TPI1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	41 studies	52% ± 21%	Explore
macrophage	40 studies	60% ± 22%	Explore
natural killer cell	39 studies	59% ± 18%	Explore
B cell	38 studies	42% ± 15%	Explore
fibroblast	38 studies	59% ± 21%	Explore
CD8-positive, alpha-beta T cell	36 studies	52% ± 22%	Explore
T cell	34 studies	51% ± 19%	Explore
pericyte	32 studies	62% ± 21%	Explore
CD4-positive, alpha-beta T cell	32 studies	50% ± 21%	Explore
conventional dendritic cell	29 studies	77% ± 15%	Explore
classical monocyte	28 studies	63% ± 19%	Explore
smooth muscle cell	26 studies	60% ± 20%	Explore
regulatory T cell	26 studies	54% ± 19%	Explore
dendritic cell	25 studies	65% ± 24%	Explore
epithelial cell	25 studies	68% ± 22%	Explore
non-classical monocyte	24 studies	77% ± 15%	Explore
mast cell	21 studies	50% ± 20%	Explore
monocyte	21 studies	64% ± 21%	Explore
mature NK T cell	21 studies	48% ± 18%	Explore
basal cell	21 studies	69% ± 19%	Explore
memory B cell	20 studies	46% ± 13%	Explore
endothelial cell of lymphatic vessel	19 studies	62% ± 15%	Explore
plasma cell	19 studies	47% ± 19%	Explore
gamma-delta T cell	18 studies	55% ± 16%	Explore
plasmacytoid dendritic cell	18 studies	36% ± 10%	Explore
connective tissue cell	18 studies	66% ± 20%	Explore
naive B cell	17 studies	35% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	57% ± 21%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	38% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	62% ± 13%	Explore
ciliated cell	16 studies	54% ± 19%	Explore
mucosal invariant T cell	15 studies	42% ± 16%	Explore
myeloid cell	15 studies	64% ± 21%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	48% ± 18%	Explore
myofibroblast cell	14 studies	66% ± 21%	Explore
capillary endothelial cell	13 studies	50% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	51% ± 18%	Explore
secretory cell	12 studies	67% ± 18%	Explore
endothelial cell of artery	12 studies	54% ± 16%	Explore
innate lymphoid cell	11 studies	59% ± 14%	Explore
plasmablast	11 studies	65% ± 21%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	51% ± 23%	Explore
astrocyte	11 studies	45% ± 28%	Explore
vein endothelial cell	11 studies	56% ± 15%	Explore
endothelial cell of vascular tree	11 studies	55% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	47% ± 16%	Explore
progenitor cell	10 studies	81% ± 15%	Explore
abnormal cell	10 studies	66% ± 26%	Explore
mesothelial cell	10 studies	71% ± 19%	Explore
type I pneumocyte	9 studies	48% ± 18%	Explore
type II pneumocyte	9 studies	59% ± 23%	Explore
neutrophil	9 studies	55% ± 21%	Explore
platelet	9 studies	32% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	9 studies	60% ± 26%	Explore
leukocyte	9 studies	51% ± 21%	Explore
goblet cell	9 studies	56% ± 12%	Explore
microglial cell	9 studies	55% ± 25%	Explore
club cell	8 studies	66% ± 19%	Explore
T follicular helper cell	8 studies	50% ± 11%	Explore
brush cell	8 studies	52% ± 21%	Explore
ionocyte	7 studies	69% ± 16%	Explore
mononuclear phagocyte	7 studies	58% ± 22%	Explore
epithelial cell of proximal tubule	7 studies	73% ± 16%	Explore
neuron	7 studies	57% ± 23%	Explore
enterocyte	7 studies	74% ± 18%	Explore
transit amplifying cell	7 studies	56% ± 31%	Explore
glutamatergic neuron	7 studies	28% ± 13%	Explore
retinal rod cell	7 studies	61% ± 24%	Explore
hematopoietic stem cell	7 studies	71% ± 20%	Explore
alveolar macrophage	6 studies	53% ± 18%	Explore
hematopoietic precursor cell	6 studies	68% ± 22%	Explore
respiratory goblet cell	6 studies	64% ± 20%	Explore
kidney loop of Henle epithelial cell	6 studies	67% ± 14%	Explore
renal alpha-intercalated cell	6 studies	82% ± 7%	Explore
megakaryocyte	6 studies	72% ± 14%	Explore
erythroblast	6 studies	56% ± 25%	Explore
amacrine cell	6 studies	68% ± 22%	Explore
retinal ganglion cell	6 studies	78% ± 26%	Explore
retinal cone cell	6 studies	73% ± 25%	Explore
erythrocyte	6 studies	51% ± 25%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	56% ± 23%	Explore
CD4-positive helper T cell	5 studies	38% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	49% ± 12%	Explore
exhausted T cell	5 studies	66% ± 16%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	81% ± 12%	Explore
enteroendocrine cell	5 studies	66% ± 25%	Explore
precursor B cell	5 studies	52% ± 19%	Explore
neuroendocrine cell	5 studies	70% ± 11%	Explore
T-helper 17 cell	5 studies	63% ± 23%	Explore
group 3 innate lymphoid cell	5 studies	76% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	75% ± 21%	Explore
intermediate monocyte	5 studies	80% ± 10%	Explore
granulocyte	5 studies	61% ± 21%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	62% ± 24%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	43% ± 21%	Explore
deuterosomal cell	4 studies	62% ± 19%	Explore
duct epithelial cell	4 studies	73% ± 9%	Explore
precursor cell	4 studies	72% ± 32%	Explore
squamous epithelial cell	4 studies	54% ± 19%	Explore
pancreatic A cell	4 studies	78% ± 12%	Explore
type B pancreatic cell	4 studies	67% ± 20%	Explore
glomerular endothelial cell	4 studies	52% ± 16%	Explore
podocyte	4 studies	70% ± 18%	Explore
intestinal crypt stem cell	4 studies	81% ± 6%	Explore
OFF-bipolar cell	4 studies	79% ± 19%	Explore
ON-bipolar cell	4 studies	76% ± 19%	Explore
pro-B cell	4 studies	43% ± 10%	Explore
immature B cell	4 studies	52% ± 12%	Explore
retina horizontal cell	4 studies	84% ± 9%	Explore
retinal pigment epithelial cell	4 studies	43% ± 26%	Explore
adventitial cell	4 studies	61% ± 9%	Explore
mucus secreting cell	4 studies	48% ± 13%	Explore
Mueller cell	4 studies	69% ± 16%	Explore
acinar cell	4 studies	39% ± 22%	Explore
muscle cell	4 studies	47% ± 15%	Explore
germinal center B cell	4 studies	58% ± 15%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	68% ± 12%	Explore
luminal cell of prostate epithelium	4 studies	31% ± 11%	Explore
IgG plasma cell	4 studies	28% ± 15%	Explore
GABAergic neuron	4 studies	27% ± 9%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	81% ± 25%	Explore
glial cell	4 studies	48% ± 20%	Explore
hepatocyte	4 studies	51% ± 20%	Explore
T-helper 1 cell	4 studies	67% ± 18%	Explore
hillock cell	3 studies	67% ± 36%	Explore
pancreatic D cell	3 studies	69% ± 22%	Explore
monocyte-derived dendritic cell	3 studies	68% ± 26%	Explore
kidney connecting tubule epithelial cell	3 studies	78% ± 13%	Explore
renal beta-intercalated cell	3 studies	92% ± 4%	Explore
neural crest cell	3 studies	76% ± 17%	Explore
retinal bipolar neuron	3 studies	73% ± 26%	Explore
GABAergic amacrine cell	3 studies	74% ± 14%	Explore
glycinergic amacrine cell	3 studies	71% ± 19%	Explore
renal principal cell	3 studies	74% ± 13%	Explore
thymocyte	3 studies	50% ± 22%	Explore
extravillous trophoblast	3 studies	93% ± 3%	Explore
placental villous trophoblast	3 studies	93% ± 5%	Explore
lymphocyte	3 studies	70% ± 12%	Explore
serous secreting cell	3 studies	57% ± 6%	Explore
tissue-resident macrophage	3 studies	54% ± 27%	Explore
intraepithelial lymphocyte	3 studies	70% ± 4%	Explore
rod bipolar cell	3 studies	78% ± 12%	Explore
cardiac muscle cell	3 studies	36% ± 14%	Explore
endothelial cell of sinusoid	3 studies	29% ± 7%	Explore
myoepithelial cell	3 studies	77% ± 2%	Explore
inflammatory macrophage	3 studies	49% ± 16%	Explore
IgM plasma cell	3 studies	37% ± 10%	Explore
pancreatic ductal cell	3 studies	83% ± 6%	Explore
keratinocyte	3 studies	68% ± 6%	Explore
melanocyte	3 studies	59% ± 19%	Explore
interneuron	3 studies	23% ± 7%	Explore
IgA plasma cell	3 studies	33% ± 15%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	48% ± 21%	Explore
double negative thymocyte	3 studies	66% ± 11%	Explore
progenitor cell of mammary luminal epithelium	3 studies	71% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	53% ± 14%	Explore
lung	18 studies	59% ± 16%	Explore
intestine	14 studies	50% ± 24%	Explore
brain	12 studies	32% ± 15%	Explore
eye	10 studies	60% ± 24%	Explore
kidney	9 studies	64% ± 17%	Explore
lymph node	7 studies	54% ± 20%	Explore
liver	7 studies	43% ± 14%	Explore
bone marrow	6 studies	47% ± 17%	Explore
pancreas	5 studies	62% ± 24%	Explore
uterus	5 studies	60% ± 24%	Explore
placenta	4 studies	76% ± 26%	Explore
prostate	4 studies	52% ± 16%	Explore
breast	4 studies	63% ± 7%	Explore
ovary	3 studies	34% ± 14%	Explore
heart	3 studies	33% ± 13%	Explore
adipose	3 studies	30% ± 16%	Explore
adrenal gland	3 studies	58% ± 7%	Explore
esophagus	3 studies	62% ± 25%	Explore
skin	3 studies	57% ± 9%	Explore
thymus	3 studies	61% ± 24%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	28151.73	89 / 89	100%	1036.90	900 / 901
uterus	100%	12893.03	170 / 170	100%	881.07	458 / 459
intestine	100%	20091.13	966 / 966	100%	776.44	525 / 527
skin	100%	29666.36	1808 / 1809	100%	755.07	470 / 472
ovary	99%	13590.38	179 / 180	100%	894.57	430 / 430
esophagus	100%	24321.43	1444 / 1445	99%	564.79	182 / 183
brain	100%	23653.50	2629 / 2642	100%	596.67	704 / 705
liver	100%	15262.83	225 / 226	100%	415.96	404 / 406
stomach	100%	13645.41	359 / 359	99%	620.16	283 / 286
lung	100%	17009.12	576 / 578	99%	865.63	1146 / 1155
thymus	100%	15526.34	652 / 653	99%	372.21	599 / 605
breast	100%	14982.60	459 / 459	99%	564.73	1102 / 1118
prostate	100%	15108.68	245 / 245	98%	390.58	494 / 502
bladder	100%	19824.81	21 / 21	98%	836.52	494 / 504
adrenal gland	100%	29728.86	258 / 258	97%	634.62	223 / 230
pancreas	91%	6799.62	297 / 328	98%	567.16	175 / 178
eye	0%	0	0 / 0	100%	539.92	80 / 80
lymph node	0%	0	0 / 0	100%	918.20	29 / 29
muscle	100%	38051.71	803 / 803	0%	0	0 / 0
spleen	100%	15375.61	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	973.84	45 / 45
ureter	0%	0	0 / 0	100%	273.77	1 / 1
adipose	100%	16477.98	1203 / 1204	0%	0	0 / 0
blood vessel	100%	16747.61	1331 / 1335	0%	0	0 / 0
peripheral blood	99%	34810.55	921 / 929	0%	0	0 / 0
heart	98%	27387.85	843 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0046166	Biological process	glyceraldehyde-3-phosphate biosynthetic process
GO_0061621	Biological process	canonical glycolysis
GO_0019242	Biological process	methylglyoxal biosynthetic process
GO_0006094	Biological process	gluconeogenesis
GO_0006096	Biological process	glycolytic process
GO_0019563	Biological process	glycerol catabolic process
GO_0005615	Cellular component	extracellular space
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005634	Cellular component	nucleus
GO_0042803	Molecular function	protein homodimerization activity
GO_0008929	Molecular function	methylglyoxal synthase activity
GO_0005515	Molecular function	protein binding
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0004807	Molecular function	triose-phosphate isomerase activity

IV. Literature review

[source]

Gene name	TPI1
Protein name	Triosephosphate isomerase (EC 5.3.1.1) Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase)
Synonyms	TPI
Description	FUNCTION: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. .; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. . FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. .; FUNCTION: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. . FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. .; FUNCTION: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. . FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. .; FUNCTION: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. .
Accessions	ENST00000493987.5 ENST00000462761.5 ENST00000495834.1 ENST00000396705.10 [P60174-1] U3KQF3 U3KPZ0 ENST00000613953.4 [P60174-3] ENST00000488464.6 [P60174-4] P60174 ENST00000535434.5 [P60174-4] U3KPS5 ENST00000229270.8 [P60174-3]

TPI1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review