BANF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0045071Biological processnegative regulation of viral genome replication
GO_0015074Biological processDNA integration
GO_0009615Biological processresponse to virus
GO_0160049Biological processnegative regulation of cGAS/STING signaling pathway
GO_0010836Biological processnegative regulation of protein ADP-ribosylation
GO_0032480Biological processnegative regulation of type I interferon production
GO_0045824Biological processnegative regulation of innate immune response
GO_0051276Biological processchromosome organization
GO_0007084Biological processmitotic nuclear membrane reassembly
GO_0006979Biological processresponse to oxidative stress
GO_0005654Cellular componentnucleoplasm
GO_0005635Cellular componentnuclear envelope
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000793Cellular componentcondensed chromosome
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBANF1
Protein nameBarrier-to-autointegration factor (Breakpoint cluster region protein 1) [Cleaved into: Barrier-to-autointegration factor, N-terminally processed]
BAF nuclear assembly factor 1
SynonymsBAF
BCRG1
DescriptionFUNCTION: Non-specific DNA-binding protein that plays key roles in mitotic nuclear reassembly, chromatin organization, DNA damage response, gene expression and intrinsic immunity against foreign DNA . Contains two non-specific double-stranded DNA (dsDNA)-binding sites which promote DNA cross-bridging . Plays a key role in nuclear membrane reformation at the end of mitosis by driving formation of a single nucleus in a spindle-independent manner . Transiently cross-bridges anaphase chromosomes via its ability to bridge distant DNA sites, leading to the formation of a dense chromatin network at the chromosome ensemble surface that limits membranes to the surface . Also acts as a negative regulator of innate immune activation by restricting CGAS activity toward self-DNA upon acute loss of nuclear membrane integrity . Outcompetes CGAS for DNA-binding, thereby preventing CGAS activation and subsequent damaging autoinflammatory responses . Also involved in DNA damage response: interacts with PARP1 in response to oxidative stress, thereby inhibiting the ADP-ribosyltransferase activity of PARP1 . Involved in the recognition of exogenous dsDNA in the cytosol: associates with exogenous dsDNA immediately after its appearance in the cytosol at endosome breakdown and is required to avoid autophagy . In case of poxvirus infection, has an antiviral activity by blocking viral DNA replication . .; FUNCTION: (Microbial infection) Exploited by retroviruses for inhibiting self-destructing autointegration of retroviral DNA, thereby promoting integration of viral DNA into the host chromosome . EMD and BAF are cooperative cofactors of HIV-1 infection . Association of EMD with the viral DNA requires the presence of BAF and viral integrase . The association of viral DNA with chromatin requires the presence of BAF and EMD . .

AccessionsENST00000312175.7
ENST00000530204.1
ENST00000445560.6
ENST00000527348.1
E9PJJ8
ENST00000533166.5
O75531