NDUFA4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006123Biological processmitochondrial electron transport, cytochrome c to oxygen
GO_0045333Biological processcellular respiration
GO_0006120Biological processmitochondrial electron transport, NADH to ubiquinone
GO_0055085Biological processtransmembrane transport
GO_1904960Biological processpositive regulation of cytochrome-c oxidase activity
GO_0031966Cellular componentmitochondrial membrane
GO_0005751Cellular componentmitochondrial respiratory chain complex IV
GO_0045271Cellular componentrespiratory chain complex I
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005739Cellular componentmitochondrion
GO_0044877Molecular functionprotein-containing complex binding
GO_0008137Molecular functionNADH dehydrogenase (ubiquinone) activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNDUFA4
Protein nameCytochrome c oxidase subunit NDUFA4 (Complex I-MLRQ) (CI-MLRQ) (NADH-ubiquinone oxidoreductase MLRQ subunit)
Synonyms
DescriptionFUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix . NDUFA4 is required for complex IV maintenance . .

AccessionsO00483
ENST00000339600.6