OAZ1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	49 studies	80% ± 19%	Explore
macrophage	43 studies	81% ± 22%	Explore
natural killer cell	43 studies	72% ± 21%	Explore
endothelial cell	40 studies	62% ± 22%	Explore
T cell	39 studies	68% ± 25%	Explore
CD8-positive, alpha-beta T cell	39 studies	70% ± 22%	Explore
fibroblast	37 studies	71% ± 20%	Explore
CD4-positive, alpha-beta T cell	33 studies	71% ± 21%	Explore
pericyte	31 studies	68% ± 21%	Explore
conventional dendritic cell	31 studies	88% ± 17%	Explore
dendritic cell	30 studies	80% ± 22%	Explore
classical monocyte	29 studies	91% ± 14%	Explore
plasmacytoid dendritic cell	28 studies	87% ± 11%	Explore
regulatory T cell	27 studies	82% ± 14%	Explore
monocyte	26 studies	83% ± 19%	Explore
plasma cell	26 studies	80% ± 17%	Explore
non-classical monocyte	26 studies	95% ± 9%	Explore
smooth muscle cell	25 studies	73% ± 17%	Explore
mast cell	23 studies	68% ± 23%	Explore
epithelial cell	22 studies	78% ± 20%	Explore
endothelial cell of lymphatic vessel	21 studies	78% ± 15%	Explore
mature NK T cell	21 studies	75% ± 15%	Explore
memory B cell	21 studies	85% ± 17%	Explore
gamma-delta T cell	20 studies	76% ± 20%	Explore
basal cell	20 studies	75% ± 16%	Explore
naive B cell	19 studies	83% ± 10%	Explore
connective tissue cell	19 studies	70% ± 18%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	65% ± 17%	Explore
ciliated cell	17 studies	78% ± 14%	Explore
neutrophil	17 studies	72% ± 21%	Explore
erythrocyte	16 studies	68% ± 26%	Explore
mucosal invariant T cell	16 studies	71% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	71% ± 19%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	73% ± 13%	Explore
myeloid cell	15 studies	79% ± 25%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	69% ± 18%	Explore
capillary endothelial cell	14 studies	54% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	69% ± 20%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	74% ± 21%	Explore
myofibroblast cell	13 studies	73% ± 15%	Explore
endothelial cell of artery	13 studies	60% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	67% ± 23%	Explore
innate lymphoid cell	12 studies	74% ± 16%	Explore
plasmablast	12 studies	87% ± 6%	Explore
secretory cell	12 studies	73% ± 18%	Explore
platelet	11 studies	90% ± 7%	Explore
vein endothelial cell	11 studies	64% ± 16%	Explore
microglial cell	11 studies	57% ± 29%	Explore
endothelial cell of vascular tree	11 studies	76% ± 16%	Explore
type I pneumocyte	10 studies	67% ± 20%	Explore
T follicular helper cell	10 studies	81% ± 10%	Explore
astrocyte	10 studies	38% ± 20%	Explore
progenitor cell	10 studies	76% ± 20%	Explore
goblet cell	10 studies	63% ± 23%	Explore
mesothelial cell	10 studies	69% ± 23%	Explore
IgG plasma cell	10 studies	66% ± 25%	Explore
type II pneumocyte	9 studies	76% ± 25%	Explore
club cell	9 studies	68% ± 21%	Explore
leukocyte	9 studies	86% ± 10%	Explore
abnormal cell	9 studies	76% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	82% ± 18%	Explore
IgA plasma cell	8 studies	68% ± 26%	Explore
hematopoietic stem cell	8 studies	88% ± 7%	Explore
brush cell	8 studies	57% ± 15%	Explore
oligodendrocyte	8 studies	22% ± 7%	Explore
ionocyte	7 studies	72% ± 10%	Explore
respiratory goblet cell	7 studies	64% ± 19%	Explore
mononuclear phagocyte	7 studies	83% ± 22%	Explore
epithelial cell of proximal tubule	7 studies	63% ± 19%	Explore
enterocyte	7 studies	74% ± 21%	Explore
retinal rod cell	7 studies	49% ± 25%	Explore
neuron	7 studies	58% ± 26%	Explore
alveolar macrophage	6 studies	85% ± 22%	Explore
hematopoietic precursor cell	6 studies	73% ± 23%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	86% ± 15%	Explore
kidney loop of Henle epithelial cell	6 studies	59% ± 13%	Explore
renal alpha-intercalated cell	6 studies	84% ± 7%	Explore
enteroendocrine cell	6 studies	74% ± 26%	Explore
erythroblast	6 studies	72% ± 29%	Explore
amacrine cell	6 studies	56% ± 27%	Explore
retinal ganglion cell	6 studies	67% ± 32%	Explore
retinal cone cell	6 studies	63% ± 31%	Explore
precursor B cell	6 studies	88% ± 6%	Explore
immature B cell	6 studies	88% ± 9%	Explore
intermediate monocyte	6 studies	92% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	78% ± 13%	Explore
granulocyte	6 studies	81% ± 21%	Explore
oligodendrocyte precursor cell	6 studies	39% ± 18%	Explore
CD4-positive helper T cell	5 studies	69% ± 14%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	73% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	75% ± 9%	Explore
exhausted T cell	5 studies	90% ± 5%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	76% ± 10%	Explore
megakaryocyte	5 studies	97% ± 2%	Explore
transit amplifying cell	5 studies	67% ± 24%	Explore
neuroendocrine cell	5 studies	85% ± 14%	Explore
glial cell	5 studies	59% ± 17%	Explore
T-helper 17 cell	5 studies	85% ± 9%	Explore
group 3 innate lymphoid cell	5 studies	83% ± 8%	Explore
retina horizontal cell	5 studies	55% ± 25%	Explore
double negative thymocyte	5 studies	85% ± 6%	Explore
GABAergic neuron	5 studies	34% ± 18%	Explore
glutamatergic neuron	5 studies	47% ± 20%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	67% ± 29%	Explore
deuterosomal cell	4 studies	63% ± 16%	Explore
duct epithelial cell	4 studies	78% ± 5%	Explore
pancreatic A cell	4 studies	93% ± 5%	Explore
type B pancreatic cell	4 studies	89% ± 7%	Explore
glomerular endothelial cell	4 studies	60% ± 16%	Explore
podocyte	4 studies	82% ± 9%	Explore
intestinal crypt stem cell	4 studies	78% ± 12%	Explore
OFF-bipolar cell	4 studies	64% ± 26%	Explore
ON-bipolar cell	4 studies	67% ± 25%	Explore
lymphocyte	4 studies	88% ± 4%	Explore
pro-B cell	4 studies	88% ± 3%	Explore
adventitial cell	4 studies	73% ± 14%	Explore
mucus secreting cell	4 studies	68% ± 18%	Explore
Mueller cell	4 studies	50% ± 19%	Explore
acinar cell	4 studies	55% ± 18%	Explore
germinal center B cell	4 studies	92% ± 5%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	89% ± 8%	Explore
IgM plasma cell	4 studies	65% ± 27%	Explore
melanocyte	4 studies	73% ± 16%	Explore
T-helper 1 cell	4 studies	89% ± 4%	Explore
interneuron	4 studies	47% ± 23%	Explore
precursor cell	3 studies	80% ± 7%	Explore
squamous epithelial cell	3 studies	72% ± 16%	Explore
pancreatic D cell	3 studies	90% ± 10%	Explore
monocyte-derived dendritic cell	3 studies	98% ± 1%	Explore
renal beta-intercalated cell	3 studies	86% ± 5%	Explore
kidney connecting tubule epithelial cell	3 studies	82% ± 10%	Explore
neural crest cell	3 studies	78% ± 6%	Explore
paneth cell	3 studies	71% ± 20%	Explore
retinal bipolar neuron	3 studies	78% ± 23%	Explore
GABAergic amacrine cell	3 studies	58% ± 18%	Explore
glycinergic amacrine cell	3 studies	53% ± 19%	Explore
renal principal cell	3 studies	67% ± 8%	Explore
thymocyte	3 studies	81% ± 14%	Explore
extravillous trophoblast	3 studies	93% ± 4%	Explore
placental villous trophoblast	3 studies	97% ± 2%	Explore
retinal pigment epithelial cell	3 studies	62% ± 25%	Explore
serous secreting cell	3 studies	69% ± 6%	Explore
tissue-resident macrophage	3 studies	72% ± 30%	Explore
follicular B cell	3 studies	80% ± 10%	Explore
intraepithelial lymphocyte	3 studies	85% ± 2%	Explore
rod bipolar cell	3 studies	69% ± 22%	Explore
inflammatory macrophage	3 studies	90% ± 6%	Explore
muscle cell	3 studies	47% ± 17%	Explore
myoepithelial cell	3 studies	78% ± 4%	Explore
luminal cell of prostate epithelium	3 studies	85% ± 4%	Explore
pancreatic ductal cell	3 studies	85% ± 2%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	97% ± 2%	Explore
hepatocyte	3 studies	70% ± 18%	Explore
keratinocyte	3 studies	84% ± 10%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	83% ± 1%	Explore
double-positive, alpha-beta thymocyte	3 studies	83% ± 9%	Explore
progenitor cell of mammary luminal epithelium	3 studies	84% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	21 studies	77% ± 14%	Explore
lung	18 studies	74% ± 13%	Explore
intestine	12 studies	69% ± 18%	Explore
brain	11 studies	45% ± 23%	Explore
kidney	9 studies	66% ± 22%	Explore
eye	9 studies	57% ± 23%	Explore
bone marrow	7 studies	60% ± 23%	Explore
lymph node	6 studies	84% ± 9%	Explore
pancreas	5 studies	74% ± 25%	Explore
uterus	5 studies	74% ± 23%	Explore
liver	5 studies	76% ± 17%	Explore
placenta	4 studies	82% ± 19%	Explore
prostate	4 studies	78% ± 24%	Explore
breast	4 studies	83% ± 5%	Explore
heart	3 studies	35% ± 12%	Explore
adipose	3 studies	46% ± 25%	Explore
adrenal gland	3 studies	71% ± 17%	Explore
esophagus	3 studies	72% ± 19%	Explore
skin	3 studies	69% ± 23%	Explore
thymus	3 studies	73% ± 28%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	30060.46	258 / 258	100%	472.51	230 / 230
esophagus	100%	19649.99	1445 / 1445	100%	266.84	183 / 183
kidney	100%	21278.15	89 / 89	100%	255.42	901 / 901
liver	100%	13898.93	226 / 226	100%	256.19	406 / 406
ovary	100%	15649.67	180 / 180	100%	278.90	430 / 430
pancreas	100%	13418.78	328 / 328	100%	349.69	178 / 178
stomach	100%	16932.68	359 / 359	100%	320.41	286 / 286
uterus	100%	17143.86	170 / 170	100%	429.62	459 / 459
skin	100%	23591.74	1808 / 1809	100%	383.10	472 / 472
intestine	100%	21429.53	966 / 966	100%	380.41	526 / 527
lung	100%	26624.82	577 / 578	100%	354.48	1154 / 1155
brain	100%	21750.78	2634 / 2642	100%	308.57	705 / 705
thymus	100%	18582.52	652 / 653	100%	329.84	604 / 605
breast	100%	21708.43	459 / 459	100%	344.59	1114 / 1118
bladder	100%	20535.52	21 / 21	100%	406.41	502 / 504
prostate	100%	18334.20	245 / 245	100%	339.46	500 / 502
adipose	100%	23744.54	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	241.48	80 / 80
lymph node	0%	0	0 / 0	100%	816.31	29 / 29
muscle	100%	27015.94	803 / 803	0%	0	0 / 0
peripheral blood	100%	71851.28	929 / 929	0%	0	0 / 0
spleen	100%	37995.84	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	461.72	45 / 45
ureter	0%	0	0 / 0	100%	304.27	1 / 1
blood vessel	100%	21862.25	1333 / 1335	0%	0	0 / 0
heart	99%	22182.20	855 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	OAZ1
Protein name	OAZ1 protein (Ornithine decarboxylase antizyme 1, isoform CRA_a) Ornithine decarboxylase antizyme 1 Ornithine decarboxylase antizyme 1 (AZ1) (ODC-Az)
Synonyms	hCG_22710 OAZ
Description	FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome . Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC . Stabilizes AZIN2 by interfering with its ubiquitination . Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol . .
Accessions	J3QQY4 ENST00000582888.8 K7EPM6 K7ERW1 P54368 ENST00000602676.6 [P54368-1] ENST00000590943.6 ENST00000588673.3 Q2M222

GO_0045732	Biological process	positive regulation of protein catabolic process
GO_1902268	Biological process	negative regulation of polyamine transmembrane transport
GO_0090316	Biological process	positive regulation of intracellular protein transport
GO_0006596	Biological process	polyamine biosynthetic process
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding
GO_0008073	Molecular function	ornithine decarboxylase inhibitor activity

OAZ1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review