SCP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008206Biological processbile acid metabolic process
GO_0015914Biological processphospholipid transport
GO_0032385Biological processpositive regulation of intracellular cholesterol transport
GO_0032367Biological processintracellular cholesterol transport
GO_1901373Biological processlipid hydroperoxide transport
GO_0036109Biological processalpha-linolenic acid metabolic process
GO_0006699Biological processbile acid biosynthetic process
GO_0006635Biological processfatty acid beta-oxidation
GO_0033540Biological processfatty acid beta-oxidation using acyl-CoA oxidase
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005777Cellular componentperoxisome
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005782Cellular componentperoxisomal matrix
GO_0003988Molecular functionacetyl-CoA C-acyltransferase activity
GO_0033814Molecular functionpropanoyl-CoA C-acyltransferase activity
GO_0015485Molecular functioncholesterol binding
GO_0050632Molecular functionpropionyl-CoA C2-trimethyltridecanoyltransferase activity
GO_0005102Molecular functionsignaling receptor binding
GO_0050633Molecular functionacetyl-CoA C-myristoyltransferase activity
GO_0036042Molecular functionlong-chain fatty acyl-CoA binding
GO_0000062Molecular functionfatty-acyl-CoA binding
GO_0070538Molecular functionoleic acid binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSCP2
Protein nameAlternative protein SCP2
Sterol carrier protein 2
Sterol carrier protein 2 (SCP-2) (Acetyl-CoA C-myristoyltransferase) (EC 2.3.1.155) (Non-specific lipid-transfer protein) (NSL-TP) (Propanoyl-CoA C-acyltransferase) (EC 2.3.1.176) (SCP-2/3-oxoacyl-CoA thiolase) (SCP-2/thiolase) (EC 2.3.1.16) (SCP-chi) (SCPX) (Sterol carrier protein X) (SCP-X)
propanoyl-CoA C-acyltransferase (EC 2.3.1.176) (Propanoyl-CoA C-acyltransferase)
Synonyms
DescriptionFUNCTION: [Isoform SCPx]: Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids . Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA) . Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (By similarity). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity). .; FUNCTION: [Isoform SCP2]: Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis . Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol (By similarity). Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity). .

AccessionsH0YEU8
H0YF61
ENST00000478274.6
ENST00000371514.8 [P22307-1]
ENST00000488965.1 [P22307-5]
P22307
ENST00000408941.7 [P22307-5]
ENST00000478631.6
ENST00000528311.5 [P22307-4]
ENST00000533119.1
H0YCB0
ENST00000484100.5
ENST00000435345.6 [P22307-2]
E9PLD1
H0YD06
ENST00000371509.8 [P22307-7]
L0R5C7
ENST00000407246.6 [P22307-8]
ENST00000529363.2
ENST00000430330.6 [P22307-6]
ENST00000371513.9 [P22307-3]