UBB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097009Biological processenergy homeostasis
GO_0016567Biological processprotein ubiquitination
GO_0021888Biological processhypothalamus gonadotrophin-releasing hormone neuron development
GO_0047497Biological processmitochondrion transport along microtubule
GO_1902255Biological processpositive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO_1902527Biological processpositive regulation of protein monoubiquitination
GO_0072520Biological processseminiferous tubule development
GO_0043523Biological processregulation of neuron apoptotic process
GO_0019941Biological processmodification-dependent protein catabolic process
GO_0007141Biological processmale meiosis I
GO_0048812Biological processneuron projection morphogenesis
GO_0051881Biological processregulation of mitochondrial membrane potential
GO_0060613Biological processfat pad development
GO_0007144Biological processfemale meiosis I
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0008585Biological processfemale gonad development
GO_0061136Biological processregulation of proteasomal protein catabolic process
GO_0005615Cellular componentextracellular space
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0030666Cellular componentendocytic vesicle membrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0043025Cellular componentneuronal cell body
GO_0043005Cellular componentneuron projection
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005741Cellular componentmitochondrial outer membrane
GO_0010008Cellular componentendosome membrane
GO_0031982Cellular componentvesicle
GO_0005634Cellular componentnucleus
GO_0031386Molecular functionprotein tag activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUBB
Protein namePolyubiquitin-B [Cleaved into: Ubiquitin]
Epididymis secretory protein Li 50 (Ubiquitin B)
Ubiquitin B
SynonymshCG_1998947
HEL-S-50
DescriptionFUNCTION: [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. .

AccessionsENST00000302182.8
ENST00000614404.1
B4DV12
J3QS39
ENST00000395839.5
ENST00000395837.1
ENST00000577640.1
ENST00000535788.1
J3QKN0
P0CG47
Q5U5U6
J3QSA3
ENST00000577958.1
ENST00000578706.5