SUMO1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016925Biological processprotein sumoylation
GO_0006281Biological processDNA repair
GO_0034605Biological processcellular response to heat
GO_0086004Biological processregulation of cardiac muscle cell contraction
GO_0010621Biological processnegative regulation of transcription by transcription factor localization
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0032880Biological processregulation of protein localization
GO_0042308Biological processnegative regulation of protein import into nucleus
GO_0071276Biological processcellular response to cadmium ion
GO_1903169Biological processregulation of calcium ion transmembrane transport
GO_0030578Biological processPML body organization
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0031334Biological processpositive regulation of protein-containing complex assembly
GO_1902260Biological processnegative regulation of delayed rectifier potassium channel activity
GO_0060021Biological processroof of mouth development
GO_0050821Biological processprotein stabilization
GO_0045759Biological processnegative regulation of action potential
GO_0043392Biological processnegative regulation of DNA binding
GO_0090204Biological processprotein localization to nuclear pore
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005730Cellular componentnucleolus
GO_0005643Cellular componentnuclear pore
GO_0005886Cellular componentplasma membrane
GO_0097165Cellular componentnuclear stress granule
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0016605Cellular componentPML body
GO_0031965Cellular componentnuclear membrane
GO_0001741Cellular componentXY body
GO_0008076Cellular componentvoltage-gated potassium channel complex
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0019899Molecular functionenzyme binding
GO_0044388Molecular functionsmall protein activating enzyme binding
GO_0031386Molecular functionprotein tag activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0015459Molecular functionpotassium channel regulator activity
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_1990381Molecular functionubiquitin-specific protease binding
GO_0044389Molecular functionubiquitin-like protein ligase binding

IV. Literature review

[source]
Gene nameSUMO1
Protein nameSmall ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1)
Small ubiquitin like modifier 1
Small ubiquitin-related modifier 1
SynonymsOK/SW-cl.43
SMT3H3
SMT3C
UBL1
hCG_1776791
DescriptionFUNCTION: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 . Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 . .

AccessionsENST00000409205.5
ENST00000409627.6
ENST00000409368.5
ENST00000409498.6
B8ZZN6
P63165
ENST00000392245.5 [P63165-1]
ENST00000392246.7 [P63165-1]
B8ZZJ0
B9A032
B8ZZ67
F8WBI1
ENST00000392244.7 [P63165-2]
ENST00000409181.1
ENST00000409712.5