CIRBP | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	47 studies	53% ± 22%	Explore
B cell	46 studies	65% ± 20%	Explore
fibroblast	45 studies	65% ± 23%	Explore
macrophage	43 studies	44% ± 15%	Explore
natural killer cell	43 studies	64% ± 18%	Explore
T cell	39 studies	54% ± 20%	Explore
CD8-positive, alpha-beta T cell	38 studies	58% ± 19%	Explore
pericyte	37 studies	67% ± 24%	Explore
CD4-positive, alpha-beta T cell	33 studies	63% ± 19%	Explore
smooth muscle cell	32 studies	68% ± 23%	Explore
conventional dendritic cell	29 studies	57% ± 15%	Explore
mast cell	28 studies	52% ± 23%	Explore
plasma cell	28 studies	55% ± 21%	Explore
regulatory T cell	28 studies	71% ± 13%	Explore
endothelial cell of lymphatic vessel	27 studies	60% ± 21%	Explore
dendritic cell	25 studies	58% ± 20%	Explore
classical monocyte	25 studies	45% ± 15%	Explore
plasmacytoid dendritic cell	25 studies	74% ± 16%	Explore
mature NK T cell	23 studies	59% ± 19%	Explore
non-classical monocyte	23 studies	63% ± 16%	Explore
epithelial cell	23 studies	60% ± 25%	Explore
basal cell	22 studies	64% ± 18%	Explore
monocyte	21 studies	44% ± 13%	Explore
astrocyte	21 studies	45% ± 20%	Explore
ciliated cell	20 studies	65% ± 20%	Explore
memory B cell	20 studies	75% ± 11%	Explore
naive B cell	20 studies	71% ± 14%	Explore
connective tissue cell	20 studies	67% ± 26%	Explore
gamma-delta T cell	19 studies	65% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	19 studies	64% ± 21%	Explore
CD16-negative, CD56-bright natural killer cell, human	17 studies	66% ± 22%	Explore
mucosal invariant T cell	16 studies	64% ± 20%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	70% ± 19%	Explore
oligodendrocyte	16 studies	39% ± 15%	Explore
microglial cell	16 studies	41% ± 19%	Explore
myofibroblast cell	15 studies	78% ± 18%	Explore
endothelial cell of vascular tree	15 studies	55% ± 21%	Explore
myeloid cell	15 studies	42% ± 19%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	75% ± 11%	Explore
oligodendrocyte precursor cell	14 studies	44% ± 22%	Explore
type I pneumocyte	13 studies	58% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	58% ± 23%	Explore
innate lymphoid cell	13 studies	64% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	67% ± 14%	Explore
capillary endothelial cell	13 studies	50% ± 15%	Explore
mesothelial cell	13 studies	61% ± 31%	Explore
vein endothelial cell	13 studies	54% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	67% ± 15%	Explore
secretory cell	12 studies	63% ± 18%	Explore
endothelial cell of artery	12 studies	58% ± 17%	Explore
type II pneumocyte	11 studies	63% ± 24%	Explore
plasmablast	11 studies	61% ± 22%	Explore
glutamatergic neuron	11 studies	38% ± 20%	Explore
goblet cell	11 studies	40% ± 15%	Explore
T follicular helper cell	10 studies	72% ± 17%	Explore
club cell	10 studies	55% ± 20%	Explore
leukocyte	10 studies	55% ± 15%	Explore
GABAergic neuron	10 studies	36% ± 18%	Explore
progenitor cell	10 studies	60% ± 26%	Explore
abnormal cell	10 studies	65% ± 20%	Explore
adipocyte	10 studies	38% ± 12%	Explore
platelet	9 studies	35% ± 7%	Explore
epithelial cell of proximal tubule	9 studies	43% ± 22%	Explore
IgG plasma cell	9 studies	42% ± 18%	Explore
hematopoietic stem cell	9 studies	68% ± 29%	Explore
kidney loop of Henle epithelial cell	8 studies	54% ± 26%	Explore
renal alpha-intercalated cell	8 studies	66% ± 28%	Explore
neuron	8 studies	67% ± 27%	Explore
IgA plasma cell	8 studies	47% ± 22%	Explore
retinal cone cell	8 studies	58% ± 26%	Explore
retinal rod cell	8 studies	60% ± 22%	Explore
alveolar macrophage	7 studies	45% ± 13%	Explore
ionocyte	7 studies	69% ± 12%	Explore
respiratory goblet cell	7 studies	50% ± 19%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	63% ± 9%	Explore
kidney distal convoluted tubule epithelial cell	7 studies	66% ± 30%	Explore
amacrine cell	7 studies	66% ± 24%	Explore
lymphocyte	7 studies	51% ± 29%	Explore
precursor B cell	7 studies	70% ± 18%	Explore
immature B cell	7 studies	76% ± 19%	Explore
erythrocyte	7 studies	49% ± 17%	Explore
interneuron	7 studies	50% ± 24%	Explore
CD4-positive helper T cell	6 studies	60% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	55% ± 20%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	67% ± 11%	Explore
mononuclear phagocyte	6 studies	55% ± 20%	Explore
erythroblast	6 studies	40% ± 24%	Explore
intestinal crypt stem cell	6 studies	41% ± 23%	Explore
transit amplifying cell	6 studies	35% ± 15%	Explore
retina horizontal cell	6 studies	72% ± 20%	Explore
retinal ganglion cell	6 studies	71% ± 30%	Explore
glial cell	6 studies	52% ± 23%	Explore
mucus secreting cell	6 studies	42% ± 14%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	69% ± 14%	Explore
hepatocyte	6 studies	38% ± 19%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	69% ± 10%	Explore
hematopoietic precursor cell	5 studies	73% ± 29%	Explore
exhausted T cell	5 studies	67% ± 7%	Explore
podocyte	5 studies	74% ± 27%	Explore
megakaryocyte	5 studies	60% ± 18%	Explore
enterocyte	5 studies	43% ± 15%	Explore
enteroendocrine cell	5 studies	68% ± 21%	Explore
renal principal cell	5 studies	56% ± 30%	Explore
pro-B cell	5 studies	69% ± 17%	Explore
brush cell	5 studies	51% ± 11%	Explore
neuroendocrine cell	5 studies	74% ± 25%	Explore
Schwann cell	5 studies	57% ± 28%	Explore
T-helper 17 cell	5 studies	70% ± 7%	Explore
group 3 innate lymphoid cell	5 studies	81% ± 8%	Explore
retinal pigment epithelial cell	5 studies	61% ± 24%	Explore
cardiac muscle cell	5 studies	30% ± 12%	Explore
Mueller cell	5 studies	60% ± 27%	Explore
keratinocyte	5 studies	58% ± 19%	Explore
melanocyte	5 studies	68% ± 13%	Explore
double negative thymocyte	5 studies	78% ± 7%	Explore
intermediate monocyte	5 studies	65% ± 20%	Explore
granulocyte	5 studies	67% ± 15%	Explore
deuterosomal cell	4 studies	32% ± 4%	Explore
duct epithelial cell	4 studies	52% ± 19%	Explore
squamous epithelial cell	4 studies	38% ± 24%	Explore
pancreatic A cell	4 studies	83% ± 11%	Explore
type B pancreatic cell	4 studies	85% ± 13%	Explore
glomerular endothelial cell	4 studies	54% ± 13%	Explore
retinal bipolar neuron	4 studies	74% ± 27%	Explore
OFF-bipolar cell	4 studies	68% ± 24%	Explore
ON-bipolar cell	4 studies	69% ± 23%	Explore
adventitial cell	4 studies	61% ± 11%	Explore
chondrocyte	4 studies	58% ± 28%	Explore
acinar cell	4 studies	49% ± 9%	Explore
muscle cell	4 studies	50% ± 18%	Explore
germinal center B cell	4 studies	64% ± 20%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	79% ± 15%	Explore
luminal cell of prostate epithelium	4 studies	55% ± 9%	Explore
IgM plasma cell	4 studies	40% ± 22%	Explore
neutrophil	4 studies	23% ± 4%	Explore
T-helper 1 cell	4 studies	74% ± 10%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	65% ± 11%	Explore
hillock cell	3 studies	35% ± 8%	Explore
precursor cell	3 studies	79% ± 15%	Explore
pancreatic D cell	3 studies	87% ± 8%	Explore
monocyte-derived dendritic cell	3 studies	59% ± 20%	Explore
kidney connecting tubule epithelial cell	3 studies	82% ± 11%	Explore
renal beta-intercalated cell	3 studies	93% ± 4%	Explore
parietal epithelial cell	3 studies	65% ± 28%	Explore
neural crest cell	3 studies	91% ± 6%	Explore
GABAergic amacrine cell	3 studies	70% ± 19%	Explore
glycinergic amacrine cell	3 studies	68% ± 22%	Explore
thymocyte	3 studies	56% ± 26%	Explore
extravillous trophoblast	3 studies	39% ± 14%	Explore
placental villous trophoblast	3 studies	67% ± 33%	Explore
serous secreting cell	3 studies	54% ± 0%	Explore
tissue-resident macrophage	3 studies	46% ± 20%	Explore
intraepithelial lymphocyte	3 studies	57% ± 14%	Explore
rod bipolar cell	3 studies	69% ± 22%	Explore
myoepithelial cell	3 studies	90% ± 1%	Explore
endothelial cell of sinusoid	3 studies	34% ± 11%	Explore
inflammatory macrophage	3 studies	39% ± 6%	Explore
pancreatic ductal cell	3 studies	70% ± 9%	Explore
ependymal cell	3 studies	37% ± 11%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	81% ± 18%	Explore
granule cell	3 studies	35% ± 14%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	77% ± 8%	Explore
double-positive, alpha-beta thymocyte	3 studies	83% ± 4%	Explore
progenitor cell of mammary luminal epithelium	3 studies	87% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	21 studies	36% ± 16%	Explore
lung	20 studies	57% ± 18%	Explore
peripheral blood	19 studies	65% ± 15%	Explore
intestine	12 studies	55% ± 25%	Explore
kidney	11 studies	50% ± 21%	Explore
eye	11 studies	61% ± 23%	Explore
lymph node	6 studies	65% ± 18%	Explore
heart	6 studies	27% ± 13%	Explore
liver	6 studies	45% ± 13%	Explore
pancreas	5 studies	67% ± 25%	Explore
bone marrow	5 studies	46% ± 25%	Explore
placenta	5 studies	47% ± 20%	Explore
uterus	5 studies	65% ± 25%	Explore
skin	5 studies	53% ± 25%	Explore
adipose	5 studies	38% ± 20%	Explore
breast	5 studies	63% ± 21%	Explore
esophagus	4 studies	44% ± 30%	Explore
prostate	4 studies	49% ± 11%	Explore
adrenal gland	3 studies	52% ± 18%	Explore
thymus	3 studies	65% ± 31%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
pancreas	100%	27780.07	328 / 328	100%	141.22	178 / 178
prostate	100%	36919.69	245 / 245	100%	267.56	502 / 502
thymus	100%	38882.48	653 / 653	100%	298.50	605 / 605
adrenal gland	100%	29495.41	258 / 258	100%	270.96	229 / 230
kidney	100%	23950.54	89 / 89	99%	142.92	896 / 901
breast	100%	30562.41	459 / 459	99%	159.56	1106 / 1118
brain	99%	24564.77	2610 / 2642	100%	279.34	705 / 705
uterus	100%	38784.02	170 / 170	99%	102.14	453 / 459
skin	98%	24096.48	1776 / 1809	99%	133.54	468 / 472
bladder	100%	26793.00	21 / 21	97%	96.60	487 / 504
lung	100%	21659.47	577 / 578	94%	86.76	1086 / 1155
intestine	100%	28267.11	966 / 966	91%	65.56	479 / 527
liver	97%	10363.33	219 / 226	94%	71.78	380 / 406
stomach	100%	24412.12	359 / 359	79%	45.54	227 / 286
ovary	100%	49336.54	180 / 180	79%	41.97	339 / 430
esophagus	100%	22756.58	1444 / 1445	75%	35.46	137 / 183
adipose	100%	23643.96	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	440.37	80 / 80
lymph node	0%	0	0 / 0	100%	181.56	29 / 29
spleen	100%	37142.03	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	106.17	1 / 1
blood vessel	100%	23431.97	1334 / 1335	0%	0	0 / 0
muscle	99%	15293.58	794 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	89.52	44 / 45
heart	97%	14872.60	839 / 861	0%	0	0 / 0
peripheral blood	91%	10434.20	844 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0009411	Biological process	response to UV
GO_0048255	Biological process	mRNA stabilization
GO_0034063	Biological process	stress granule assembly
GO_0009409	Biological process	response to cold
GO_0048026	Biological process	positive regulation of mRNA splicing, via spliceosome
GO_0045727	Biological process	positive regulation of translation
GO_0017148	Biological process	negative regulation of translation
GO_0005654	Cellular component	nucleoplasm
GO_0010494	Cellular component	cytoplasmic stress granule
GO_0005681	Cellular component	spliceosomal complex
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0030371	Molecular function	translation repressor activity
GO_0070181	Molecular function	small ribosomal subunit rRNA binding
GO_0003730	Molecular function	mRNA 3'-UTR binding
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	CIRBP
Protein name	Cold-inducible RNA-binding protein (Glycine-rich RNA-binding protein CIRP) Cold inducible RNA binding protein Cold-inducible RNA-binding protein (A18 hnRNP) (Glycine-rich RNA-binding protein CIRP)
Synonyms	A18HNRNP CIRP hCG_21575
Description	FUNCTION: Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed. .
Accessions	ENST00000413636.6 [Q14011-2] ENST00000591376.5 Q53XX5 ENST00000587896.6 K7EQL0 ENST00000586548.5 ENST00000586472.5 [Q14011-1] ENST00000588344.2 ENST00000587323.5 K7EIF7 K7EJV1 ENST00000444172.6 F6WMK9 ENST00000589686.5 K7ELL4 K7ELV6 ENST00000585913.5 ENST00000591055.5 K7ELT6 ENST00000320936.9 [Q14011-1] K7EPM4 ENST00000586636.5 ENST00000586773.5 ENST00000592412.5 ENST00000592051.1 K7EMY9 ENST00000591659.5 ENST00000588411.5 K7ER40 D6W5Y5 ENST00000590347.5 ENST00000585630.5 [Q14011-1] ENST00000591097.5 ENST00000590171.1 ENST00000588030.5 [Q14011-1] K7EJV5 Q14011 K7EQX4 ENST00000585914.5 ENST00000588090.5 [Q14011-1] ENST00000592234.5 ENST00000592815.5 ENST00000589266.5 K7EQR7 K7ENX8 ENST00000587169.5 K7ENN6 ENST00000589710.5 ENST00000593048.5 ENST00000589235.5 ENST00000588230.5 ENST00000591935.5 ENST00000628979.2

CIRBP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review