SNRPE | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	33 studies	31% ± 16%	Explore
natural killer cell	33 studies	28% ± 11%	Explore
fibroblast	32 studies	38% ± 18%	Explore
CD8-positive, alpha-beta T cell	31 studies	29% ± 14%	Explore
CD4-positive, alpha-beta T cell	28 studies	31% ± 16%	Explore
T cell	27 studies	32% ± 16%	Explore
endothelial cell	26 studies	41% ± 17%	Explore
conventional dendritic cell	24 studies	39% ± 20%	Explore
smooth muscle cell	23 studies	36% ± 18%	Explore
pericyte	22 studies	36% ± 17%	Explore
regulatory T cell	20 studies	28% ± 11%	Explore
basal cell	19 studies	43% ± 17%	Explore
classical monocyte	19 studies	27% ± 13%	Explore
epithelial cell	19 studies	50% ± 21%	Explore
macrophage	18 studies	30% ± 15%	Explore
memory B cell	17 studies	26% ± 11%	Explore
plasmacytoid dendritic cell	17 studies	33% ± 12%	Explore
endothelial cell of lymphatic vessel	16 studies	39% ± 15%	Explore
naive B cell	16 studies	25% ± 8%	Explore
gamma-delta T cell	16 studies	29% ± 17%	Explore
ciliated cell	15 studies	38% ± 20%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	25% ± 7%	Explore
connective tissue cell	15 studies	52% ± 19%	Explore
mast cell	14 studies	30% ± 14%	Explore
non-classical monocyte	14 studies	28% ± 12%	Explore
mature NK T cell	14 studies	25% ± 6%	Explore
monocyte	14 studies	35% ± 12%	Explore
plasma cell	13 studies	34% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	28% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	24% ± 6%	Explore
myofibroblast cell	13 studies	43% ± 22%	Explore
dendritic cell	13 studies	36% ± 25%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	27% ± 7%	Explore
capillary endothelial cell	11 studies	27% ± 11%	Explore
vein endothelial cell	11 studies	37% ± 17%	Explore
endothelial cell of vascular tree	11 studies	38% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	27% ± 10%	Explore
endothelial cell of artery	10 studies	30% ± 12%	Explore
mucosal invariant T cell	10 studies	21% ± 4%	Explore
myeloid cell	10 studies	30% ± 15%	Explore
plasmablast	9 studies	47% ± 22%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	26% ± 7%	Explore
secretory cell	9 studies	39% ± 17%	Explore
progenitor cell	9 studies	66% ± 17%	Explore
innate lymphoid cell	9 studies	33% ± 16%	Explore
abnormal cell	9 studies	48% ± 20%	Explore
leukocyte	8 studies	32% ± 18%	Explore
goblet cell	8 studies	36% ± 16%	Explore
club cell	7 studies	33% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	35% ± 15%	Explore
epithelial cell of proximal tubule	7 studies	39% ± 18%	Explore
mesothelial cell	7 studies	63% ± 23%	Explore
T follicular helper cell	7 studies	23% ± 3%	Explore
hematopoietic precursor cell	6 studies	59% ± 28%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	27% ± 8%	Explore
kidney loop of Henle epithelial cell	6 studies	32% ± 6%	Explore
renal alpha-intercalated cell	6 studies	53% ± 16%	Explore
erythroblast	6 studies	56% ± 30%	Explore
hematopoietic stem cell	6 studies	53% ± 17%	Explore
precursor B cell	6 studies	44% ± 22%	Explore
neuron	6 studies	46% ± 20%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	27% ± 12%	Explore
type I pneumocyte	5 studies	33% ± 16%	Explore
ionocyte	5 studies	32% ± 7%	Explore
mononuclear phagocyte	5 studies	37% ± 18%	Explore
intestinal crypt stem cell	5 studies	49% ± 19%	Explore
transit amplifying cell	5 studies	41% ± 22%	Explore
pro-B cell	5 studies	45% ± 20%	Explore
type II pneumocyte	5 studies	42% ± 20%	Explore
erythrocyte	5 studies	47% ± 25%	Explore
glutamatergic neuron	5 studies	21% ± 5%	Explore
pancreatic A cell	4 studies	57% ± 17%	Explore
type B pancreatic cell	4 studies	49% ± 16%	Explore
exhausted T cell	4 studies	30% ± 9%	Explore
enterocyte	4 studies	35% ± 16%	Explore
enteroendocrine cell	4 studies	59% ± 17%	Explore
immature B cell	4 studies	42% ± 24%	Explore
adventitial cell	4 studies	23% ± 9%	Explore
germinal center B cell	4 studies	39% ± 10%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	30% ± 9%	Explore
intermediate monocyte	4 studies	40% ± 18%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	46% ± 7%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	69% ± 21%	Explore
T-helper 17 cell	4 studies	36% ± 18%	Explore
deuterosomal cell	3 studies	48% ± 2%	Explore
duct epithelial cell	3 studies	19% ± 2%	Explore
precursor cell	3 studies	60% ± 19%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	73% ± 23%	Explore
neural crest cell	3 studies	80% ± 15%	Explore
retinal ganglion cell	3 studies	53% ± 26%	Explore
extravillous trophoblast	3 studies	53% ± 21%	Explore
placental villous trophoblast	3 studies	59% ± 22%	Explore
common myeloid progenitor	3 studies	43% ± 21%	Explore
lymphocyte	3 studies	45% ± 8%	Explore
neuroendocrine cell	3 studies	47% ± 3%	Explore
amacrine cell	3 studies	38% ± 14%	Explore
astrocyte	3 studies	25% ± 13%	Explore
retina horizontal cell	3 studies	31% ± 16%	Explore
serous secreting cell	3 studies	28% ± 6%	Explore
Mueller cell	3 studies	27% ± 6%	Explore
acinar cell	3 studies	40% ± 11%	Explore
muscle cell	3 studies	45% ± 19%	Explore
neutrophil	3 studies	24% ± 7%	Explore
CD4-positive helper T cell	3 studies	21% ± 3%	Explore
myoepithelial cell	3 studies	42% ± 14%	Explore
pancreatic ductal cell	3 studies	62% ± 7%	Explore
oligodendrocyte precursor cell	3 studies	42% ± 23%	Explore
granulocyte	3 studies	43% ± 14%	Explore
granulocyte monocyte progenitor cell	3 studies	67% ± 21%	Explore
glial cell	3 studies	43% ± 30%	Explore
hepatocyte	3 studies	49% ± 30%	Explore
group 3 innate lymphoid cell	3 studies	35% ± 20%	Explore
keratinocyte	3 studies	33% ± 7%	Explore
T-helper 1 cell	3 studies	33% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	23% ± 3%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	22% ± 5%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	23% ± 6%	Explore
double negative thymocyte	3 studies	45% ± 30%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	29% ± 6%	Explore
progenitor cell of mammary luminal epithelium	3 studies	38% ± 15%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	37% ± 17%	Explore
peripheral blood	16 studies	30% ± 11%	Explore
intestine	10 studies	38% ± 21%	Explore
kidney	8 studies	38% ± 16%	Explore
liver	7 studies	34% ± 22%	Explore
lymph node	6 studies	30% ± 18%	Explore
eye	6 studies	29% ± 13%	Explore
brain	6 studies	25% ± 4%	Explore
pancreas	5 studies	49% ± 17%	Explore
bone marrow	5 studies	35% ± 12%	Explore
uterus	5 studies	41% ± 18%	Explore
placenta	4 studies	46% ± 22%	Explore
prostate	4 studies	35% ± 10%	Explore
breast	4 studies	36% ± 8%	Explore
adrenal gland	3 studies	29% ± 9%	Explore
esophagus	3 studies	46% ± 30%	Explore
skin	3 studies	27% ± 4%	Explore
thymus	3 studies	61% ± 29%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1496.51	1445 / 1445	100%	80.86	183 / 183
liver	100%	1061.08	226 / 226	100%	82.52	406 / 406
ovary	100%	2659.02	180 / 180	100%	118.21	430 / 430
stomach	100%	1447.81	359 / 359	100%	80.12	286 / 286
uterus	100%	2117.45	170 / 170	100%	116.89	459 / 459
skin	100%	2446.27	1809 / 1809	100%	103.66	471 / 472
brain	100%	1148.78	2633 / 2642	100%	100.23	705 / 705
lung	100%	1433.49	576 / 578	100%	89.82	1155 / 1155
bladder	100%	1962.81	21 / 21	100%	91.15	502 / 504
breast	100%	2139.85	459 / 459	99%	130.00	1112 / 1118
intestine	100%	1678.67	966 / 966	99%	81.98	523 / 527
thymus	100%	1558.26	653 / 653	99%	71.82	600 / 605
pancreas	100%	1164.07	327 / 328	99%	67.32	177 / 178
prostate	100%	1675.33	245 / 245	99%	72.99	496 / 502
kidney	100%	1796.85	89 / 89	98%	50.93	881 / 901
adrenal gland	100%	1975.34	258 / 258	95%	50.28	218 / 230
adipose	100%	1907.31	1204 / 1204	0%	0	0 / 0
blood vessel	100%	1577.77	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	73.02	80 / 80
lymph node	0%	0	0 / 0	100%	171.69	29 / 29
spleen	100%	1757.46	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	80.74	45 / 45
ureter	0%	0	0 / 0	100%	108.77	1 / 1
muscle	99%	1165.55	798 / 803	0%	0	0 / 0
heart	97%	979.39	833 / 861	0%	0	0 / 0
peripheral blood	61%	1543.80	568 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000387	Biological process	spliceosomal snRNP assembly
GO_0036261	Biological process	7-methylguanosine cap hypermethylation
GO_1903241	Biological process	U2-type prespliceosome assembly
GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0000245	Biological process	spliceosomal complex assembly
GO_0046540	Cellular component	U4/U6 x U5 tri-snRNP complex
GO_0005686	Cellular component	U2 snRNP
GO_0005685	Cellular component	U1 snRNP
GO_0005681	Cellular component	spliceosomal complex
GO_0005654	Cellular component	nucleoplasm
GO_0071007	Cellular component	U2-type catalytic step 2 spliceosome
GO_0005697	Cellular component	telomerase holoenzyme complex
GO_0071005	Cellular component	U2-type precatalytic spliceosome
GO_0005683	Cellular component	U7 snRNP
GO_0034709	Cellular component	methylosome
GO_0034719	Cellular component	SMN-Sm protein complex
GO_0071011	Cellular component	precatalytic spliceosome
GO_0005829	Cellular component	cytosol
GO_0005684	Cellular component	U2-type spliceosomal complex
GO_0005682	Cellular component	U5 snRNP
GO_0005687	Cellular component	U4 snRNP
GO_0034715	Cellular component	pICln-Sm protein complex
GO_0071013	Cellular component	catalytic step 2 spliceosome
GO_0030532	Cellular component	small nuclear ribonucleoprotein complex
GO_0005689	Cellular component	U12-type spliceosomal complex
GO_0005634	Cellular component	nucleus
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SNRPE
Protein name	Small nuclear ribonucleoprotein E (snRNP-E) (Sm protein E) Small nuclear ribonucleoprotein E (snRNP-E) (Sm protein E) (Sm-E) (SmE)
Synonyms
Description	FUNCTION: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome . Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes . As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs . As part of the U7 snRNP it is involved in histone 3'-end processing . . FUNCTION: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing. .
Accessions	P62304 A6NHK2 ENST00000367208.1 ENST00000414487.7

SNRPE report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review