SERBP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	41 studies	51% ± 21%	Explore
B cell	39 studies	48% ± 14%	Explore
natural killer cell	39 studies	52% ± 16%	Explore
fibroblast	38 studies	47% ± 18%	Explore
T cell	34 studies	45% ± 18%	Explore
CD8-positive, alpha-beta T cell	34 studies	47% ± 19%	Explore
macrophage	33 studies	40% ± 13%	Explore
CD4-positive, alpha-beta T cell	32 studies	49% ± 19%	Explore
pericyte	31 studies	50% ± 19%	Explore
conventional dendritic cell	28 studies	56% ± 15%	Explore
smooth muscle cell	27 studies	50% ± 20%	Explore
regulatory T cell	26 studies	52% ± 14%	Explore
dendritic cell	23 studies	47% ± 22%	Explore
non-classical monocyte	23 studies	40% ± 14%	Explore
classical monocyte	23 studies	42% ± 12%	Explore
plasmacytoid dendritic cell	22 studies	55% ± 17%	Explore
basal cell	22 studies	57% ± 18%	Explore
epithelial cell	22 studies	55% ± 21%	Explore
endothelial cell of lymphatic vessel	20 studies	53% ± 17%	Explore
mature NK T cell	20 studies	43% ± 15%	Explore
memory B cell	20 studies	48% ± 10%	Explore
naive B cell	20 studies	43% ± 12%	Explore
mast cell	18 studies	43% ± 17%	Explore
monocyte	18 studies	40% ± 13%	Explore
gamma-delta T cell	18 studies	50% ± 16%	Explore
plasma cell	17 studies	42% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	46% ± 14%	Explore
ciliated cell	17 studies	50% ± 22%	Explore
connective tissue cell	17 studies	56% ± 18%	Explore
mucosal invariant T cell	16 studies	43% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	50% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	51% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	52% ± 13%	Explore
myofibroblast cell	14 studies	52% ± 20%	Explore
capillary endothelial cell	13 studies	41% ± 20%	Explore
endothelial cell of vascular tree	13 studies	56% ± 19%	Explore
plasmablast	12 studies	55% ± 24%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	49% ± 15%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	51% ± 14%	Explore
secretory cell	12 studies	53% ± 18%	Explore
endothelial cell of artery	12 studies	52% ± 16%	Explore
vein endothelial cell	12 studies	57% ± 18%	Explore
myeloid cell	12 studies	51% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	46% ± 15%	Explore
innate lymphoid cell	10 studies	49% ± 14%	Explore
progenitor cell	10 studies	62% ± 26%	Explore
abnormal cell	10 studies	48% ± 16%	Explore
goblet cell	10 studies	41% ± 18%	Explore
type II pneumocyte	9 studies	41% ± 21%	Explore
club cell	9 studies	43% ± 18%	Explore
leukocyte	9 studies	46% ± 19%	Explore
type I pneumocyte	8 studies	38% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	55% ± 19%	Explore
neuron	8 studies	51% ± 21%	Explore
mesothelial cell	8 studies	62% ± 28%	Explore
T follicular helper cell	8 studies	44% ± 6%	Explore
microglial cell	8 studies	27% ± 13%	Explore
astrocyte	8 studies	28% ± 12%	Explore
alveolar macrophage	7 studies	35% ± 13%	Explore
epithelial cell of proximal tubule	7 studies	34% ± 15%	Explore
hematopoietic stem cell	7 studies	73% ± 9%	Explore
precursor B cell	7 studies	64% ± 17%	Explore
brush cell	7 studies	44% ± 28%	Explore
immature B cell	7 studies	56% ± 18%	Explore
erythrocyte	7 studies	43% ± 29%	Explore
oligodendrocyte precursor cell	7 studies	34% ± 18%	Explore
respiratory goblet cell	6 studies	41% ± 18%	Explore
platelet	6 studies	22% ± 5%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	57% ± 15%	Explore
mononuclear phagocyte	6 studies	47% ± 20%	Explore
renal alpha-intercalated cell	6 studies	45% ± 18%	Explore
erythroblast	6 studies	56% ± 31%	Explore
transit amplifying cell	6 studies	53% ± 22%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	57% ± 11%	Explore
glutamatergic neuron	6 studies	36% ± 14%	Explore
oligodendrocyte	6 studies	24% ± 7%	Explore
CD4-positive helper T cell	5 studies	38% ± 16%	Explore
hematopoietic precursor cell	5 studies	73% ± 20%	Explore
exhausted T cell	5 studies	54% ± 12%	Explore
ionocyte	5 studies	43% ± 11%	Explore
kidney loop of Henle epithelial cell	5 studies	37% ± 3%	Explore
enterocyte	5 studies	34% ± 16%	Explore
enteroendocrine cell	5 studies	57% ± 21%	Explore
IgA plasma cell	5 studies	22% ± 7%	Explore
IgG plasma cell	5 studies	23% ± 8%	Explore
pro-B cell	5 studies	59% ± 21%	Explore
T-helper 17 cell	5 studies	59% ± 21%	Explore
group 3 innate lymphoid cell	5 studies	61% ± 15%	Explore
hepatocyte	5 studies	48% ± 29%	Explore
granulocyte	5 studies	42% ± 9%	Explore
GABAergic neuron	5 studies	30% ± 10%	Explore
interneuron	5 studies	34% ± 16%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	41% ± 15%	Explore
deuterosomal cell	4 studies	42% ± 12%	Explore
pancreatic A cell	4 studies	56% ± 11%	Explore
type B pancreatic cell	4 studies	48% ± 20%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	64% ± 24%	Explore
intestinal crypt stem cell	4 studies	60% ± 12%	Explore
retinal ganglion cell	4 studies	45% ± 27%	Explore
lymphocyte	4 studies	57% ± 19%	Explore
amacrine cell	4 studies	44% ± 18%	Explore
retina horizontal cell	4 studies	36% ± 17%	Explore
retinal cone cell	4 studies	51% ± 23%	Explore
retinal rod cell	4 studies	36% ± 15%	Explore
adventitial cell	4 studies	39% ± 8%	Explore
mucus secreting cell	4 studies	25% ± 6%	Explore
acinar cell	4 studies	52% ± 21%	Explore
muscle cell	4 studies	41% ± 16%	Explore
germinal center B cell	4 studies	49% ± 16%	Explore
intermediate monocyte	4 studies	51% ± 22%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	64% ± 3%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	78% ± 24%	Explore
keratinocyte	4 studies	58% ± 25%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	39% ± 8%	Explore
double negative thymocyte	4 studies	63% ± 15%	Explore
duct epithelial cell	3 studies	44% ± 1%	Explore
hillock cell	3 studies	55% ± 25%	Explore
precursor cell	3 studies	82% ± 9%	Explore
pancreatic D cell	3 studies	49% ± 15%	Explore
glomerular endothelial cell	3 studies	27% ± 5%	Explore
neural crest cell	3 studies	85% ± 4%	Explore
retinal bipolar neuron	3 studies	45% ± 12%	Explore
extravillous trophoblast	3 studies	79% ± 1%	Explore
placental villous trophoblast	3 studies	68% ± 4%	Explore
megakaryocyte	3 studies	38% ± 10%	Explore
neuroendocrine cell	3 studies	59% ± 24%	Explore
Schwann cell	3 studies	41% ± 25%	Explore
serous secreting cell	3 studies	39% ± 16%	Explore
adipocyte	3 studies	20% ± 3%	Explore
tissue-resident macrophage	3 studies	30% ± 9%	Explore
intraepithelial lymphocyte	3 studies	50% ± 21%	Explore
Mueller cell	3 studies	30% ± 6%	Explore
rod bipolar cell	3 studies	33% ± 11%	Explore
myoepithelial cell	3 studies	69% ± 5%	Explore
inflammatory macrophage	3 studies	27% ± 7%	Explore
luminal cell of prostate epithelium	3 studies	31% ± 9%	Explore
pancreatic ductal cell	3 studies	69% ± 9%	Explore
granulocyte monocyte progenitor cell	3 studies	59% ± 29%	Explore
neutrophil	3 studies	23% ± 7%	Explore
glial cell	3 studies	49% ± 29%	Explore
melanocyte	3 studies	28% ± 11%	Explore
T-helper 1 cell	3 studies	62% ± 14%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	51% ± 3%	Explore
double-positive, alpha-beta thymocyte	3 studies	66% ± 8%	Explore
progenitor cell of mammary luminal epithelium	3 studies	60% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	19 studies	46% ± 19%	Explore
peripheral blood	19 studies	46% ± 15%	Explore
intestine	11 studies	44% ± 21%	Explore
brain	10 studies	32% ± 8%	Explore
kidney	9 studies	39% ± 16%	Explore
eye	8 studies	34% ± 14%	Explore
liver	8 studies	42% ± 24%	Explore
lymph node	6 studies	49% ± 16%	Explore
pancreas	5 studies	48% ± 19%	Explore
bone marrow	5 studies	42% ± 18%	Explore
uterus	5 studies	57% ± 21%	Explore
breast	4 studies	56% ± 8%	Explore
placenta	3 studies	68% ± 9%	Explore
adrenal gland	3 studies	38% ± 16%	Explore
esophagus	3 studies	56% ± 29%	Explore
thymus	3 studies	60% ± 32%	Explore
prostate	3 studies	56% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	14490.45	1445 / 1445	100%	158.69	183 / 183
liver	100%	7437.21	226 / 226	100%	75.46	406 / 406
ovary	100%	11374.77	180 / 180	100%	135.85	430 / 430
prostate	100%	9998.12	245 / 245	100%	123.98	502 / 502
stomach	100%	9286.00	359 / 359	100%	136.33	286 / 286
uterus	100%	11883.46	170 / 170	100%	182.32	459 / 459
lung	100%	10380.01	577 / 578	100%	128.02	1155 / 1155
intestine	100%	11439.31	966 / 966	100%	135.67	526 / 527
bladder	100%	11874.95	21 / 21	100%	132.15	503 / 504
skin	100%	20549.99	1809 / 1809	100%	140.29	471 / 472
breast	100%	14703.30	459 / 459	100%	139.80	1115 / 1118
thymus	100%	10677.92	653 / 653	100%	123.02	603 / 605
pancreas	99%	8529.32	326 / 328	100%	97.62	178 / 178
brain	99%	6066.83	2622 / 2642	100%	101.52	705 / 705
kidney	100%	8891.73	89 / 89	97%	90.24	876 / 901
adrenal gland	100%	9852.43	258 / 258	83%	41.92	191 / 230
adipose	100%	14831.72	1204 / 1204	0%	0	0 / 0
blood vessel	100%	12557.95	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	155.33	29 / 29
muscle	100%	17867.13	803 / 803	0%	0	0 / 0
spleen	100%	9226.28	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	185.00	45 / 45
ureter	0%	0	0 / 0	100%	67.98	1 / 1
heart	96%	7181.02	826 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	95%	84.38	76 / 80
peripheral blood	92%	12517.40	851 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0043488	Biological process	regulation of mRNA stability
GO_0141014	Biological process	ribosome hibernation
GO_0030578	Biological process	PML body organization
GO_0017148	Biological process	negative regulation of translation
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0043228	Cellular component	non-membrane-bounded organelle
GO_0005634	Cellular component	nucleus
GO_0030371	Molecular function	translation repressor activity
GO_0043022	Molecular function	ribosome binding
GO_0045296	Molecular function	cadherin binding
GO_0061770	Molecular function	translation elongation factor binding
GO_0032183	Molecular function	SUMO binding
GO_0003723	Molecular function	RNA binding
GO_0003730	Molecular function	mRNA 3'-UTR binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SERBP1
Protein name	SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein)
Synonyms	PAIRBP1 CGI-55
Description	FUNCTION: Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation . Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay . Seems to play a role in PML-nuclear bodies formation . .
Accessions	Q8NC51 ENST00000370990.5 [Q8NC51-2] ENST00000361219.11 [Q8NC51-3] ENST00000370994.8 [Q8NC51-4] ENST00000370995.6 [Q8NC51-1]

SERBP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review