SNRPB | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	38 studies	41% ± 14%	Explore
natural killer cell	37 studies	48% ± 15%	Explore
CD8-positive, alpha-beta T cell	34 studies	44% ± 20%	Explore
endothelial cell	32 studies	42% ± 17%	Explore
CD4-positive, alpha-beta T cell	31 studies	41% ± 20%	Explore
fibroblast	30 studies	36% ± 12%	Explore
T cell	28 studies	45% ± 16%	Explore
conventional dendritic cell	27 studies	44% ± 15%	Explore
macrophage	26 studies	33% ± 12%	Explore
regulatory T cell	26 studies	41% ± 13%	Explore
smooth muscle cell	24 studies	37% ± 12%	Explore
pericyte	24 studies	41% ± 12%	Explore
non-classical monocyte	23 studies	44% ± 16%	Explore
classical monocyte	23 studies	34% ± 13%	Explore
memory B cell	20 studies	38% ± 11%	Explore
plasmacytoid dendritic cell	20 studies	43% ± 14%	Explore
epithelial cell	20 studies	46% ± 19%	Explore
basal cell	19 studies	44% ± 18%	Explore
dendritic cell	18 studies	41% ± 23%	Explore
mature NK T cell	18 studies	40% ± 12%	Explore
naive B cell	18 studies	37% ± 11%	Explore
monocyte	17 studies	36% ± 13%	Explore
endothelial cell of lymphatic vessel	17 studies	44% ± 14%	Explore
gamma-delta T cell	17 studies	44% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	45% ± 13%	Explore
mast cell	15 studies	35% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	40% ± 14%	Explore
connective tissue cell	15 studies	40% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	35% ± 10%	Explore
plasma cell	13 studies	38% ± 15%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	42% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	40% ± 14%	Explore
capillary endothelial cell	12 studies	36% ± 14%	Explore
myofibroblast cell	12 studies	39% ± 14%	Explore
mucosal invariant T cell	12 studies	38% ± 10%	Explore
myeloid cell	12 studies	41% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	38% ± 15%	Explore
secretory cell	11 studies	38% ± 16%	Explore
vein endothelial cell	11 studies	39% ± 16%	Explore
endothelial cell of vascular tree	11 studies	53% ± 18%	Explore
plasmablast	10 studies	55% ± 23%	Explore
abnormal cell	10 studies	44% ± 15%	Explore
endothelial cell of artery	10 studies	33% ± 11%	Explore
ciliated cell	10 studies	39% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	44% ± 16%	Explore
progenitor cell	9 studies	49% ± 15%	Explore
innate lymphoid cell	9 studies	47% ± 9%	Explore
type I pneumocyte	8 studies	32% ± 15%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	55% ± 18%	Explore
leukocyte	8 studies	43% ± 14%	Explore
goblet cell	8 studies	33% ± 15%	Explore
T follicular helper cell	8 studies	37% ± 6%	Explore
club cell	7 studies	32% ± 17%	Explore
mesothelial cell	7 studies	43% ± 17%	Explore
erythrocyte	7 studies	37% ± 26%	Explore
hematopoietic precursor cell	6 studies	51% ± 27%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	48% ± 12%	Explore
intestinal crypt stem cell	6 studies	33% ± 12%	Explore
transit amplifying cell	6 studies	43% ± 21%	Explore
precursor B cell	6 studies	46% ± 16%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	48% ± 19%	Explore
alveolar macrophage	5 studies	25% ± 4%	Explore
exhausted T cell	5 studies	52% ± 17%	Explore
mononuclear phagocyte	5 studies	46% ± 15%	Explore
kidney loop of Henle epithelial cell	5 studies	21% ± 4%	Explore
epithelial cell of proximal tubule	5 studies	24% ± 13%	Explore
enteroendocrine cell	5 studies	41% ± 16%	Explore
erythroblast	5 studies	51% ± 21%	Explore
hematopoietic stem cell	5 studies	52% ± 12%	Explore
pro-B cell	5 studies	45% ± 9%	Explore
type II pneumocyte	5 studies	36% ± 15%	Explore
granulocyte	5 studies	34% ± 9%	Explore
pancreatic A cell	4 studies	63% ± 15%	Explore
enterocyte	4 studies	26% ± 12%	Explore
brush cell	4 studies	28% ± 12%	Explore
immature B cell	4 studies	52% ± 17%	Explore
germinal center B cell	4 studies	46% ± 14%	Explore
intermediate monocyte	4 studies	46% ± 22%	Explore
CD4-positive helper T cell	4 studies	38% ± 15%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	54% ± 11%	Explore
group 3 innate lymphoid cell	4 studies	50% ± 14%	Explore
T-helper 17 cell	4 studies	53% ± 26%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	36% ± 6%	Explore
double negative thymocyte	4 studies	49% ± 18%	Explore
deuterosomal cell	3 studies	31% ± 5%	Explore
duct epithelial cell	3 studies	19% ± 3%	Explore
ionocyte	3 studies	27% ± 6%	Explore
precursor cell	3 studies	60% ± 12%	Explore
platelet	3 studies	20% ± 5%	Explore
type B pancreatic cell	3 studies	50% ± 10%	Explore
monocyte-derived dendritic cell	3 studies	47% ± 21%	Explore
glomerular endothelial cell	3 studies	22% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	54% ± 22%	Explore
neural crest cell	3 studies	66% ± 11%	Explore
extravillous trophoblast	3 studies	59% ± 16%	Explore
placental villous trophoblast	3 studies	68% ± 10%	Explore
common myeloid progenitor	3 studies	42% ± 21%	Explore
lymphocyte	3 studies	62% ± 8%	Explore
megakaryocyte	3 studies	30% ± 6%	Explore
neuroendocrine cell	3 studies	28% ± 0%	Explore
retina horizontal cell	3 studies	28% ± 13%	Explore
serous secreting cell	3 studies	21% ± 2%	Explore
intraepithelial lymphocyte	3 studies	46% ± 11%	Explore
muscle cell	3 studies	34% ± 17%	Explore
neutrophil	3 studies	19% ± 4%	Explore
myoepithelial cell	3 studies	46% ± 15%	Explore
neuron	3 studies	41% ± 16%	Explore
luminal cell of prostate epithelium	3 studies	22% ± 7%	Explore
glutamatergic neuron	3 studies	20% ± 2%	Explore
acinar cell	3 studies	32% ± 14%	Explore
pancreatic ductal cell	3 studies	69% ± 6%	Explore
oligodendrocyte precursor cell	3 studies	33% ± 10%	Explore
granulocyte monocyte progenitor cell	3 studies	57% ± 31%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	60% ± 22%	Explore
keratinocyte	3 studies	51% ± 10%	Explore
T-helper 1 cell	3 studies	55% ± 16%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	33% ± 7%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	31% ± 7%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	56% ± 12%	Explore
progenitor cell of mammary luminal epithelium	3 studies	44% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	17 studies	36% ± 13%	Explore
peripheral blood	17 studies	41% ± 13%	Explore
intestine	13 studies	30% ± 14%	Explore
kidney	8 studies	32% ± 12%	Explore
liver	6 studies	40% ± 21%	Explore
lymph node	6 studies	44% ± 17%	Explore
bone marrow	5 studies	31% ± 8%	Explore
uterus	5 studies	43% ± 18%	Explore
brain	5 studies	25% ± 6%	Explore
pancreas	4 studies	53% ± 14%	Explore
placenta	4 studies	47% ± 21%	Explore
prostate	4 studies	41% ± 15%	Explore
breast	4 studies	46% ± 11%	Explore
ovary	3 studies	28% ± 12%	Explore
eye	3 studies	30% ± 7%	Explore
adrenal gland	3 studies	36% ± 13%	Explore
esophagus	3 studies	43% ± 24%	Explore
thymus	3 studies	56% ± 31%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5687.95	1445 / 1445	100%	442.48	183 / 183
ovary	100%	4568.26	180 / 180	100%	479.46	430 / 430
uterus	100%	5436.86	170 / 170	100%	569.85	459 / 459
skin	100%	7423.19	1809 / 1809	100%	366.70	471 / 472
intestine	100%	5022.34	966 / 966	99%	529.36	524 / 527
thymus	100%	4246.99	652 / 653	100%	254.47	602 / 605
stomach	100%	3916.58	359 / 359	99%	476.59	284 / 286
prostate	100%	4712.09	245 / 245	99%	254.96	498 / 502
bladder	100%	4748.90	21 / 21	99%	544.70	499 / 504
adrenal gland	100%	5127.99	258 / 258	99%	217.03	227 / 230
kidney	100%	4352.62	89 / 89	99%	182.19	889 / 901
breast	100%	5697.81	459 / 459	99%	324.10	1102 / 1118
lung	100%	5546.13	577 / 578	99%	376.91	1138 / 1155
pancreas	99%	2185.54	324 / 328	98%	266.68	175 / 178
liver	100%	2502.75	225 / 226	97%	238.31	392 / 406
brain	93%	1969.21	2468 / 2642	97%	173.19	682 / 705
adipose	100%	5340.26	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	244.85	80 / 80
lymph node	0%	0	0 / 0	100%	634.20	29 / 29
spleen	100%	6802.73	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	545.14	45 / 45
ureter	0%	0	0 / 0	100%	302.75	1 / 1
blood vessel	100%	4708.18	1334 / 1335	0%	0	0 / 0
muscle	99%	3211.40	798 / 803	0%	0	0 / 0
peripheral blood	99%	6724.65	921 / 929	0%	0	0 / 0
heart	98%	2551.97	847 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000387	Biological process	spliceosomal snRNP assembly
GO_0036261	Biological process	7-methylguanosine cap hypermethylation
GO_1903241	Biological process	U2-type prespliceosome assembly
GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0006479	Biological process	protein methylation
GO_0008380	Biological process	RNA splicing
GO_0046540	Cellular component	U4/U6 x U5 tri-snRNP complex
GO_0005686	Cellular component	U2 snRNP
GO_0005685	Cellular component	U1 snRNP
GO_0005681	Cellular component	spliceosomal complex
GO_0005654	Cellular component	nucleoplasm
GO_0071007	Cellular component	U2-type catalytic step 2 spliceosome
GO_0005697	Cellular component	telomerase holoenzyme complex
GO_0071005	Cellular component	U2-type precatalytic spliceosome
GO_0005683	Cellular component	U7 snRNP
GO_0034709	Cellular component	methylosome
GO_0034719	Cellular component	SMN-Sm protein complex
GO_0071204	Cellular component	histone pre-mRNA 3'end processing complex
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005684	Cellular component	U2-type spliceosomal complex
GO_0005682	Cellular component	U5 snRNP
GO_0005687	Cellular component	U4 snRNP
GO_0071004	Cellular component	U2-type prespliceosome
GO_0071013	Cellular component	catalytic step 2 spliceosome
GO_0030532	Cellular component	small nuclear ribonucleoprotein complex
GO_0005689	Cellular component	U12-type spliceosomal complex
GO_0005634	Cellular component	nucleus
GO_1990447	Molecular function	U2 snRNP binding
GO_0070990	Molecular function	snRNP binding
GO_0071208	Molecular function	histone pre-mRNA DCP binding
GO_0003723	Molecular function	RNA binding
GO_0070034	Molecular function	telomerase RNA binding
GO_0005515	Molecular function	protein binding
GO_1990446	Molecular function	U1 snRNP binding

IV. Literature review

[source]

Gene name	SNRPB
Protein name	Small nuclear ribonucleoprotein polypeptides B and B1 Small nuclear ribonucleoprotein-associated proteins B and B' (snRNP-B) (Sm protein B/B') (Sm-B/B') (SmB/B') Small nuclear ribonucleoprotein-associated protein
Synonyms	SNRPB1 COD hCG_2039421
Description	FUNCTION: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome . Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes . As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs . As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing . .
Accessions	B4DVS0 ENST00000438552.6 [P14678-1] S4R3P3 Q66K91 ENST00000381342.7 [P14678-2] P14678 ENST00000474384.2 Q15182 Q9UIS4

SNRPB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review