PRPF40A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	35 studies	27% ± 7%	Explore
endothelial cell	35 studies	28% ± 10%	Explore
macrophage	32 studies	28% ± 8%	Explore
natural killer cell	32 studies	29% ± 9%	Explore
CD8-positive, alpha-beta T cell	30 studies	27% ± 10%	Explore
fibroblast	28 studies	24% ± 7%	Explore
CD4-positive, alpha-beta T cell	28 studies	26% ± 10%	Explore
conventional dendritic cell	26 studies	31% ± 15%	Explore
T cell	24 studies	27% ± 8%	Explore
smooth muscle cell	20 studies	21% ± 4%	Explore
memory B cell	20 studies	26% ± 7%	Explore
classical monocyte	20 studies	31% ± 11%	Explore
regulatory T cell	20 studies	29% ± 8%	Explore
non-classical monocyte	19 studies	33% ± 12%	Explore
pericyte	19 studies	23% ± 6%	Explore
monocyte	18 studies	29% ± 9%	Explore
plasmacytoid dendritic cell	17 studies	34% ± 10%	Explore
epithelial cell	17 studies	33% ± 20%	Explore
naive B cell	17 studies	26% ± 6%	Explore
dendritic cell	15 studies	34% ± 18%	Explore
ciliated cell	15 studies	34% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	23% ± 8%	Explore
mature NK T cell	15 studies	26% ± 6%	Explore
mast cell	14 studies	24% ± 8%	Explore
endothelial cell of lymphatic vessel	14 studies	24% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	31% ± 9%	Explore
basal cell	14 studies	32% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	29% ± 8%	Explore
myeloid cell	14 studies	30% ± 12%	Explore
gamma-delta T cell	14 studies	31% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	27% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	30% ± 8%	Explore
mucosal invariant T cell	12 studies	25% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	28% ± 7%	Explore
myofibroblast cell	11 studies	23% ± 5%	Explore
connective tissue cell	11 studies	28% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	28% ± 9%	Explore
capillary endothelial cell	10 studies	22% ± 6%	Explore
microglial cell	10 studies	27% ± 8%	Explore
type I pneumocyte	9 studies	22% ± 5%	Explore
vein endothelial cell	9 studies	24% ± 6%	Explore
oligodendrocyte	9 studies	27% ± 10%	Explore
alveolar macrophage	8 studies	25% ± 8%	Explore
plasma cell	8 studies	29% ± 13%	Explore
secretory cell	8 studies	27% ± 11%	Explore
abnormal cell	8 studies	35% ± 10%	Explore
endothelial cell of artery	8 studies	22% ± 4%	Explore
oligodendrocyte precursor cell	8 studies	29% ± 10%	Explore
club cell	8 studies	24% ± 11%	Explore
endothelial cell of vascular tree	8 studies	24% ± 5%	Explore
plasmablast	7 studies	45% ± 20%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	32% ± 11%	Explore
leukocyte	7 studies	29% ± 5%	Explore
progenitor cell	7 studies	28% ± 9%	Explore
neuron	7 studies	35% ± 13%	Explore
precursor B cell	7 studies	40% ± 11%	Explore
astrocyte	7 studies	33% ± 11%	Explore
hematopoietic precursor cell	6 studies	46% ± 17%	Explore
mononuclear phagocyte	6 studies	29% ± 11%	Explore
glutamatergic neuron	6 studies	44% ± 24%	Explore
interneuron	6 studies	35% ± 21%	Explore
hematopoietic stem cell	6 studies	41% ± 11%	Explore
lymphocyte	6 studies	30% ± 10%	Explore
innate lymphoid cell	6 studies	25% ± 4%	Explore
T follicular helper cell	6 studies	23% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	31% ± 10%	Explore
GABAergic neuron	6 studies	38% ± 17%	Explore
goblet cell	6 studies	31% ± 15%	Explore
respiratory goblet cell	5 studies	30% ± 12%	Explore
pro-B cell	5 studies	41% ± 9%	Explore
mesothelial cell	5 studies	22% ± 4%	Explore
type II pneumocyte	5 studies	23% ± 8%	Explore
adipocyte	5 studies	22% ± 3%	Explore
deuterosomal cell	4 studies	26% ± 8%	Explore
pancreatic A cell	4 studies	40% ± 13%	Explore
exhausted T cell	4 studies	36% ± 10%	Explore
glial cell	4 studies	27% ± 13%	Explore
erythroblast	4 studies	45% ± 24%	Explore
brush cell	4 studies	31% ± 18%	Explore
immature B cell	4 studies	30% ± 5%	Explore
retina horizontal cell	4 studies	24% ± 7%	Explore
retinal rod cell	4 studies	19% ± 3%	Explore
Mueller cell	4 studies	18% ± 1%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	35% ± 2%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	26% ± 7%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	53% ± 20%	Explore
enteroendocrine cell	4 studies	27% ± 11%	Explore
erythrocyte	4 studies	37% ± 20%	Explore
transit amplifying cell	4 studies	31% ± 20%	Explore
keratinocyte	4 studies	22% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	23% ± 4%	Explore
ionocyte	3 studies	35% ± 6%	Explore
precursor cell	3 studies	29% ± 10%	Explore
pancreatic D cell	3 studies	33% ± 17%	Explore
type B pancreatic cell	3 studies	42% ± 18%	Explore
glomerular endothelial cell	3 studies	19% ± 2%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	27% ± 9%	Explore
enterocyte	3 studies	17% ± 2%	Explore
intestinal crypt stem cell	3 studies	24% ± 6%	Explore
neural crest cell	3 studies	33% ± 2%	Explore
retinal bipolar neuron	3 studies	23% ± 6%	Explore
granule cell	3 studies	20% ± 4%	Explore
placental villous trophoblast	3 studies	33% ± 7%	Explore
megakaryocyte	3 studies	24% ± 8%	Explore
retinal cone cell	3 studies	23% ± 5%	Explore
tissue-resident macrophage	3 studies	25% ± 5%	Explore
GABAergic amacrine cell	3 studies	18% ± 4%	Explore
glycinergic amacrine cell	3 studies	19% ± 1%	Explore
rod bipolar cell	3 studies	23% ± 3%	Explore
germinal center B cell	3 studies	30% ± 7%	Explore
intermediate monocyte	3 studies	44% ± 23%	Explore
CD4-positive helper T cell	3 studies	27% ± 8%	Explore
muscle cell	3 studies	28% ± 7%	Explore
pancreatic ductal cell	3 studies	49% ± 15%	Explore
granulocyte	3 studies	23% ± 5%	Explore
group 3 innate lymphoid cell	3 studies	39% ± 14%	Explore
T-helper 17 cell	3 studies	32% ± 13%	Explore
T-helper 1 cell	3 studies	29% ± 8%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	24% ± 4%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	23% ± 5%	Explore
double negative thymocyte	3 studies	46% ± 17%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	28% ± 10%	Explore
peripheral blood	16 studies	31% ± 11%	Explore
brain	12 studies	32% ± 17%	Explore
eye	7 studies	23% ± 7%	Explore
intestine	6 studies	24% ± 9%	Explore
kidney	5 studies	24% ± 6%	Explore
lymph node	5 studies	28% ± 8%	Explore
bone marrow	4 studies	30% ± 8%	Explore
uterus	4 studies	30% ± 14%	Explore
breast	4 studies	22% ± 6%	Explore
liver	4 studies	40% ± 17%	Explore
adipose	4 studies	22% ± 4%	Explore
pancreas	3 studies	43% ± 14%	Explore
placenta	3 studies	27% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	5580.85	459 / 459	100%	51.98	1118 / 1118
esophagus	100%	4510.66	1445 / 1445	100%	60.89	183 / 183
lung	100%	5287.06	578 / 578	100%	43.77	1155 / 1155
ovary	100%	4966.64	180 / 180	100%	34.97	430 / 430
brain	100%	2744.36	2637 / 2642	100%	33.49	705 / 705
intestine	100%	4986.32	966 / 966	100%	45.44	526 / 527
bladder	100%	4571.24	21 / 21	100%	39.84	503 / 504
uterus	100%	5455.88	170 / 170	100%	42.63	457 / 459
prostate	100%	4670.24	245 / 245	99%	31.34	499 / 502
thymus	100%	5062.05	653 / 653	99%	35.20	600 / 605
stomach	100%	3659.15	359 / 359	99%	45.52	282 / 286
pancreas	100%	2636.35	327 / 328	99%	33.05	176 / 178
kidney	100%	3630.27	89 / 89	96%	26.12	862 / 901
liver	100%	2507.49	226 / 226	95%	18.73	385 / 406
skin	100%	6717.76	1809 / 1809	94%	36.39	446 / 472
adrenal gland	100%	4416.18	258 / 258	94%	20.76	216 / 230
adipose	100%	5270.20	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4531.97	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	35.05	29 / 29
muscle	100%	3841.68	803 / 803	0%	0	0 / 0
spleen	100%	5488.78	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	42.70	45 / 45
ureter	0%	0	0 / 0	100%	14.44	1 / 1
heart	96%	2351.45	828 / 861	0%	0	0 / 0
peripheral blood	88%	4367.20	814 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	69%	14.26	55 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0008360	Biological process	regulation of cell shape
GO_0051301	Biological process	cell division
GO_0007010	Biological process	cytoskeleton organization
GO_0032465	Biological process	regulation of cytokinesis
GO_0016477	Biological process	cell migration
GO_0045292	Biological process	mRNA cis splicing, via spliceosome
GO_0016363	Cellular component	nuclear matrix
GO_0016607	Cellular component	nuclear speck
GO_0071004	Cellular component	U2-type prespliceosome
GO_0005654	Cellular component	nucleoplasm
GO_0005685	Cellular component	U1 snRNP
GO_0016020	Cellular component	membrane
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	PRPF40A
Protein name	PRPF40A protein HCG1811743, isoform CRA_d (Pre-mRNA processing factor 40 homolog A) Pre-mRNA processing factor 40 homolog A Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6) Pre-mRNA-processing factor 40 homolog A
Synonyms	hCG_1811743 HIP10 FNBP3 HSPC225 HYPA FLAF1 FBP11
Description	FUNCTION: Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. .
Accessions	ENST00000696381.1 [O75400-1] H0YG38 ENST00000410080.8 A0A8Q3SIG7 ENST00000696382.1 ENST00000698773.1 Q05C41 A0A7N4I394 F5H578 ENST00000698772.1 ENST00000448428.2 ENST00000545856.8 A0A8V8TM61 ENST00000493468.7 H7BXZ7 ENST00000354363 O75400 H7C2N3 ENST00000354363.11 [O75400-5] A0A8V8TM87

PRPF40A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review