	792 / 861	0%	0	0 / 0
muscle	28%	434.52	222 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0048870	Biological process	cell motility
GO_0030182	Biological process	neuron differentiation
GO_0071774	Biological process	response to fibroblast growth factor
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0005515	Molecular function	protein binding

Gene name	IER2
Protein name	Immediate early response gene 2 protein (Protein ETR101)
Synonyms	PIP92 ETR101
Description	FUNCTION: DNA-binding protein that seems to act as a transcription factor . Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis . .
Accessions	ENST00000587885.1 ENST00000588173.1 Q9BTL4 ENST00000292433.4

IER2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review