SF3B6 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	35 studies	33% ± 10%	Explore
B cell	34 studies	32% ± 12%	Explore
fibroblast	33 studies	41% ± 14%	Explore
endothelial cell	31 studies	43% ± 17%	Explore
CD8-positive, alpha-beta T cell	30 studies	34% ± 14%	Explore
CD4-positive, alpha-beta T cell	28 studies	34% ± 13%	Explore
T cell	27 studies	34% ± 12%	Explore
macrophage	26 studies	29% ± 12%	Explore
conventional dendritic cell	25 studies	35% ± 16%	Explore
smooth muscle cell	24 studies	40% ± 13%	Explore
pericyte	24 studies	42% ± 14%	Explore
epithelial cell	22 studies	48% ± 21%	Explore
classical monocyte	22 studies	31% ± 13%	Explore
non-classical monocyte	21 studies	34% ± 15%	Explore
regulatory T cell	21 studies	38% ± 8%	Explore
basal cell	20 studies	46% ± 17%	Explore
plasmacytoid dendritic cell	19 studies	32% ± 12%	Explore
memory B cell	18 studies	29% ± 8%	Explore
connective tissue cell	18 studies	42% ± 17%	Explore
mast cell	17 studies	31% ± 13%	Explore
monocyte	17 studies	32% ± 10%	Explore
naive B cell	17 studies	26% ± 6%	Explore
gamma-delta T cell	17 studies	32% ± 15%	Explore
endothelial cell of lymphatic vessel	16 studies	38% ± 13%	Explore
ciliated cell	16 studies	51% ± 20%	Explore
mature NK T cell	15 studies	31% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	34% ± 9%	Explore
dendritic cell	14 studies	37% ± 25%	Explore
plasma cell	13 studies	40% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	29% ± 7%	Explore
myofibroblast cell	13 studies	46% ± 12%	Explore
capillary endothelial cell	12 studies	34% ± 11%	Explore
secretory cell	11 studies	42% ± 18%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	34% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	34% ± 10%	Explore
endothelial cell of artery	11 studies	39% ± 12%	Explore
vein endothelial cell	11 studies	40% ± 11%	Explore
endothelial cell of vascular tree	11 studies	40% ± 9%	Explore
myeloid cell	11 studies	31% ± 14%	Explore
plasmablast	10 studies	45% ± 22%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	31% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	36% ± 14%	Explore
abnormal cell	10 studies	43% ± 19%	Explore
mucosal invariant T cell	10 studies	31% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	33% ± 14%	Explore
progenitor cell	9 studies	52% ± 10%	Explore
goblet cell	9 studies	38% ± 18%	Explore
type I pneumocyte	8 studies	36% ± 17%	Explore
T follicular helper cell	8 studies	34% ± 6%	Explore
club cell	7 studies	42% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	40% ± 13%	Explore
leukocyte	7 studies	34% ± 8%	Explore
epithelial cell of proximal tubule	7 studies	39% ± 13%	Explore
enterocyte	7 studies	37% ± 14%	Explore
mesothelial cell	7 studies	55% ± 18%	Explore
neuron	7 studies	46% ± 23%	Explore
type II pneumocyte	6 studies	46% ± 19%	Explore
respiratory goblet cell	6 studies	29% ± 22%	Explore
kidney loop of Henle epithelial cell	6 studies	39% ± 5%	Explore
renal alpha-intercalated cell	6 studies	45% ± 11%	Explore
precursor B cell	6 studies	40% ± 15%	Explore
innate lymphoid cell	6 studies	30% ± 3%	Explore
erythrocyte	6 studies	40% ± 23%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	37% ± 16%	Explore
alveolar macrophage	5 studies	26% ± 8%	Explore
ionocyte	5 studies	34% ± 14%	Explore
mononuclear phagocyte	5 studies	36% ± 16%	Explore
intestinal crypt stem cell	5 studies	35% ± 13%	Explore
transit amplifying cell	5 studies	27% ± 12%	Explore
hematopoietic stem cell	5 studies	47% ± 8%	Explore
pro-B cell	5 studies	34% ± 9%	Explore
neutrophil	5 studies	20% ± 3%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	41% ± 14%	Explore
granulocyte	5 studies	31% ± 11%	Explore
hematopoietic precursor cell	4 studies	57% ± 27%	Explore
exhausted T cell	4 studies	47% ± 13%	Explore
glomerular endothelial cell	4 studies	34% ± 8%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	57% ± 13%	Explore
enteroendocrine cell	4 studies	53% ± 12%	Explore
erythroblast	4 studies	49% ± 25%	Explore
brush cell	4 studies	35% ± 20%	Explore
immature B cell	4 studies	43% ± 18%	Explore
adventitial cell	4 studies	27% ± 8%	Explore
CD4-positive helper T cell	4 studies	27% ± 10%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	60% ± 6%	Explore
T-helper 17 cell	4 studies	39% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	29% ± 8%	Explore
deuterosomal cell	3 studies	38% ± 4%	Explore
duct epithelial cell	3 studies	24% ± 4%	Explore
precursor cell	3 studies	57% ± 12%	Explore
pancreatic A cell	3 studies	56% ± 14%	Explore
type B pancreatic cell	3 studies	46% ± 21%	Explore
neural crest cell	3 studies	59% ± 4%	Explore
extravillous trophoblast	3 studies	68% ± 8%	Explore
placental villous trophoblast	3 studies	58% ± 13%	Explore
lymphocyte	3 studies	46% ± 13%	Explore
megakaryocyte	3 studies	26% ± 8%	Explore
neuroendocrine cell	3 studies	42% ± 10%	Explore
amacrine cell	3 studies	37% ± 14%	Explore
astrocyte	3 studies	34% ± 20%	Explore
retina horizontal cell	3 studies	30% ± 18%	Explore
retinal cone cell	3 studies	52% ± 20%	Explore
retinal rod cell	3 studies	36% ± 16%	Explore
serous secreting cell	3 studies	31% ± 2%	Explore
intraepithelial lymphocyte	3 studies	35% ± 16%	Explore
Mueller cell	3 studies	34% ± 10%	Explore
acinar cell	3 studies	30% ± 9%	Explore
muscle cell	3 studies	40% ± 19%	Explore
germinal center B cell	3 studies	47% ± 3%	Explore
intermediate monocyte	3 studies	46% ± 23%	Explore
myoepithelial cell	3 studies	52% ± 5%	Explore
luminal cell of prostate epithelium	3 studies	33% ± 10%	Explore
glutamatergic neuron	3 studies	23% ± 5%	Explore
oligodendrocyte precursor cell	3 studies	38% ± 14%	Explore
granulocyte monocyte progenitor cell	3 studies	43% ± 26%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	58% ± 26%	Explore
glial cell	3 studies	44% ± 23%	Explore
hepatocyte	3 studies	44% ± 33%	Explore
group 3 innate lymphoid cell	3 studies	41% ± 16%	Explore
keratinocyte	3 studies	54% ± 10%	Explore
T-helper 1 cell	3 studies	42% ± 10%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	28% ± 8%	Explore
double negative thymocyte	3 studies	52% ± 22%	Explore
progenitor cell of mammary luminal epithelium	3 studies	45% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	33% ± 12%	Explore
lung	17 studies	40% ± 16%	Explore
intestine	11 studies	35% ± 17%	Explore
kidney	9 studies	36% ± 10%	Explore
eye	7 studies	29% ± 14%	Explore
brain	6 studies	23% ± 5%	Explore
liver	6 studies	35% ± 24%	Explore
uterus	5 studies	43% ± 19%	Explore
lymph node	5 studies	39% ± 14%	Explore
pancreas	4 studies	44% ± 19%	Explore
placenta	4 studies	46% ± 19%	Explore
bone marrow	4 studies	31% ± 8%	Explore
prostate	4 studies	33% ± 12%	Explore
breast	4 studies	43% ± 4%	Explore
adrenal gland	3 studies	30% ± 5%	Explore
esophagus	3 studies	52% ± 26%	Explore
skin	3 studies	36% ± 12%	Explore
thymus	3 studies	60% ± 22%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2580.27	1445 / 1445	100%	193.30	183 / 183
lung	100%	1994.77	578 / 578	100%	208.03	1155 / 1155
ovary	100%	2192.38	180 / 180	100%	255.38	430 / 430
prostate	100%	2018.47	245 / 245	100%	175.09	502 / 502
skin	100%	2562.19	1809 / 1809	100%	190.21	472 / 472
stomach	100%	1689.14	359 / 359	100%	191.27	286 / 286
uterus	100%	2183.74	170 / 170	100%	264.67	459 / 459
brain	100%	1454.35	2639 / 2642	100%	160.79	705 / 705
thymus	100%	2292.17	653 / 653	100%	196.95	604 / 605
breast	100%	2462.20	459 / 459	100%	219.91	1116 / 1118
intestine	100%	2487.89	966 / 966	100%	199.84	526 / 527
bladder	100%	2179.29	21 / 21	100%	214.95	503 / 504
liver	100%	1404.08	225 / 226	100%	128.29	406 / 406
kidney	100%	2400.21	89 / 89	99%	126.84	895 / 901
adrenal gland	100%	2410.22	258 / 258	99%	125.43	228 / 230
pancreas	99%	1047.24	326 / 328	99%	160.00	177 / 178
adipose	100%	2282.86	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	162.22	80 / 80
lymph node	0%	0	0 / 0	100%	232.90	29 / 29
spleen	100%	1901.34	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	208.16	45 / 45
ureter	0%	0	0 / 0	100%	97.72	1 / 1
blood vessel	100%	2406.93	1334 / 1335	0%	0	0 / 0
muscle	100%	1306.68	799 / 803	0%	0	0 / 0
heart	99%	1399.11	851 / 861	0%	0	0 / 0
peripheral blood	82%	1661.16	766 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0001825	Biological process	blastocyst formation
GO_1903241	Biological process	U2-type prespliceosome assembly
GO_0005686	Cellular component	U2 snRNP
GO_0071011	Cellular component	precatalytic spliceosome
GO_0071013	Cellular component	catalytic step 2 spliceosome
GO_0005654	Cellular component	nucleoplasm
GO_0005681	Cellular component	spliceosomal complex
GO_0005689	Cellular component	U12-type spliceosomal complex
GO_0005684	Cellular component	U2-type spliceosomal complex
GO_0005634	Cellular component	nucleus
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding
GO_0003729	Molecular function	mRNA binding

IV. Literature review

[source]

Gene name	SF3B6
Protein name	Splicing factor 3B subunit 6 (Pre-mRNA branch site protein p14) (SF3b 14 kDa subunit) (SF3B14a) (Spliceosome-associated protein, 14-kDa) (Splicing factor 3b, subunit 6, 14kDa)
Synonyms	HT006 CGI-110 SF3B14A SF3B14 SAP14 HSPC175
Description	FUNCTION: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs . The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing . Within the 17S U2 SnRNP complex, SF3B6 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA . Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA . Within the 17S U2 SnRNP complex, SF3B6 directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing . SF3B6 stabilizes the intron branch site-U2 snRNA duplex, thereby promoting-binding of introns with poor sequence complementarity . Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs . .
Accessions	Q9Y3B4 ENST00000233468.5

SF3B6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review