FTH1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0048147Biological processnegative regulation of fibroblast proliferation
GO_0006880Biological processintracellular sequestering of iron ion
GO_0110076Biological processnegative regulation of ferroptosis
GO_0006826Biological processiron ion transport
GO_0006955Biological processimmune response
GO_0006879Biological processintracellular iron ion homeostasis
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0044754Cellular componentautolysosome
GO_0070062Cellular componentextracellular exosome
GO_0070288Cellular componentferritin complex
GO_1904724Cellular componenttertiary granule lumen
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004322Molecular functionferroxidase activity
GO_0008198Molecular functionferrous iron binding
GO_0042802Molecular functionidentical protein binding
GO_0005506Molecular functioniron ion binding
GO_0008199Molecular functionferric iron binding
GO_0140315Molecular functioniron ion sequestering activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFTH1
Protein nameFerritin heavy chain
Ferritin heavy chain (Ferritin H subunit) (EC 1.16.3.1) (Cell proliferation-inducing gene 15 protein) [Cleaved into: Ferritin heavy chain, N-terminally processed]
Ferritin
SynonymshCG_1776129
PIG15
FTH
OK/SW-cl.84
FTHL6
DescriptionFUNCTION: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity . Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation . Also plays a role in delivery of iron to cells (By similarity). Mediates iron uptake in capsule cells of the developing kidney (By similarity). .

FUNCTION: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. .

FUNCTION: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. .

FUNCTION: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. .

FUNCTION: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. .

FUNCTION: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. .

FUNCTION: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. .

FUNCTION: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. .

FUNCTION: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. .

FUNCTION: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. .

AccessionsE9PPQ4
ENST00000273550.12
P02794
ENST00000534180.1
E9PQR3
Q6NS36
G3V192
Q6NZ44
ENST00000529631.5
ENST00000532829.5
ENST00000526640.5
E9PK45
ENST00000530019.5
ENST00000532601.1
G3V1D1
E9PRK8
ENST00000529548.1
A9JQE1
ENST00000529191.5
E9PKY7
E9PKM5
ENST00000620041.5