TMEM59 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	42 studies	58% ± 21%	Explore
endothelial cell	41 studies	51% ± 20%	Explore
B cell	39 studies	34% ± 13%	Explore
macrophage	39 studies	41% ± 16%	Explore
natural killer cell	38 studies	44% ± 11%	Explore
CD8-positive, alpha-beta T cell	35 studies	40% ± 12%	Explore
pericyte	34 studies	54% ± 19%	Explore
T cell	32 studies	37% ± 12%	Explore
CD4-positive, alpha-beta T cell	31 studies	39% ± 10%	Explore
smooth muscle cell	28 studies	47% ± 17%	Explore
regulatory T cell	27 studies	43% ± 12%	Explore
conventional dendritic cell	26 studies	41% ± 15%	Explore
classical monocyte	25 studies	39% ± 14%	Explore
plasma cell	24 studies	68% ± 18%	Explore
endothelial cell of lymphatic vessel	24 studies	58% ± 18%	Explore
non-classical monocyte	23 studies	49% ± 14%	Explore
plasmacytoid dendritic cell	23 studies	53% ± 15%	Explore
epithelial cell	22 studies	63% ± 20%	Explore
basal cell	21 studies	64% ± 19%	Explore
ciliated cell	20 studies	73% ± 24%	Explore
mature NK T cell	20 studies	42% ± 13%	Explore
monocyte	19 studies	39% ± 11%	Explore
memory B cell	19 studies	29% ± 8%	Explore
connective tissue cell	19 studies	57% ± 16%	Explore
dendritic cell	18 studies	40% ± 23%	Explore
mast cell	18 studies	35% ± 12%	Explore
naive B cell	18 studies	29% ± 7%	Explore
gamma-delta T cell	17 studies	43% ± 11%	Explore
capillary endothelial cell	16 studies	43% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	38% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	47% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	36% ± 9%	Explore
oligodendrocyte	15 studies	36% ± 16%	Explore
astrocyte	14 studies	35% ± 18%	Explore
myofibroblast cell	14 studies	58% ± 15%	Explore
endothelial cell of artery	13 studies	51% ± 13%	Explore
vein endothelial cell	13 studies	48% ± 15%	Explore
mucosal invariant T cell	13 studies	38% ± 11%	Explore
plasmablast	12 studies	58% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	42% ± 13%	Explore
secretory cell	12 studies	70% ± 13%	Explore
endothelial cell of vascular tree	12 studies	54% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	39% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	42% ± 7%	Explore
goblet cell	11 studies	59% ± 20%	Explore
mesothelial cell	11 studies	58% ± 19%	Explore
myeloid cell	11 studies	41% ± 16%	Explore
type I pneumocyte	10 studies	56% ± 20%	Explore
type II pneumocyte	10 studies	48% ± 21%	Explore
club cell	10 studies	58% ± 27%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	43% ± 14%	Explore
progenitor cell	10 studies	51% ± 18%	Explore
innate lymphoid cell	9 studies	39% ± 10%	Explore
leukocyte	9 studies	36% ± 8%	Explore
abnormal cell	9 studies	49% ± 18%	Explore
IgG plasma cell	9 studies	56% ± 21%	Explore
neuron	8 studies	49% ± 20%	Explore
IgA plasma cell	8 studies	58% ± 22%	Explore
microglial cell	8 studies	33% ± 13%	Explore
erythrocyte	8 studies	32% ± 18%	Explore
oligodendrocyte precursor cell	8 studies	37% ± 15%	Explore
ionocyte	7 studies	70% ± 17%	Explore
neutrophil	7 studies	23% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	44% ± 10%	Explore
GABAergic neuron	7 studies	31% ± 14%	Explore
epithelial cell of proximal tubule	7 studies	46% ± 10%	Explore
enterocyte	7 studies	57% ± 15%	Explore
hematopoietic stem cell	7 studies	40% ± 20%	Explore
brush cell	7 studies	50% ± 20%	Explore
T follicular helper cell	7 studies	42% ± 6%	Explore
alveolar macrophage	6 studies	56% ± 18%	Explore
CD4-positive helper T cell	6 studies	32% ± 10%	Explore
respiratory goblet cell	6 studies	67% ± 17%	Explore
platelet	6 studies	21% ± 4%	Explore
mononuclear phagocyte	6 studies	47% ± 18%	Explore
kidney loop of Henle epithelial cell	6 studies	61% ± 21%	Explore
renal alpha-intercalated cell	6 studies	80% ± 9%	Explore
glutamatergic neuron	6 studies	40% ± 20%	Explore
amacrine cell	6 studies	37% ± 18%	Explore
retinal rod cell	6 studies	37% ± 18%	Explore
glial cell	6 studies	46% ± 21%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	46% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	41% ± 15%	Explore
duct epithelial cell	5 studies	70% ± 26%	Explore
exhausted T cell	5 studies	52% ± 10%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	74% ± 11%	Explore
enteroendocrine cell	5 studies	58% ± 21%	Explore
intestinal crypt stem cell	5 studies	53% ± 20%	Explore
transit amplifying cell	5 studies	50% ± 16%	Explore
retinal ganglion cell	5 studies	55% ± 28%	Explore
retinal cone cell	5 studies	50% ± 22%	Explore
erythroblast	5 studies	36% ± 23%	Explore
precursor B cell	5 studies	35% ± 13%	Explore
pro-B cell	5 studies	31% ± 8%	Explore
neuroendocrine cell	5 studies	76% ± 27%	Explore
immature B cell	5 studies	35% ± 16%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	54% ± 14%	Explore
granulocyte	5 studies	41% ± 14%	Explore
hematopoietic precursor cell	4 studies	53% ± 21%	Explore
deuterosomal cell	4 studies	56% ± 12%	Explore
squamous epithelial cell	4 studies	57% ± 25%	Explore
pancreatic A cell	4 studies	91% ± 4%	Explore
type B pancreatic cell	4 studies	88% ± 8%	Explore
glomerular endothelial cell	4 studies	62% ± 9%	Explore
podocyte	4 studies	78% ± 5%	Explore
OFF-bipolar cell	4 studies	33% ± 11%	Explore
ON-bipolar cell	4 studies	37% ± 12%	Explore
lymphocyte	4 studies	46% ± 17%	Explore
retina horizontal cell	4 studies	53% ± 13%	Explore
retinal pigment epithelial cell	4 studies	59% ± 24%	Explore
adventitial cell	4 studies	68% ± 13%	Explore
mucus secreting cell	4 studies	70% ± 23%	Explore
Mueller cell	4 studies	59% ± 20%	Explore
acinar cell	4 studies	47% ± 23%	Explore
muscle cell	4 studies	37% ± 23%	Explore
intermediate monocyte	4 studies	49% ± 23%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	83% ± 9%	Explore
luminal cell of prostate epithelium	4 studies	66% ± 23%	Explore
IgM plasma cell	4 studies	44% ± 18%	Explore
hepatocyte	4 studies	48% ± 24%	Explore
group 3 innate lymphoid cell	4 studies	50% ± 8%	Explore
melanocyte	4 studies	55% ± 18%	Explore
T-helper 17 cell	4 studies	39% ± 9%	Explore
interneuron	4 studies	36% ± 16%	Explore
adipocyte	4 studies	33% ± 24%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	43% ± 16%	Explore
hillock cell	3 studies	36% ± 14%	Explore
pancreatic D cell	3 studies	93% ± 4%	Explore
kidney connecting tubule epithelial cell	3 studies	88% ± 5%	Explore
renal beta-intercalated cell	3 studies	86% ± 10%	Explore
neural crest cell	3 studies	35% ± 8%	Explore
retinal bipolar neuron	3 studies	53% ± 17%	Explore
renal principal cell	3 studies	83% ± 4%	Explore
extravillous trophoblast	3 studies	80% ± 2%	Explore
placental villous trophoblast	3 studies	73% ± 21%	Explore
Schwann cell	3 studies	53% ± 18%	Explore
serous secreting cell	3 studies	69% ± 10%	Explore
tissue-resident macrophage	3 studies	35% ± 15%	Explore
intraepithelial lymphocyte	3 studies	47% ± 11%	Explore
rod bipolar cell	3 studies	47% ± 11%	Explore
cardiac muscle cell	3 studies	19% ± 1%	Explore
endothelial cell of sinusoid	3 studies	38% ± 7%	Explore
myoepithelial cell	3 studies	63% ± 6%	Explore
inflammatory macrophage	3 studies	27% ± 7%	Explore
pancreatic ductal cell	3 studies	86% ± 6%	Explore
keratinocyte	3 studies	53% ± 7%	Explore
T-helper 1 cell	3 studies	49% ± 3%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	43% ± 14%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	38% ± 16%	Explore
double negative thymocyte	3 studies	58% ± 4%	Explore
progenitor cell of mammary luminal epithelium	3 studies	63% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	19 studies	54% ± 18%	Explore
peripheral blood	18 studies	42% ± 12%	Explore
brain	16 studies	33% ± 14%	Explore
intestine	12 studies	51% ± 17%	Explore
eye	10 studies	41% ± 18%	Explore
kidney	9 studies	51% ± 11%	Explore
liver	6 studies	44% ± 18%	Explore
pancreas	5 studies	71% ± 26%	Explore
placenta	5 studies	50% ± 25%	Explore
bone marrow	5 studies	27% ± 8%	Explore
uterus	5 studies	60% ± 21%	Explore
prostate	5 studies	48% ± 19%	Explore
lymph node	5 studies	45% ± 12%	Explore
skin	4 studies	38% ± 19%	Explore
adipose	4 studies	30% ± 10%	Explore
breast	4 studies	60% ± 7%	Explore
heart	3 studies	26% ± 5%	Explore
adrenal gland	3 studies	44% ± 5%	Explore
esophagus	3 studies	55% ± 25%	Explore
thymus	3 studies	51% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	13907.59	459 / 459	100%	129.40	1118 / 1118
esophagus	100%	11031.87	1445 / 1445	100%	79.25	183 / 183
liver	100%	8103.60	226 / 226	100%	86.37	406 / 406
lung	100%	13045.31	578 / 578	100%	102.18	1155 / 1155
ovary	100%	11119.36	180 / 180	100%	107.27	430 / 430
pancreas	100%	8770.91	328 / 328	100%	122.23	178 / 178
prostate	100%	11672.50	245 / 245	100%	168.51	502 / 502
stomach	100%	12102.09	359 / 359	100%	91.02	286 / 286
uterus	100%	11891.91	170 / 170	100%	98.45	459 / 459
brain	100%	9264.12	2639 / 2642	100%	83.35	705 / 705
thymus	100%	14604.52	653 / 653	100%	141.42	603 / 605
kidney	100%	13099.85	89 / 89	100%	100.69	898 / 901
intestine	100%	13777.12	966 / 966	100%	98.76	525 / 527
bladder	100%	11477.14	21 / 21	100%	98.85	502 / 504
skin	100%	11448.53	1809 / 1809	99%	92.55	467 / 472
adrenal gland	100%	15571.67	258 / 258	99%	111.82	227 / 230
adipose	100%	12737.02	1204 / 1204	0%	0	0 / 0
blood vessel	100%	14611.36	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	46.04	29 / 29
muscle	100%	7304.72	803 / 803	0%	0	0 / 0
spleen	100%	9456.17	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	80.13	45 / 45
ureter	0%	0	0 / 0	100%	27.90	1 / 1
heart	98%	9225.66	846 / 861	0%	0	0 / 0
peripheral blood	96%	7857.76	894 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	90%	49.03	72 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1903077	Biological process	negative regulation of protein localization to plasma membrane
GO_0006914	Biological process	autophagy
GO_0010508	Biological process	positive regulation of autophagy
GO_0006486	Biological process	protein glycosylation
GO_0000138	Cellular component	Golgi trans cisterna
GO_0000139	Cellular component	Golgi membrane
GO_0000137	Cellular component	Golgi cis cisterna
GO_0005764	Cellular component	lysosome
GO_0070062	Cellular component	extracellular exosome
GO_0031902	Cellular component	late endosome membrane
GO_0005886	Cellular component	plasma membrane
GO_0005765	Cellular component	lysosomal membrane
GO_0005770	Cellular component	late endosome
GO_0005797	Cellular component	Golgi medial cisterna
GO_0004175	Molecular function	endopeptidase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TMEM59
Protein name	Transmembrane protein 59 Transmembrane protein 59 (Liver membrane-bound protein)
Synonyms	hCG_33694 HSPC001 C1orf8 UNQ169/PRO195
Description	FUNCTION: Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy . Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP . Inhibits APP transport to the cell surface and further shedding . .
Accessions	Q5T703 Q5T6Z8 ENST00000371341.5 ENST00000420738.5 ENST00000371337.3 ENST00000234831.10 ENST00000371344.5 Q5T704 ENST00000371348.5 Q5T706 ENST00000452421.5 Q6P5R1 Q9BXS4 ENST00000440019.5

TMEM59 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review