TSPO | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	32 studies	57% ± 21%	Explore
natural killer cell	30 studies	36% ± 11%	Explore
endothelial cell	29 studies	44% ± 17%	Explore
classical monocyte	28 studies	82% ± 16%	Explore
CD8-positive, alpha-beta T cell	28 studies	36% ± 15%	Explore
fibroblast	27 studies	36% ± 17%	Explore
conventional dendritic cell	25 studies	61% ± 20%	Explore
T cell	24 studies	35% ± 11%	Explore
non-classical monocyte	24 studies	80% ± 18%	Explore
regulatory T cell	24 studies	42% ± 19%	Explore
CD4-positive, alpha-beta T cell	24 studies	41% ± 17%	Explore
monocyte	23 studies	69% ± 23%	Explore
dendritic cell	22 studies	50% ± 26%	Explore
basal cell	22 studies	61% ± 24%	Explore
B cell	21 studies	26% ± 7%	Explore
smooth muscle cell	21 studies	34% ± 12%	Explore
epithelial cell	20 studies	54% ± 21%	Explore
endothelial cell of lymphatic vessel	19 studies	55% ± 13%	Explore
mature NK T cell	17 studies	38% ± 12%	Explore
gamma-delta T cell	17 studies	31% ± 10%	Explore
pericyte	17 studies	36% ± 13%	Explore
mast cell	16 studies	42% ± 14%	Explore
ciliated cell	16 studies	47% ± 21%	Explore
naive B cell	16 studies	23% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	34% ± 11%	Explore
myeloid cell	15 studies	57% ± 26%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	39% ± 12%	Explore
neutrophil	13 studies	56% ± 22%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	41% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	38% ± 13%	Explore
endothelial cell of artery	12 studies	50% ± 16%	Explore
mucosal invariant T cell	12 studies	32% ± 8%	Explore
memory B cell	11 studies	23% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	34% ± 18%	Explore
secretory cell	11 studies	60% ± 22%	Explore
connective tissue cell	11 studies	36% ± 12%	Explore
capillary endothelial cell	11 studies	38% ± 11%	Explore
vein endothelial cell	11 studies	46% ± 13%	Explore
endothelial cell of vascular tree	11 studies	45% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	44% ± 20%	Explore
plasmacytoid dendritic cell	10 studies	29% ± 12%	Explore
goblet cell	10 studies	46% ± 21%	Explore
mesothelial cell	10 studies	41% ± 16%	Explore
plasma cell	9 studies	37% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	38% ± 11%	Explore
alveolar macrophage	8 studies	68% ± 33%	Explore
type I pneumocyte	8 studies	49% ± 11%	Explore
innate lymphoid cell	8 studies	37% ± 13%	Explore
mononuclear phagocyte	8 studies	43% ± 21%	Explore
abnormal cell	8 studies	40% ± 24%	Explore
myofibroblast cell	8 studies	26% ± 9%	Explore
type II pneumocyte	7 studies	46% ± 14%	Explore
club cell	7 studies	66% ± 13%	Explore
ionocyte	7 studies	54% ± 17%	Explore
leukocyte	7 studies	33% ± 5%	Explore
T follicular helper cell	7 studies	34% ± 10%	Explore
respiratory goblet cell	6 studies	55% ± 18%	Explore
plasmablast	6 studies	45% ± 17%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	57% ± 26%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	49% ± 18%	Explore
transit amplifying cell	6 studies	51% ± 28%	Explore
hematopoietic stem cell	6 studies	51% ± 14%	Explore
progenitor cell	6 studies	63% ± 22%	Explore
intermediate monocyte	6 studies	76% ± 24%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	48% ± 21%	Explore
granulocyte	6 studies	47% ± 17%	Explore
CD4-positive helper T cell	5 studies	25% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	36% ± 15%	Explore
hematopoietic precursor cell	5 studies	61% ± 16%	Explore
platelet	5 studies	35% ± 22%	Explore
kidney loop of Henle epithelial cell	5 studies	34% ± 11%	Explore
renal alpha-intercalated cell	5 studies	65% ± 5%	Explore
enterocyte	5 studies	38% ± 15%	Explore
microglial cell	5 studies	55% ± 19%	Explore
duct epithelial cell	4 studies	67% ± 4%	Explore
squamous epithelial cell	4 studies	44% ± 26%	Explore
exhausted T cell	4 studies	56% ± 13%	Explore
glomerular endothelial cell	4 studies	35% ± 6%	Explore
intestinal crypt stem cell	4 studies	58% ± 15%	Explore
brush cell	4 studies	39% ± 23%	Explore
adventitial cell	4 studies	28% ± 10%	Explore
mucus secreting cell	4 studies	54% ± 15%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	53% ± 8%	Explore
erythrocyte	4 studies	46% ± 20%	Explore
keratinocyte	4 studies	60% ± 26%	Explore
melanocyte	4 studies	66% ± 24%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	51% ± 24%	Explore
deuterosomal cell	3 studies	28% ± 9%	Explore
hillock cell	3 studies	62% ± 30%	Explore
monocyte-derived dendritic cell	3 studies	64% ± 34%	Explore
renal principal cell	3 studies	50% ± 6%	Explore
extravillous trophoblast	3 studies	45% ± 15%	Explore
common myeloid progenitor	3 studies	59% ± 28%	Explore
erythroblast	3 studies	35% ± 12%	Explore
lymphocyte	3 studies	57% ± 5%	Explore
neuroendocrine cell	3 studies	32% ± 16%	Explore
astrocyte	3 studies	38% ± 17%	Explore
serous secreting cell	3 studies	50% ± 10%	Explore
Mueller cell	3 studies	29% ± 8%	Explore
myoepithelial cell	3 studies	42% ± 11%	Explore
luminal cell of prostate epithelium	3 studies	42% ± 10%	Explore
enteroendocrine cell	3 studies	29% ± 8%	Explore
glial cell	3 studies	34% ± 12%	Explore
group 3 innate lymphoid cell	3 studies	44% ± 6%	Explore
T-helper 17 cell	3 studies	52% ± 27%	Explore
T-helper 1 cell	3 studies	54% ± 23%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	47% ± 9%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	38% ± 14%	Explore
double negative thymocyte	3 studies	42% ± 9%	Explore
progenitor cell of mammary luminal epithelium	3 studies	63% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	19 studies	50% ± 13%	Explore
lung	18 studies	47% ± 18%	Explore
intestine	8 studies	32% ± 21%	Explore
kidney	8 studies	33% ± 15%	Explore
placenta	5 studies	27% ± 7%	Explore
lymph node	5 studies	35% ± 27%	Explore
bone marrow	4 studies	40% ± 13%	Explore
uterus	4 studies	54% ± 15%	Explore
prostate	4 studies	39% ± 16%	Explore
breast	4 studies	47% ± 8%	Explore
liver	4 studies	36% ± 9%	Explore
adrenal gland	3 studies	28% ± 8%	Explore
esophagus	3 studies	59% ± 26%	Explore
brain	3 studies	39% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	4531.77	245 / 245	99%	348.74	498 / 502
skin	100%	12546.72	1809 / 1809	99%	456.64	467 / 472
uterus	100%	3619.35	170 / 170	99%	405.91	454 / 459
stomach	99%	5672.73	357 / 359	98%	333.31	281 / 286
bladder	100%	4620.81	21 / 21	98%	457.97	492 / 504
lung	99%	6574.03	574 / 578	98%	287.76	1127 / 1155
breast	100%	7160.89	459 / 459	96%	245.18	1078 / 1118
esophagus	98%	9618.02	1411 / 1445	98%	234.71	180 / 183
intestine	97%	4581.94	936 / 966	99%	414.93	521 / 527
kidney	98%	3768.62	87 / 89	98%	186.42	879 / 901
thymus	95%	2852.13	620 / 653	97%	191.57	588 / 605
ovary	84%	2202.16	151 / 180	98%	247.05	421 / 430
pancreas	63%	1443.50	206 / 328	94%	430.17	168 / 178
adrenal gland	100%	5431.78	258 / 258	53%	77.71	122 / 230
liver	43%	994.70	97 / 226	65%	115.18	262 / 406
adipose	100%	7954.09	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	416.03	80 / 80
lymph node	0%	0	0 / 0	100%	400.44	29 / 29
spleen	100%	7042.22	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	547.73	45 / 45
ureter	0%	0	0 / 0	100%	751.43	1 / 1
peripheral blood	99%	26367.80	921 / 929	0%	0	0 / 0
blood vessel	99%	5901.79	1322 / 1335	0%	0	0 / 0
brain	23%	472.82	603 / 2642	73%	103.97	516 / 705
heart	94%	3303.71	807 / 861	0%	0	0 / 0
muscle	58%	1196.05	464 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0033574	Biological process	response to testosterone
GO_0051901	Biological process	positive regulation of mitochondrial depolarization
GO_0010042	Biological process	response to manganese ion
GO_0071476	Biological process	cellular hypotonic response
GO_0006821	Biological process	chloride transport
GO_0032374	Biological process	regulation of cholesterol transport
GO_0015918	Biological process	sterol transport
GO_0060252	Biological process	positive regulation of glial cell proliferation
GO_0060242	Biological process	contact inhibition
GO_0071294	Biological process	cellular response to zinc ion
GO_2000853	Biological process	negative regulation of corticosterone secretion
GO_0045019	Biological process	negative regulation of nitric oxide biosynthetic process
GO_0006783	Biological process	heme biosynthetic process
GO_0014012	Biological process	peripheral nervous system axon regeneration
GO_0010266	Biological process	response to vitamin B1
GO_0062100	Biological process	positive regulation of programmed necrotic cell death
GO_0050810	Biological process	regulation of steroid biosynthetic process
GO_0042632	Biological process	cholesterol homeostasis
GO_0006700	Biological process	C21-steroid hormone biosynthetic process
GO_1905144	Biological process	response to acetylcholine
GO_1901525	Biological process	negative regulation of mitophagy
GO_0006820	Biological process	monoatomic anion transport
GO_0072656	Biological process	maintenance of protein location in mitochondrion
GO_0060253	Biological process	negative regulation of glial cell proliferation
GO_2000379	Biological process	positive regulation of reactive oxygen species metabolic process
GO_0030325	Biological process	adrenal gland development
GO_1903579	Biological process	negative regulation of ATP metabolic process
GO_0008347	Biological process	glial cell migration
GO_0051928	Biological process	positive regulation of calcium ion transport
GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0048266	Biological process	behavioral response to pain
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0032720	Biological process	negative regulation of tumor necrosis factor production
GO_0006626	Biological process	protein targeting to mitochondrion
GO_0008202	Biological process	steroid metabolic process
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0032570	Biological process	response to progesterone
GO_0042127	Biological process	regulation of cell population proliferation
GO_0031397	Biological process	negative regulation of protein ubiquitination
GO_0016020	Cellular component	membrane
GO_0005739	Cellular component	mitochondrion
GO_0070062	Cellular component	extracellular exosome
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0015485	Molecular function	cholesterol binding
GO_0120020	Molecular function	cholesterol transfer activity
GO_0005497	Molecular function	androgen binding
GO_0044325	Molecular function	transmembrane transporter binding
GO_0005515	Molecular function	protein binding
GO_0008503	Molecular function	benzodiazepine receptor activity

IV. Literature review

[source]

Gene name	TSPO
Protein name	Putative peripheral benzodiazepine receptor-related protein Translocator protein (Peripheral-type benzodiazepine receptor) Translocator protein (Mitochondrial benzodiazepine receptor) (PKBS) (Peripheral-type benzodiazepine receptor) (PBR)
Synonyms	MBR BZRP PBRS
Description	FUNCTION: Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism , but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides . .
Accessions	J3QLD3 P30536 ENST00000329563.8 [P30536-1] B1AH87 B1AH88 ENST00000337554.8 [P30536-1] ENST00000396265.4 [P30536-1] ENST00000583777.5 ENST00000428336.5

TSPO report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review