SF3B1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_1903241Biological processU2-type prespliceosome assembly
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0008380Biological processRNA splicing
GO_0045945Biological processpositive regulation of transcription by RNA polymerase III
GO_0045943Biological processpositive regulation of transcription by RNA polymerase I
GO_0000245Biological processspliceosomal complex assembly
GO_0000375Biological processRNA splicing, via transesterification reactions
GO_0005686Cellular componentU2 snRNP
GO_0005730Cellular componentnucleolus
GO_0005681Cellular componentspliceosomal complex
GO_0110016Cellular componentB-WICH complex
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0071005Cellular componentU2-type precatalytic spliceosome
GO_0005684Cellular componentU2-type spliceosomal complex
GO_0034693Cellular componentU11/U12 snRNP
GO_0071004Cellular componentU2-type prespliceosome
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_0005689Cellular componentU12-type spliceosomal complex
GO_0005634Cellular componentnucleus
GO_0003729Molecular functionmRNA binding
GO_1990935Molecular functionsplicing factor binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSF3B1
Protein nameSplicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155)
Splicing factor 3b subunit 1
SF3B1 protein
SynonymsSAP155
DescriptionFUNCTION: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs . The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing . Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA . Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA . May also be involved in the assembly of the 'E' complex . Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs . Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). .

AccessionsENST00000414174.1
O75533
F8WC19
A0PJH5
ENST00000414963.2 [O75533-2]
Q32Q20
A0A494C1M2
ENST00000652738.1
B4DGZ4
Q7Z497
A0JLT9
ENST00000424674.1
H7C341
ENST00000409915.8 [O75533-2]
ENST00000487698.5
ENST00000335508.11 [O75533-1]
ENST00000652026.1