H2AZ1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	39 studies	44% ± 16%	Explore
natural killer cell	37 studies	51% ± 15%	Explore
endothelial cell	36 studies	56% ± 22%	Explore
fibroblast	35 studies	51% ± 17%	Explore
macrophage	34 studies	49% ± 15%	Explore
CD8-positive, alpha-beta T cell	34 studies	49% ± 20%	Explore
T cell	32 studies	53% ± 21%	Explore
CD4-positive, alpha-beta T cell	31 studies	50% ± 20%	Explore
pericyte	30 studies	55% ± 19%	Explore
conventional dendritic cell	29 studies	57% ± 14%	Explore
smooth muscle cell	26 studies	59% ± 17%	Explore
regulatory T cell	26 studies	51% ± 16%	Explore
classical monocyte	25 studies	48% ± 13%	Explore
non-classical monocyte	24 studies	63% ± 15%	Explore
dendritic cell	23 studies	57% ± 21%	Explore
plasma cell	23 studies	49% ± 20%	Explore
plasmacytoid dendritic cell	22 studies	45% ± 13%	Explore
mast cell	21 studies	43% ± 15%	Explore
monocyte	21 studies	45% ± 17%	Explore
basal cell	21 studies	57% ± 16%	Explore
epithelial cell	21 studies	56% ± 18%	Explore
endothelial cell of lymphatic vessel	19 studies	57% ± 13%	Explore
memory B cell	19 studies	40% ± 15%	Explore
mature NK T cell	18 studies	42% ± 13%	Explore
connective tissue cell	18 studies	57% ± 15%	Explore
naive B cell	17 studies	35% ± 11%	Explore
gamma-delta T cell	17 studies	51% ± 15%	Explore
ciliated cell	16 studies	48% ± 18%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	40% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	43% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	41% ± 15%	Explore
capillary endothelial cell	13 studies	48% ± 20%	Explore
myofibroblast cell	13 studies	59% ± 15%	Explore
myeloid cell	13 studies	59% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	53% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	51% ± 16%	Explore
secretory cell	12 studies	51% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	41% ± 11%	Explore
endothelial cell of artery	12 studies	55% ± 18%	Explore
mucosal invariant T cell	12 studies	37% ± 9%	Explore
plasmablast	11 studies	58% ± 25%	Explore
vein endothelial cell	11 studies	55% ± 17%	Explore
endothelial cell of vascular tree	11 studies	68% ± 14%	Explore
neutrophil	10 studies	41% ± 19%	Explore
abnormal cell	10 studies	53% ± 18%	Explore
type II pneumocyte	9 studies	41% ± 21%	Explore
effector CD8-positive, alpha-beta T cell	9 studies	59% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	46% ± 14%	Explore
progenitor cell	9 studies	72% ± 12%	Explore
innate lymphoid cell	9 studies	54% ± 12%	Explore
goblet cell	9 studies	44% ± 13%	Explore
type I pneumocyte	8 studies	33% ± 16%	Explore
platelet	8 studies	24% ± 6%	Explore
leukocyte	8 studies	57% ± 13%	Explore
neuron	8 studies	55% ± 24%	Explore
mesothelial cell	8 studies	49% ± 18%	Explore
T follicular helper cell	8 studies	56% ± 18%	Explore
club cell	7 studies	54% ± 11%	Explore
epithelial cell of proximal tubule	7 studies	40% ± 12%	Explore
precursor B cell	7 studies	58% ± 20%	Explore
alveolar macrophage	6 studies	57% ± 23%	Explore
hematopoietic precursor cell	6 studies	62% ± 25%	Explore
ionocyte	6 studies	55% ± 19%	Explore
respiratory goblet cell	6 studies	51% ± 18%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	65% ± 14%	Explore
kidney loop of Henle epithelial cell	6 studies	38% ± 2%	Explore
renal alpha-intercalated cell	6 studies	57% ± 12%	Explore
enterocyte	6 studies	32% ± 9%	Explore
erythroblast	6 studies	64% ± 32%	Explore
IgG plasma cell	6 studies	29% ± 10%	Explore
transit amplifying cell	6 studies	61% ± 28%	Explore
retinal rod cell	6 studies	47% ± 22%	Explore
astrocyte	6 studies	34% ± 13%	Explore
hematopoietic stem cell	6 studies	58% ± 20%	Explore
brush cell	6 studies	47% ± 26%	Explore
erythrocyte	6 studies	56% ± 26%	Explore
CD4-positive helper T cell	5 studies	42% ± 17%	Explore
CD4-positive, alpha-beta cytotoxic T cell	5 studies	52% ± 21%	Explore
exhausted T cell	5 studies	49% ± 17%	Explore
mononuclear phagocyte	5 studies	59% ± 14%	Explore
intestinal crypt stem cell	5 studies	45% ± 21%	Explore
IgA plasma cell	5 studies	29% ± 12%	Explore
retinal ganglion cell	5 studies	65% ± 29%	Explore
retinal cone cell	5 studies	61% ± 30%	Explore
pro-B cell	5 studies	64% ± 16%	Explore
intermediate monocyte	5 studies	64% ± 16%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	59% ± 20%	Explore
granulocyte	5 studies	48% ± 13%	Explore
glutamatergic neuron	5 studies	35% ± 13%	Explore
deuterosomal cell	4 studies	75% ± 23%	Explore
monocyte-derived dendritic cell	4 studies	65% ± 10%	Explore
glomerular endothelial cell	4 studies	37% ± 13%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	61% ± 23%	Explore
enteroendocrine cell	4 studies	63% ± 14%	Explore
OFF-bipolar cell	4 studies	51% ± 27%	Explore
ON-bipolar cell	4 studies	49% ± 28%	Explore
megakaryocyte	4 studies	47% ± 12%	Explore
immature B cell	4 studies	46% ± 20%	Explore
amacrine cell	4 studies	53% ± 21%	Explore
retina horizontal cell	4 studies	41% ± 19%	Explore
microglial cell	4 studies	50% ± 18%	Explore
adventitial cell	4 studies	30% ± 10%	Explore
germinal center B cell	4 studies	62% ± 12%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	68% ± 7%	Explore
GABAergic neuron	4 studies	28% ± 9%	Explore
oligodendrocyte precursor cell	4 studies	45% ± 23%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	73% ± 28%	Explore
glial cell	4 studies	40% ± 21%	Explore
group 3 innate lymphoid cell	4 studies	53% ± 16%	Explore
T-helper 17 cell	4 studies	61% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	44% ± 5%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	46% ± 10%	Explore
duct epithelial cell	3 studies	52% ± 10%	Explore
precursor cell	3 studies	79% ± 14%	Explore
squamous epithelial cell	3 studies	50% ± 23%	Explore
pancreatic A cell	3 studies	68% ± 18%	Explore
type B pancreatic cell	3 studies	70% ± 16%	Explore
neural crest cell	3 studies	83% ± 21%	Explore
retinal bipolar neuron	3 studies	66% ± 25%	Explore
GABAergic amacrine cell	3 studies	32% ± 12%	Explore
glycinergic amacrine cell	3 studies	26% ± 10%	Explore
renal principal cell	3 studies	47% ± 8%	Explore
thymocyte	3 studies	57% ± 31%	Explore
extravillous trophoblast	3 studies	77% ± 11%	Explore
placental villous trophoblast	3 studies	72% ± 14%	Explore
common myeloid progenitor	3 studies	57% ± 29%	Explore
lymphocyte	3 studies	74% ± 15%	Explore
neuroendocrine cell	3 studies	58% ± 21%	Explore
retinal pigment epithelial cell	3 studies	52% ± 25%	Explore
mucus secreting cell	3 studies	35% ± 8%	Explore
serous secreting cell	3 studies	40% ± 8%	Explore
Mueller cell	3 studies	45% ± 12%	Explore
rod bipolar cell	3 studies	52% ± 20%	Explore
acinar cell	3 studies	32% ± 10%	Explore
muscle cell	3 studies	57% ± 16%	Explore
myoepithelial cell	3 studies	67% ± 11%	Explore
inflammatory macrophage	3 studies	30% ± 10%	Explore
luminal cell of prostate epithelium	3 studies	53% ± 9%	Explore
granulocyte monocyte progenitor cell	3 studies	66% ± 34%	Explore
hepatocyte	3 studies	34% ± 23%	Explore
keratinocyte	3 studies	73% ± 15%	Explore
melanocyte	3 studies	70% ± 22%	Explore
interneuron	3 studies	28% ± 2%	Explore
oligodendrocyte	3 studies	21% ± 3%	Explore
double negative thymocyte	3 studies	60% ± 22%	Explore
progenitor cell of mammary luminal epithelium	3 studies	66% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	43% ± 16%	Explore
lung	18 studies	53% ± 14%	Explore
intestine	13 studies	43% ± 17%	Explore
kidney	9 studies	46% ± 15%	Explore
eye	9 studies	49% ± 21%	Explore
brain	9 studies	33% ± 9%	Explore
lymph node	7 studies	52% ± 13%	Explore
liver	7 studies	49% ± 18%	Explore
bone marrow	6 studies	48% ± 21%	Explore
uterus	6 studies	56% ± 13%	Explore
pancreas	4 studies	57% ± 22%	Explore
placenta	4 studies	57% ± 15%	Explore
prostate	4 studies	57% ± 11%	Explore
breast	4 studies	66% ± 7%	Explore
ovary	3 studies	58% ± 5%	Explore
adrenal gland	3 studies	51% ± 13%	Explore
esophagus	3 studies	47% ± 6%	Explore
skin	3 studies	66% ± 7%	Explore
thymus	3 studies	75% ± 20%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6075.91	1445 / 1445	100%	162.02	183 / 183
skin	100%	7777.26	1809 / 1809	100%	402.18	472 / 472
uterus	100%	5117.31	170 / 170	100%	399.23	459 / 459
bladder	100%	6140.00	21 / 21	100%	283.99	503 / 504
ovary	100%	4681.18	180 / 180	100%	148.97	428 / 430
lung	100%	5486.77	576 / 578	100%	216.31	1152 / 1155
stomach	100%	4636.78	359 / 359	99%	204.49	284 / 286
intestine	100%	6610.70	966 / 966	99%	256.35	522 / 527
breast	100%	3796.29	459 / 459	99%	233.79	1107 / 1118
brain	99%	4228.21	2613 / 2642	100%	155.35	704 / 705
prostate	100%	4976.05	244 / 245	99%	114.23	496 / 502
thymus	100%	3368.02	652 / 653	98%	146.88	595 / 605
adrenal gland	100%	3110.65	257 / 258	97%	148.63	224 / 230
pancreas	97%	1663.11	319 / 328	98%	140.31	174 / 178
kidney	100%	3815.58	89 / 89	95%	92.11	856 / 901
liver	88%	1590.46	199 / 226	83%	97.15	339 / 406
eye	0%	0	0 / 0	100%	208.48	80 / 80
lymph node	0%	0	0 / 0	100%	405.41	29 / 29
spleen	100%	6285.72	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	423.39	45 / 45
ureter	0%	0	0 / 0	100%	157.95	1 / 1
blood vessel	100%	4766.47	1334 / 1335	0%	0	0 / 0
adipose	100%	3808.60	1202 / 1204	0%	0	0 / 0
muscle	99%	2608.64	791 / 803	0%	0	0 / 0
peripheral blood	98%	8422.05	915 / 929	0%	0	0 / 0
heart	96%	2261.56	824 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006325	Biological process	chromatin organization
GO_0071392	Biological process	cellular response to estradiol stimulus
GO_0031507	Biological process	heterochromatin formation
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0001740	Cellular component	Barr body
GO_0000792	Cellular component	heterochromatin
GO_0000791	Cellular component	euchromatin
GO_0070062	Cellular component	extracellular exosome
GO_0000786	Cellular component	nucleosome
GO_0005634	Cellular component	nucleus
GO_0030527	Molecular function	structural constituent of chromatin
GO_0000979	Molecular function	RNA polymerase II core promoter sequence-specific DNA binding
GO_0031490	Molecular function	chromatin DNA binding
GO_0031492	Molecular function	nucleosomal DNA binding
GO_0046982	Molecular function	protein heterodimerization activity
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	H2AZ1
Protein name	Histone H2A.Z (H2A/z) Histone H2A
Synonyms	H2AFZ H2AZ
Description	FUNCTION: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. .
Accessions	ENST00000651623.1 A0A494C189 P0C0S5 ENST00000296417.6

H2AZ1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review