UBXN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032435Biological processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_2000157Biological processnegative regulation of ubiquitin-specific protease activity
GO_1904293Biological processnegative regulation of ERAD pathway
GO_1903094Biological processnegative regulation of protein K48-linked deubiquitination
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0034098Cellular componentVCP-NPL4-UFD1 AAA ATPase complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1904855Molecular functionproteasome regulatory particle binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0036435Molecular functionK48-linked polyubiquitin modification-dependent protein binding
GO_0051117Molecular functionATPase binding
GO_0031593Molecular functionpolyubiquitin modification-dependent protein binding
GO_0071796Molecular functionK6-linked polyubiquitin modification-dependent protein binding
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameUBXN1
Protein nameUBX domain protein 1
UBXN1 protein (cDNA FLJ30270 fis, clone BRACE2002661, highly similar to UBA/UBX 33.3 kDa protein)
UBX domain-containing protein 1 (SAPK substrate protein 1) (UBA/UBX 33.3 kDa protein)
SynonymsSAKS1
LOC51035
hCG_1818009
DescriptionFUNCTION: Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling . Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibiting their recruitment to TNFR1 . Prevents also the activation of NF-kappa-B by associating with CUL1 and thus inhibiting NF-kappa-B inhibitor alpha/NFKBIA degradation that remains bound to NF-kappa-B . Interacts with the BRCA1-BARD1 heterodimer and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1 leads to the inhibition of the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer . Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. .

AccessionsENST00000533000.5
Q04323
E9PRQ7
Q05BV2
ENST00000529640.5
E9PS08
ENST00000616865.4
ENST00000301935.10 [Q04323-1]
E9PJ81
A0A087WTZ5
ENST00000534176.1
ENST00000294119.6 [Q04323-2]