EIF1AX report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006413Biological processtranslational initiation
GO_0042255Biological processribosome assembly
GO_0033290Cellular componenteukaryotic 48S preinitiation complex
GO_0043614Cellular componentmulti-eIF complex
GO_0005829Cellular componentcytosol
GO_0016282Cellular componenteukaryotic 43S preinitiation complex
GO_0005737Cellular componentcytoplasm
GO_0003743Molecular functiontranslation initiation factor activity
GO_0008135Molecular functiontranslation factor activity, RNA binding
GO_0000049Molecular functiontRNA binding
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameEIF1AX
Protein nameEukaryotic translation initiation factor 1A, X-chromosomal (eIF-1A X isoform) (eIF1A X isoform) (Eukaryotic translation initiation factor 4C) (eIF-4C)
Eukaryotic translation initiation factor 4C
Alternative protein EIF1AX
SynonymsEIF4C
EIF1A
DescriptionFUNCTION: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon . This protein enhances formation of the cap-proximal complex . Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes . After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex . Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B . Its globular part is located in the A site of the 40S ribosomal subunit . Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC . In contrast to yeast orthologs, does not bind EIF1 . .

FUNCTION: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. .

AccessionsX6RAC9
ENST00000379593.1
L8E8T0
ENST00000379607.10
P47813