VDAC2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	34 studies	33% ± 14%	Explore
fibroblast	34 studies	39% ± 14%	Explore
B cell	33 studies	31% ± 9%	Explore
natural killer cell	33 studies	30% ± 10%	Explore
pericyte	28 studies	44% ± 14%	Explore
macrophage	27 studies	35% ± 11%	Explore
conventional dendritic cell	27 studies	41% ± 14%	Explore
CD4-positive, alpha-beta T cell	27 studies	35% ± 13%	Explore
CD8-positive, alpha-beta T cell	27 studies	32% ± 13%	Explore
T cell	24 studies	30% ± 11%	Explore
smooth muscle cell	24 studies	47% ± 15%	Explore
non-classical monocyte	22 studies	39% ± 15%	Explore
epithelial cell	22 studies	50% ± 21%	Explore
classical monocyte	22 studies	32% ± 12%	Explore
regulatory T cell	21 studies	36% ± 9%	Explore
dendritic cell	20 studies	47% ± 21%	Explore
basal cell	20 studies	54% ± 16%	Explore
memory B cell	19 studies	30% ± 8%	Explore
monocyte	17 studies	32% ± 8%	Explore
plasmacytoid dendritic cell	17 studies	34% ± 12%	Explore
naive B cell	17 studies	27% ± 6%	Explore
connective tissue cell	17 studies	42% ± 14%	Explore
mast cell	16 studies	34% ± 13%	Explore
endothelial cell of lymphatic vessel	16 studies	41% ± 10%	Explore
gamma-delta T cell	16 studies	32% ± 14%	Explore
mature NK T cell	15 studies	29% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	31% ± 10%	Explore
ciliated cell	13 studies	42% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	30% ± 7%	Explore
myofibroblast cell	13 studies	48% ± 12%	Explore
plasma cell	12 studies	41% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	31% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	33% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	34% ± 7%	Explore
capillary endothelial cell	11 studies	30% ± 10%	Explore
vein endothelial cell	11 studies	30% ± 11%	Explore
endothelial cell of vascular tree	11 studies	35% ± 8%	Explore
plasmablast	10 studies	47% ± 22%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	30% ± 10%	Explore
secretory cell	10 studies	47% ± 18%	Explore
abnormal cell	10 studies	44% ± 19%	Explore
endothelial cell of artery	10 studies	34% ± 8%	Explore
astrocyte	10 studies	27% ± 15%	Explore
myeloid cell	10 studies	37% ± 11%	Explore
goblet cell	9 studies	37% ± 13%	Explore
mucosal invariant T cell	9 studies	33% ± 6%	Explore
type I pneumocyte	8 studies	32% ± 13%	Explore
leukocyte	8 studies	34% ± 11%	Explore
progenitor cell	8 studies	51% ± 12%	Explore
enterocyte	8 studies	43% ± 17%	Explore
club cell	7 studies	40% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	35% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	33% ± 9%	Explore
transit amplifying cell	7 studies	31% ± 16%	Explore
retinal rod cell	7 studies	33% ± 18%	Explore
neuron	7 studies	51% ± 28%	Explore
T follicular helper cell	7 studies	28% ± 4%	Explore
alveolar macrophage	6 studies	38% ± 15%	Explore
epithelial cell of proximal tubule	6 studies	39% ± 13%	Explore
kidney loop of Henle epithelial cell	6 studies	46% ± 14%	Explore
renal alpha-intercalated cell	6 studies	64% ± 10%	Explore
intestinal crypt stem cell	6 studies	37% ± 18%	Explore
mesothelial cell	6 studies	54% ± 15%	Explore
retinal ganglion cell	6 studies	59% ± 34%	Explore
retinal cone cell	6 studies	48% ± 24%	Explore
hematopoietic stem cell	6 studies	50% ± 14%	Explore
precursor B cell	6 studies	40% ± 11%	Explore
innate lymphoid cell	6 studies	29% ± 4%	Explore
hematopoietic precursor cell	5 studies	50% ± 27%	Explore
respiratory goblet cell	5 studies	38% ± 23%	Explore
platelet	5 studies	18% ± 3%	Explore
mononuclear phagocyte	5 studies	41% ± 16%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	56% ± 13%	Explore
microglial cell	5 studies	26% ± 12%	Explore
pro-B cell	5 studies	40% ± 8%	Explore
brush cell	5 studies	29% ± 23%	Explore
immature B cell	5 studies	38% ± 18%	Explore
type II pneumocyte	5 studies	36% ± 13%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	41% ± 13%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	38% ± 11%	Explore
granulocyte	5 studies	33% ± 9%	Explore
GABAergic neuron	5 studies	30% ± 8%	Explore
oligodendrocyte precursor cell	5 studies	34% ± 16%	Explore
ionocyte	4 studies	51% ± 9%	Explore
pancreatic A cell	4 studies	62% ± 9%	Explore
type B pancreatic cell	4 studies	58% ± 18%	Explore
exhausted T cell	4 studies	38% ± 8%	Explore
enteroendocrine cell	4 studies	55% ± 13%	Explore
OFF-bipolar cell	4 studies	47% ± 27%	Explore
ON-bipolar cell	4 studies	48% ± 28%	Explore
erythroblast	4 studies	40% ± 20%	Explore
amacrine cell	4 studies	52% ± 20%	Explore
retina horizontal cell	4 studies	49% ± 17%	Explore
adventitial cell	4 studies	31% ± 12%	Explore
Mueller cell	4 studies	38% ± 12%	Explore
muscle cell	4 studies	33% ± 20%	Explore
intermediate monocyte	4 studies	45% ± 19%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	43% ± 9%	Explore
glutamatergic neuron	4 studies	39% ± 7%	Explore
erythrocyte	4 studies	42% ± 19%	Explore
keratinocyte	4 studies	47% ± 19%	Explore
T-helper 17 cell	4 studies	37% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	24% ± 7%	Explore
deuterosomal cell	3 studies	22% ± 6%	Explore
duct epithelial cell	3 studies	33% ± 4%	Explore
precursor cell	3 studies	62% ± 8%	Explore
squamous epithelial cell	3 studies	51% ± 23%	Explore
pancreatic D cell	3 studies	57% ± 17%	Explore
monocyte-derived dendritic cell	3 studies	43% ± 21%	Explore
glomerular endothelial cell	3 studies	24% ± 6%	Explore
neural crest cell	3 studies	54% ± 11%	Explore
retinal bipolar neuron	3 studies	54% ± 20%	Explore
GABAergic amacrine cell	3 studies	34% ± 11%	Explore
glycinergic amacrine cell	3 studies	31% ± 10%	Explore
renal principal cell	3 studies	43% ± 12%	Explore
extravillous trophoblast	3 studies	67% ± 13%	Explore
placental villous trophoblast	3 studies	70% ± 7%	Explore
lymphocyte	3 studies	44% ± 5%	Explore
megakaryocyte	3 studies	34% ± 10%	Explore
neuroendocrine cell	3 studies	55% ± 17%	Explore
retinal pigment epithelial cell	3 studies	35% ± 25%	Explore
mucus secreting cell	3 studies	34% ± 6%	Explore
serous secreting cell	3 studies	41% ± 10%	Explore
intraepithelial lymphocyte	3 studies	33% ± 14%	Explore
rod bipolar cell	3 studies	51% ± 14%	Explore
cardiac muscle cell	3 studies	30% ± 10%	Explore
germinal center B cell	3 studies	37% ± 4%	Explore
myoepithelial cell	3 studies	49% ± 2%	Explore
acinar cell	3 studies	53% ± 18%	Explore
pancreatic ductal cell	3 studies	75% ± 5%	Explore
granulocyte monocyte progenitor cell	3 studies	40% ± 25%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	62% ± 22%	Explore
glial cell	3 studies	43% ± 23%	Explore
hepatocyte	3 studies	38% ± 21%	Explore
group 3 innate lymphoid cell	3 studies	44% ± 13%	Explore
interneuron	3 studies	33% ± 6%	Explore
oligodendrocyte	3 studies	21% ± 5%	Explore
T-helper 1 cell	3 studies	39% ± 6%	Explore
double negative thymocyte	3 studies	49% ± 18%	Explore
progenitor cell of mammary luminal epithelium	3 studies	47% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	42% ± 14%	Explore
peripheral blood	16 studies	35% ± 11%	Explore
intestine	12 studies	35% ± 17%	Explore
eye	10 studies	36% ± 16%	Explore
kidney	9 studies	34% ± 12%	Explore
brain	9 studies	26% ± 8%	Explore
liver	5 studies	33% ± 20%	Explore
lymph node	5 studies	40% ± 12%	Explore
pancreas	4 studies	61% ± 12%	Explore
bone marrow	4 studies	26% ± 7%	Explore
uterus	4 studies	46% ± 13%	Explore
prostate	4 studies	39% ± 17%	Explore
breast	4 studies	38% ± 6%	Explore
placenta	3 studies	58% ± 9%	Explore
adrenal gland	3 studies	32% ± 11%	Explore
esophagus	3 studies	57% ± 28%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	8858.63	1445 / 1445	100%	161.41	183 / 183
ovary	100%	5209.11	180 / 180	100%	200.78	430 / 430
intestine	100%	7362.14	966 / 966	100%	105.43	526 / 527
stomach	100%	5166.87	359 / 359	100%	112.42	285 / 286
breast	100%	4956.80	459 / 459	100%	83.88	1114 / 1118
uterus	100%	4878.05	170 / 170	100%	108.99	457 / 459
skin	100%	6836.14	1808 / 1809	100%	77.15	470 / 472
bladder	100%	6758.57	21 / 21	99%	83.97	501 / 504
lung	99%	4631.01	575 / 578	100%	98.56	1153 / 1155
pancreas	99%	3716.10	325 / 328	100%	70.59	178 / 178
thymus	100%	3997.04	651 / 653	99%	68.98	601 / 605
kidney	100%	5102.06	89 / 89	99%	73.35	892 / 901
prostate	100%	4128.07	244 / 245	99%	70.22	498 / 502
brain	98%	4309.42	2601 / 2642	100%	82.46	705 / 705
adrenal gland	100%	5831.08	258 / 258	98%	80.37	226 / 230
liver	81%	1833.37	184 / 226	98%	45.83	396 / 406
adipose	100%	5469.05	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	121.47	80 / 80
lymph node	0%	0	0 / 0	100%	75.94	29 / 29
muscle	100%	12061.29	803 / 803	0%	0	0 / 0
spleen	100%	3190.17	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	119.68	45 / 45
ureter	0%	0	0 / 0	100%	38.18	1 / 1
blood vessel	100%	5935.28	1334 / 1335	0%	0	0 / 0
heart	97%	9837.10	833 / 861	0%	0	0 / 0
peripheral blood	84%	3321.56	781 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007339	Biological process	binding of sperm to zona pellucida
GO_0098656	Biological process	monoatomic anion transmembrane transport
GO_0032272	Biological process	negative regulation of protein polymerization
GO_0097345	Biological process	mitochondrial outer membrane permeabilization
GO_0006820	Biological process	monoatomic anion transport
GO_2001243	Biological process	negative regulation of intrinsic apoptotic signaling pathway
GO_0001669	Cellular component	acrosomal vesicle
GO_0042645	Cellular component	mitochondrial nucleoid
GO_0016020	Cellular component	membrane
GO_0005739	Cellular component	mitochondrion
GO_0031966	Cellular component	mitochondrial membrane
GO_0046930	Cellular component	pore complex
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0097225	Cellular component	sperm midpiece
GO_0005634	Cellular component	nucleus
GO_0015288	Molecular function	porin activity
GO_0015485	Molecular function	cholesterol binding
GO_0097001	Molecular function	ceramide binding
GO_0008308	Molecular function	voltage-gated monoatomic anion channel activity
GO_0000166	Molecular function	nucleotide binding
GO_0031210	Molecular function	phosphatidylcholine binding
GO_0008142	Molecular function	oxysterol binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	VDAC2
Protein name	Voltage-dependent anion-selective channel protein 2 (Outer mitochondrial membrane protein porin 2) Voltage-dependent anion-selective channel protein 2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2)
Synonyms	hCG_23984
Description	FUNCTION: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity). The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (By similarity). The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol . Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway . .
Accessions	ENST00000447677.5 ENST00000298468.9 Q5JSD2 ENST00000344036.8 A0A024QZT0 ENST00000413289.1 ENST00000313132.8 [P45880-1] ENST00000543351.5 [P45880-3] Q5JSD1 A0A0A0MR02 ENST00000332211.11 [P45880-3] P45880 A2A3S1

VDAC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review