RAB11A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	46 studies	48% ± 18%	Explore
fibroblast	32 studies	29% ± 12%	Explore
natural killer cell	28 studies	24% ± 8%	Explore
endothelial cell of lymphatic vessel	28 studies	70% ± 16%	Explore
macrophage	28 studies	27% ± 10%	Explore
B cell	26 studies	28% ± 9%	Explore
CD4-positive, alpha-beta T cell	25 studies	24% ± 6%	Explore
pericyte	24 studies	27% ± 9%	Explore
conventional dendritic cell	23 studies	28% ± 13%	Explore
CD8-positive, alpha-beta T cell	23 studies	25% ± 7%	Explore
epithelial cell	22 studies	46% ± 20%	Explore
T cell	21 studies	27% ± 10%	Explore
smooth muscle cell	21 studies	23% ± 6%	Explore
non-classical monocyte	20 studies	28% ± 12%	Explore
basal cell	20 studies	38% ± 19%	Explore
regulatory T cell	20 studies	23% ± 6%	Explore
ciliated cell	19 studies	47% ± 16%	Explore
classical monocyte	18 studies	24% ± 9%	Explore
monocyte	17 studies	28% ± 16%	Explore
dendritic cell	17 studies	33% ± 14%	Explore
capillary endothelial cell	16 studies	46% ± 18%	Explore
naive B cell	15 studies	20% ± 5%	Explore
mast cell	15 studies	29% ± 15%	Explore
astrocyte	14 studies	39% ± 16%	Explore
memory B cell	14 studies	21% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	22% ± 5%	Explore
endothelial cell of artery	13 studies	40% ± 11%	Explore
vein endothelial cell	13 studies	54% ± 12%	Explore
endothelial cell of vascular tree	13 studies	47% ± 11%	Explore
type I pneumocyte	12 studies	28% ± 12%	Explore
secretory cell	12 studies	41% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	20% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	23% ± 5%	Explore
mature NK T cell	12 studies	21% ± 6%	Explore
connective tissue cell	12 studies	30% ± 10%	Explore
gamma-delta T cell	12 studies	24% ± 12%	Explore
neuron	11 studies	41% ± 18%	Explore
goblet cell	11 studies	36% ± 16%	Explore
microglial cell	11 studies	36% ± 14%	Explore
platelet	10 studies	47% ± 15%	Explore
club cell	10 studies	37% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	23% ± 4%	Explore
GABAergic neuron	10 studies	41% ± 16%	Explore
glutamatergic neuron	10 studies	47% ± 20%	Explore
oligodendrocyte precursor cell	10 studies	33% ± 14%	Explore
myofibroblast cell	10 studies	27% ± 4%	Explore
progenitor cell	10 studies	28% ± 10%	Explore
plasmacytoid dendritic cell	10 studies	28% ± 10%	Explore
myeloid cell	10 studies	31% ± 13%	Explore
type II pneumocyte	10 studies	31% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	24% ± 4%	Explore
oligodendrocyte	9 studies	30% ± 12%	Explore
mesothelial cell	9 studies	33% ± 13%	Explore
abnormal cell	9 studies	33% ± 13%	Explore
mucosal invariant T cell	9 studies	21% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	26% ± 9%	Explore
adipocyte	8 studies	29% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	25% ± 8%	Explore
respiratory goblet cell	7 studies	42% ± 19%	Explore
epithelial cell of proximal tubule	7 studies	23% ± 5%	Explore
lymphocyte	7 studies	46% ± 23%	Explore
kidney loop of Henle epithelial cell	6 studies	34% ± 7%	Explore
megakaryocyte	6 studies	67% ± 21%	Explore
transit amplifying cell	6 studies	29% ± 19%	Explore
hematopoietic stem cell	6 studies	38% ± 16%	Explore
precursor B cell	6 studies	36% ± 13%	Explore
plasma cell	6 studies	26% ± 10%	Explore
alveolar macrophage	6 studies	31% ± 9%	Explore
T follicular helper cell	6 studies	20% ± 2%	Explore
hematopoietic precursor cell	5 studies	37% ± 11%	Explore
ionocyte	5 studies	32% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	32% ± 9%	Explore
leukocyte	5 studies	29% ± 12%	Explore
renal alpha-intercalated cell	5 studies	42% ± 4%	Explore
enterocyte	5 studies	33% ± 5%	Explore
enteroendocrine cell	5 studies	44% ± 19%	Explore
retinal ganglion cell	5 studies	61% ± 25%	Explore
pro-B cell	5 studies	42% ± 10%	Explore
brush cell	5 studies	32% ± 20%	Explore
retina horizontal cell	5 studies	54% ± 21%	Explore
retinal rod cell	5 studies	30% ± 12%	Explore
cardiac muscle cell	5 studies	32% ± 4%	Explore
mononuclear phagocyte	5 studies	32% ± 10%	Explore
Mueller cell	5 studies	44% ± 20%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	25% ± 7%	Explore
interneuron	5 studies	59% ± 15%	Explore
deuterosomal cell	4 studies	42% ± 9%	Explore
duct epithelial cell	4 studies	33% ± 12%	Explore
squamous epithelial cell	4 studies	50% ± 19%	Explore
pancreatic A cell	4 studies	70% ± 19%	Explore
type B pancreatic cell	4 studies	54% ± 26%	Explore
exhausted T cell	4 studies	30% ± 4%	Explore
glomerular endothelial cell	4 studies	41% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	42% ± 4%	Explore
erythroblast	4 studies	34% ± 17%	Explore
innate lymphoid cell	4 studies	21% ± 3%	Explore
immature B cell	4 studies	32% ± 9%	Explore
amacrine cell	4 studies	45% ± 4%	Explore
retinal cone cell	4 studies	34% ± 11%	Explore
mucus secreting cell	4 studies	26% ± 6%	Explore
ON-bipolar cell	4 studies	39% ± 19%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	32% ± 3%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	42% ± 6%	Explore
luminal cell of prostate epithelium	4 studies	28% ± 8%	Explore
muscle cell	4 studies	37% ± 14%	Explore
keratinocyte	4 studies	32% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	27% ± 5%	Explore
plasmablast	3 studies	49% ± 7%	Explore
hillock cell	3 studies	31% ± 8%	Explore
precursor cell	3 studies	24% ± 6%	Explore
pancreatic D cell	3 studies	69% ± 26%	Explore
interstitial cell of Cajal	3 studies	37% ± 13%	Explore
intestinal crypt stem cell	3 studies	27% ± 9%	Explore
neural crest cell	3 studies	28% ± 6%	Explore
extravillous trophoblast	3 studies	52% ± 11%	Explore
placental villous trophoblast	3 studies	66% ± 14%	Explore
neuroendocrine cell	3 studies	54% ± 24%	Explore
retinal bipolar neuron	3 studies	28% ± 3%	Explore
retinal pigment epithelial cell	3 studies	55% ± 24%	Explore
serous secreting cell	3 studies	31% ± 7%	Explore
glial cell	3 studies	30% ± 16%	Explore
rod bipolar cell	3 studies	52% ± 25%	Explore
germinal center B cell	3 studies	27% ± 2%	Explore
intermediate monocyte	3 studies	31% ± 14%	Explore
endothelial cell of sinusoid	3 studies	33% ± 9%	Explore
hepatocyte	3 studies	61% ± 28%	Explore
pancreatic ductal cell	3 studies	67% ± 15%	Explore
ependymal cell	3 studies	41% ± 16%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	58% ± 28%	Explore
adventitial cell	3 studies	25% ± 2%	Explore
erythrocyte	3 studies	66% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	25% ± 11%	Explore
T-helper 17 cell	3 studies	22% ± 5%	Explore
granule cell	3 studies	35% ± 18%	Explore
T-helper 1 cell	3 studies	27% ± 3%	Explore
double negative thymocyte	3 studies	37% ± 17%	Explore
myoepithelial cell	3 studies	24% ± 4%	Explore
progenitor cell of mammary luminal epithelium	3 studies	19% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	20 studies	36% ± 16%	Explore
brain	16 studies	35% ± 17%	Explore
peripheral blood	14 studies	24% ± 6%	Explore
kidney	9 studies	26% ± 3%	Explore
intestine	8 studies	28% ± 10%	Explore
eye	8 studies	35% ± 18%	Explore
heart	5 studies	29% ± 4%	Explore
lymph node	5 studies	24% ± 6%	Explore
pancreas	4 studies	59% ± 23%	Explore
bone marrow	4 studies	24% ± 10%	Explore
uterus	4 studies	33% ± 19%	Explore
prostate	4 studies	26% ± 7%	Explore
breast	4 studies	27% ± 4%	Explore
liver	4 studies	40% ± 21%	Explore
adipose	4 studies	24% ± 6%	Explore
placenta	3 studies	54% ± 10%	Explore
adrenal gland	3 studies	21% ± 3%	Explore
thymus	3 studies	38% ± 15%	Explore
esophagus	3 studies	53% ± 18%	Explore
skin	3 studies	26% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	11878.86	258 / 258	100%	108.64	230 / 230
breast	100%	7531.26	459 / 459	100%	141.71	1118 / 1118
esophagus	100%	9903.03	1445 / 1445	100%	108.35	183 / 183
intestine	100%	6241.88	966 / 966	100%	103.25	527 / 527
lung	100%	7571.12	578 / 578	100%	90.87	1155 / 1155
ovary	100%	4703.23	180 / 180	100%	71.82	430 / 430
prostate	100%	5791.13	245 / 245	100%	159.87	502 / 502
stomach	100%	5689.12	359 / 359	100%	95.61	286 / 286
thymus	100%	7259.38	653 / 653	100%	113.66	605 / 605
brain	100%	6336.24	2639 / 2642	100%	86.05	705 / 705
bladder	100%	6671.76	21 / 21	100%	116.24	503 / 504
uterus	100%	5622.34	170 / 170	100%	106.49	458 / 459
skin	100%	11314.15	1809 / 1809	100%	88.34	470 / 472
kidney	100%	5491.29	89 / 89	99%	80.64	896 / 901
liver	96%	2357.00	217 / 226	98%	44.61	397 / 406
pancreas	92%	2358.84	303 / 328	99%	106.08	176 / 178
adipose	100%	7503.63	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	60.15	29 / 29
spleen	100%	7024.61	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	97.57	45 / 45
ureter	0%	0	0 / 0	100%	84.36	1 / 1
blood vessel	100%	5601.68	1331 / 1335	0%	0	0 / 0
muscle	99%	3533.02	791 / 803	0%	0	0 / 0
heart	98%	4053.79	841 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	96%	59.99	77 / 80
peripheral blood	84%	4389.15	781 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0061512	Biological process	protein localization to cilium
GO_0072659	Biological process	protein localization to plasma membrane
GO_0010971	Biological process	positive regulation of G2/M transition of mitotic cell cycle
GO_0036258	Biological process	multivesicular body assembly
GO_2001135	Biological process	regulation of endocytic recycling
GO_0031175	Biological process	neuron projection development
GO_0060627	Biological process	regulation of vesicle-mediated transport
GO_0010634	Biological process	positive regulation of epithelial cell migration
GO_1903438	Biological process	positive regulation of mitotic cytokinetic process
GO_1902017	Biological process	regulation of cilium assembly
GO_0034394	Biological process	protein localization to cell surface
GO_0010796	Biological process	regulation of multivesicular body size
GO_0032402	Biological process	melanosome transport
GO_0061502	Biological process	early endosome to recycling endosome transport
GO_0090307	Biological process	mitotic spindle assembly
GO_0016192	Biological process	vesicle-mediated transport
GO_1902954	Biological process	regulation of early endosome to recycling endosome transport
GO_0090150	Biological process	establishment of protein localization to membrane
GO_0098887	Biological process	neurotransmitter receptor transport, endosome to postsynaptic membrane
GO_0006887	Biological process	exocytosis
GO_0150093	Biological process	amyloid-beta clearance by transcytosis
GO_0048227	Biological process	plasma membrane to endosome transport
GO_1990182	Biological process	exosomal secretion
GO_1904779	Biological process	regulation of protein localization to centrosome
GO_0030953	Biological process	astral microtubule organization
GO_0043001	Biological process	Golgi to plasma membrane protein transport
GO_0007080	Biological process	mitotic metaphase chromosome alignment
GO_0051650	Biological process	establishment of vesicle localization
GO_0072594	Biological process	establishment of protein localization to organelle
GO_0032465	Biological process	regulation of cytokinesis
GO_0071806	Biological process	protein transmembrane transport
GO_0098978	Cellular component	glutamatergic synapse
GO_0031982	Cellular component	vesicle
GO_0034451	Cellular component	centriolar satellite
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0000922	Cellular component	spindle pole
GO_0055037	Cellular component	recycling endosome
GO_0030666	Cellular component	endocytic vesicle membrane
GO_0005813	Cellular component	centrosome
GO_0070062	Cellular component	extracellular exosome
GO_0032991	Cellular component	protein-containing complex
GO_0055038	Cellular component	recycling endosome membrane
GO_0005794	Cellular component	Golgi apparatus
GO_0005814	Cellular component	centriole
GO_0005802	Cellular component	trans-Golgi network
GO_0032588	Cellular component	trans-Golgi network membrane
GO_0098837	Cellular component	postsynaptic recycling endosome
GO_0000139	Cellular component	Golgi membrane
GO_0005828	Cellular component	kinetochore microtubule
GO_0005829	Cellular component	cytosol
GO_0045335	Cellular component	phagocytic vesicle
GO_0005771	Cellular component	multivesicular body
GO_0030133	Cellular component	transport vesicle
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0032154	Cellular component	cleavage furrow
GO_0030659	Cellular component	cytoplasmic vesicle membrane
GO_0003925	Molecular function	G protein activity
GO_0031489	Molecular function	myosin V binding
GO_0005525	Molecular function	GTP binding
GO_0008017	Molecular function	microtubule binding
GO_0051959	Molecular function	dynein light intermediate chain binding
GO_0005515	Molecular function	protein binding
GO_0019905	Molecular function	syntaxin binding
GO_0003924	Molecular function	GTPase activity

IV. Literature review

[source]

Gene name	RAB11A
Protein name	small monomeric GTPase (EC 3.6.5.2) RAB11A, member RAS oncogene family (cDNA FLJ57160, highly similar to Ras-related protein Rab-11A) Ras-related protein Rab-11A (Rab-11) (EC 3.6.5.2) (YL8) RAB11A, member RAS oncogene family
Synonyms	RAB11
Description	FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion . The small Rab GTPase RAB11A regulates endocytic recycling . Forms a functional Rab11/FIP3/dynein complex that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) . Acts as a major regulator of membrane delivery during cytokinesis . Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes . Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation . On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth . Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-endososomal dependent export route via interaction with WDR44 . .
Accessions	ENST00000564910.5 P62491 ENST00000565075.5 ENST00000261890.7 [P62491-1] ENST00000567671.1 ENST00000569896.1 [P62491-2] H3BSC1 B4DQU5 H3BMH2 H3BN38 ENST00000566233.5

RAB11A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review