UQCRH report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006122Biological processmitochondrial electron transport, ubiquinol to cytochrome c
GO_0006119Biological processoxidative phosphorylation
GO_0009060Biological processaerobic respiration
GO_0045333Biological processcellular respiration
GO_1902600Biological processproton transmembrane transport
GO_0005746Cellular componentmitochondrial respirasome
GO_0005750Cellular componentmitochondrial respiratory chain complex III
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005739Cellular componentmitochondrion
GO_0008121Molecular functionubiquinol-cytochrome-c reductase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUQCRH
Protein nameCytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein)
Ubiquinol-cytochrome c reductase hinge protein
SynonymshCG_22091
DescriptionFUNCTION: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. .

AccessionsA0A087WTF2
P07919
ENST00000496387.5
ENST00000489056.5
ENST00000311672.10
Q567R0
A0A087X2B9