SEC61G report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045047Biological processprotein targeting to ER
GO_0031204Biological processpost-translational protein targeting to membrane, translocation
GO_0071261Cellular componentSsh1 translocon complex
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0043022Molecular functionribosome binding
GO_0008320Molecular functionprotein transmembrane transporter activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSEC61G
Protein nameProtein transport protein Sec61 subunit gamma
Synonyms
DescriptionFUNCTION: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (By similarity). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (By similarity). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex . The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity). .

AccessionsENST00000415949.5
P60059
ENST00000352861.9
ENST00000395535.7
ENST00000450622.1