OST4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	44 studies	62% ± 18%	Explore
natural killer cell	40 studies	62% ± 15%	Explore
macrophage	38 studies	60% ± 20%	Explore
endothelial cell	38 studies	56% ± 22%	Explore
fibroblast	36 studies	63% ± 18%	Explore
CD8-positive, alpha-beta T cell	36 studies	67% ± 18%	Explore
T cell	34 studies	63% ± 18%	Explore
CD4-positive, alpha-beta T cell	33 studies	68% ± 17%	Explore
pericyte	30 studies	59% ± 20%	Explore
conventional dendritic cell	29 studies	73% ± 12%	Explore
plasma cell	27 studies	73% ± 19%	Explore
regulatory T cell	27 studies	70% ± 14%	Explore
classical monocyte	26 studies	64% ± 14%	Explore
plasmacytoid dendritic cell	26 studies	75% ± 19%	Explore
dendritic cell	25 studies	63% ± 23%	Explore
smooth muscle cell	25 studies	62% ± 18%	Explore
non-classical monocyte	24 studies	65% ± 15%	Explore
mast cell	22 studies	59% ± 19%	Explore
monocyte	21 studies	59% ± 21%	Explore
mature NK T cell	21 studies	62% ± 16%	Explore
endothelial cell of lymphatic vessel	20 studies	77% ± 13%	Explore
memory B cell	20 studies	63% ± 12%	Explore
basal cell	20 studies	67% ± 19%	Explore
epithelial cell	20 studies	72% ± 18%	Explore
gamma-delta T cell	19 studies	66% ± 15%	Explore
naive B cell	19 studies	53% ± 13%	Explore
connective tissue cell	19 studies	68% ± 18%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	61% ± 16%	Explore
mucosal invariant T cell	16 studies	62% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	55% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	61% ± 13%	Explore
ciliated cell	15 studies	57% ± 18%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	70% ± 12%	Explore
myeloid cell	14 studies	64% ± 21%	Explore
myofibroblast cell	13 studies	67% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	60% ± 21%	Explore
plasmablast	12 studies	79% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	65% ± 15%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	67% ± 16%	Explore
secretory cell	12 studies	71% ± 20%	Explore
capillary endothelial cell	12 studies	48% ± 18%	Explore
endothelial cell of artery	12 studies	54% ± 19%	Explore
goblet cell	12 studies	58% ± 26%	Explore
vein endothelial cell	12 studies	59% ± 20%	Explore
innate lymphoid cell	11 studies	59% ± 16%	Explore
endothelial cell of vascular tree	11 studies	59% ± 11%	Explore
platelet	10 studies	88% ± 8%	Explore
progenitor cell	10 studies	74% ± 19%	Explore
abnormal cell	10 studies	62% ± 20%	Explore
mesothelial cell	10 studies	72% ± 22%	Explore
erythrocyte	10 studies	58% ± 19%	Explore
type I pneumocyte	9 studies	46% ± 21%	Explore
type II pneumocyte	9 studies	65% ± 26%	Explore
T follicular helper cell	9 studies	72% ± 12%	Explore
club cell	8 studies	68% ± 20%	Explore
leukocyte	8 studies	66% ± 12%	Explore
IgG plasma cell	8 studies	67% ± 20%	Explore
hematopoietic stem cell	8 studies	70% ± 12%	Explore
respiratory goblet cell	7 studies	60% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	73% ± 11%	Explore
epithelial cell of proximal tubule	7 studies	63% ± 17%	Explore
neutrophil	7 studies	45% ± 14%	Explore
enterocyte	7 studies	60% ± 21%	Explore
IgA plasma cell	7 studies	69% ± 21%	Explore
hematopoietic precursor cell	6 studies	63% ± 28%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	77% ± 13%	Explore
mononuclear phagocyte	6 studies	63% ± 24%	Explore
kidney loop of Henle epithelial cell	6 studies	62% ± 8%	Explore
renal alpha-intercalated cell	6 studies	85% ± 4%	Explore
megakaryocyte	6 studies	86% ± 16%	Explore
enteroendocrine cell	6 studies	71% ± 25%	Explore
transit amplifying cell	6 studies	52% ± 28%	Explore
microglial cell	6 studies	46% ± 23%	Explore
precursor B cell	6 studies	58% ± 13%	Explore
neuron	6 studies	59% ± 24%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	75% ± 14%	Explore
alveolar macrophage	5 studies	69% ± 11%	Explore
CD4-positive helper T cell	5 studies	60% ± 11%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	62% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	60% ± 13%	Explore
exhausted T cell	5 studies	79% ± 7%	Explore
ionocyte	5 studies	64% ± 11%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	78% ± 12%	Explore
erythroblast	5 studies	67% ± 19%	Explore
intestinal crypt stem cell	5 studies	58% ± 30%	Explore
brush cell	5 studies	40% ± 27%	Explore
neuroendocrine cell	5 studies	78% ± 17%	Explore
T-helper 17 cell	5 studies	79% ± 10%	Explore
group 3 innate lymphoid cell	5 studies	74% ± 8%	Explore
double negative thymocyte	5 studies	76% ± 10%	Explore
intermediate monocyte	5 studies	80% ± 15%	Explore
granulocyte	5 studies	66% ± 19%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	58% ± 27%	Explore
duct epithelial cell	4 studies	75% ± 1%	Explore
pancreatic A cell	4 studies	72% ± 15%	Explore
type B pancreatic cell	4 studies	69% ± 11%	Explore
glomerular endothelial cell	4 studies	48% ± 14%	Explore
podocyte	4 studies	79% ± 9%	Explore
retinal ganglion cell	4 studies	50% ± 29%	Explore
retinal cone cell	4 studies	63% ± 29%	Explore
lymphocyte	4 studies	82% ± 11%	Explore
pro-B cell	4 studies	59% ± 7%	Explore
immature B cell	4 studies	69% ± 14%	Explore
amacrine cell	4 studies	35% ± 17%	Explore
astrocyte	4 studies	40% ± 17%	Explore
retinal rod cell	4 studies	38% ± 19%	Explore
adventitial cell	4 studies	61% ± 7%	Explore
mucus secreting cell	4 studies	73% ± 23%	Explore
acinar cell	4 studies	58% ± 17%	Explore
muscle cell	4 studies	43% ± 21%	Explore
germinal center B cell	4 studies	63% ± 20%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	79% ± 10%	Explore
IgM plasma cell	4 studies	55% ± 24%	Explore
glial cell	4 studies	51% ± 26%	Explore
T-helper 1 cell	4 studies	81% ± 5%	Explore
deuterosomal cell	3 studies	47% ± 8%	Explore
precursor cell	3 studies	72% ± 15%	Explore
pancreatic D cell	3 studies	67% ± 18%	Explore
monocyte-derived dendritic cell	3 studies	71% ± 28%	Explore
kidney connecting tubule epithelial cell	3 studies	79% ± 12%	Explore
neural crest cell	3 studies	70% ± 11%	Explore
OFF-bipolar cell	3 studies	34% ± 13%	Explore
ON-bipolar cell	3 studies	31% ± 9%	Explore
renal principal cell	3 studies	79% ± 7%	Explore
thymocyte	3 studies	65% ± 15%	Explore
extravillous trophoblast	3 studies	91% ± 4%	Explore
placental villous trophoblast	3 studies	89% ± 6%	Explore
retina horizontal cell	3 studies	38% ± 19%	Explore
serous secreting cell	3 studies	78% ± 13%	Explore
intraepithelial lymphocyte	3 studies	67% ± 12%	Explore
Mueller cell	3 studies	49% ± 8%	Explore
cardiac muscle cell	3 studies	36% ± 16%	Explore
endothelial cell of sinusoid	3 studies	51% ± 11%	Explore
oligodendrocyte	3 studies	23% ± 7%	Explore
myoepithelial cell	3 studies	61% ± 15%	Explore
inflammatory macrophage	3 studies	53% ± 16%	Explore
luminal cell of prostate epithelium	3 studies	81% ± 8%	Explore
glutamatergic neuron	3 studies	21% ± 5%	Explore
pancreatic ductal cell	3 studies	74% ± 8%	Explore
oligodendrocyte precursor cell	3 studies	46% ± 21%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	87% ± 8%	Explore
hepatocyte	3 studies	70% ± 23%	Explore
keratinocyte	3 studies	65% ± 8%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	76% ± 2%	Explore
double-positive, alpha-beta thymocyte	3 studies	75% ± 7%	Explore
progenitor cell of mammary luminal epithelium	3 studies	74% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	66% ± 12%	Explore
lung	18 studies	66% ± 16%	Explore
intestine	13 studies	59% ± 24%	Explore
kidney	9 studies	63% ± 16%	Explore
eye	8 studies	42% ± 17%	Explore
bone marrow	6 studies	56% ± 11%	Explore
lymph node	6 studies	67% ± 8%	Explore
brain	6 studies	41% ± 19%	Explore
liver	6 studies	63% ± 22%	Explore
pancreas	5 studies	64% ± 18%	Explore
uterus	5 studies	66% ± 24%	Explore
placenta	4 studies	75% ± 17%	Explore
prostate	4 studies	61% ± 11%	Explore
breast	4 studies	68% ± 11%	Explore
adrenal gland	3 studies	63% ± 8%	Explore
esophagus	3 studies	67% ± 24%	Explore
skin	3 studies	59% ± 6%	Explore
thymus	3 studies	73% ± 17%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2909.61	1445 / 1445	100%	316.00	183 / 183
ovary	100%	3305.51	180 / 180	100%	799.17	430 / 430
uterus	100%	2706.62	170 / 170	100%	427.42	459 / 459
skin	100%	3516.57	1808 / 1809	100%	434.06	472 / 472
thymus	100%	2888.26	653 / 653	100%	433.18	604 / 605
prostate	100%	3169.37	245 / 245	100%	480.73	501 / 502
pancreas	100%	1744.10	327 / 328	100%	409.99	178 / 178
lung	100%	2839.17	578 / 578	100%	441.54	1151 / 1155
intestine	100%	3132.04	966 / 966	100%	464.84	525 / 527
liver	100%	1755.98	225 / 226	100%	323.57	406 / 406
kidney	100%	3436.08	89 / 89	100%	309.83	897 / 901
breast	100%	2956.69	459 / 459	99%	419.20	1111 / 1118
stomach	100%	2396.50	359 / 359	99%	439.19	284 / 286
bladder	100%	3437.14	21 / 21	99%	489.33	500 / 504
brain	99%	1640.16	2612 / 2642	100%	303.45	705 / 705
adrenal gland	100%	3795.65	258 / 258	99%	391.02	227 / 230
adipose	100%	3085.21	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	565.25	80 / 80
lymph node	0%	0	0 / 0	100%	563.88	29 / 29
peripheral blood	100%	3723.43	929 / 929	0%	0	0 / 0
spleen	100%	3139.73	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	279.98	45 / 45
ureter	0%	0	0 / 0	100%	416.38	1 / 1
blood vessel	100%	3609.80	1334 / 1335	0%	0	0 / 0
muscle	100%	2282.45	800 / 803	0%	0	0 / 0
heart	98%	3391.60	845 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	OST4
Protein name	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4
Synonyms
Description	FUNCTION: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation . N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Specifically involved in maintaining stability of STT3A-containing OST complexes. .
Accessions	ENST00000447619.5 P0C6T2 ENST00000456793.2 ENST00000429985.1

GO_0018279	Biological process	protein N-linked glycosylation via asparagine
GO_0006487	Biological process	protein N-linked glycosylation
GO_0008250	Cellular component	oligosaccharyltransferase complex
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005515	Molecular function	protein binding

OST4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review