MYL12B | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	43 studies	52% ± 15%	Explore
endothelial cell	43 studies	67% ± 24%	Explore
natural killer cell	42 studies	67% ± 17%	Explore
fibroblast	39 studies	63% ± 19%	Explore
macrophage	38 studies	56% ± 20%	Explore
CD8-positive, alpha-beta T cell	38 studies	63% ± 21%	Explore
T cell	36 studies	59% ± 21%	Explore
pericyte	35 studies	61% ± 22%	Explore
CD4-positive, alpha-beta T cell	32 studies	66% ± 19%	Explore
conventional dendritic cell	30 studies	71% ± 15%	Explore
smooth muscle cell	27 studies	58% ± 18%	Explore
classical monocyte	27 studies	62% ± 18%	Explore
regulatory T cell	27 studies	66% ± 16%	Explore
dendritic cell	26 studies	64% ± 25%	Explore
endothelial cell of lymphatic vessel	25 studies	72% ± 23%	Explore
plasmacytoid dendritic cell	25 studies	76% ± 15%	Explore
non-classical monocyte	24 studies	79% ± 15%	Explore
epithelial cell	24 studies	76% ± 20%	Explore
mast cell	22 studies	54% ± 21%	Explore
monocyte	22 studies	58% ± 20%	Explore
mature NK T cell	22 studies	64% ± 21%	Explore
basal cell	22 studies	76% ± 19%	Explore
memory B cell	20 studies	56% ± 12%	Explore
naive B cell	20 studies	44% ± 14%	Explore
gamma-delta T cell	19 studies	68% ± 17%	Explore
ciliated cell	18 studies	76% ± 20%	Explore
connective tissue cell	18 studies	66% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	60% ± 18%	Explore
capillary endothelial cell	17 studies	64% ± 22%	Explore
mucosal invariant T cell	16 studies	63% ± 17%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	63% ± 20%	Explore
plasma cell	15 studies	40% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	72% ± 14%	Explore
endothelial cell of artery	15 studies	70% ± 21%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	67% ± 16%	Explore
myeloid cell	14 studies	60% ± 17%	Explore
innate lymphoid cell	13 studies	56% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	68% ± 18%	Explore
neutrophil	13 studies	45% ± 15%	Explore
myofibroblast cell	13 studies	70% ± 13%	Explore
vein endothelial cell	13 studies	67% ± 21%	Explore
endothelial cell of vascular tree	13 studies	67% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	66% ± 23%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	67% ± 16%	Explore
secretory cell	12 studies	83% ± 13%	Explore
type I pneumocyte	10 studies	71% ± 24%	Explore
plasmablast	10 studies	46% ± 22%	Explore
platelet	10 studies	48% ± 17%	Explore
progenitor cell	10 studies	75% ± 11%	Explore
abnormal cell	10 studies	58% ± 20%	Explore
mesothelial cell	10 studies	76% ± 18%	Explore
type II pneumocyte	9 studies	73% ± 23%	Explore
goblet cell	9 studies	65% ± 13%	Explore
T follicular helper cell	9 studies	56% ± 14%	Explore
club cell	8 studies	75% ± 22%	Explore
leukocyte	8 studies	64% ± 9%	Explore
neuron	8 studies	49% ± 26%	Explore
enterocyte	8 studies	70% ± 25%	Explore
hematopoietic stem cell	8 studies	60% ± 19%	Explore
erythrocyte	8 studies	46% ± 19%	Explore
ionocyte	7 studies	74% ± 15%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	77% ± 15%	Explore
epithelial cell of proximal tubule	7 studies	66% ± 12%	Explore
brush cell	7 studies	50% ± 21%	Explore
alveolar macrophage	6 studies	69% ± 21%	Explore
CD4-positive helper T cell	6 studies	56% ± 16%	Explore
hematopoietic precursor cell	6 studies	57% ± 29%	Explore
respiratory goblet cell	6 studies	68% ± 18%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	80% ± 18%	Explore
mononuclear phagocyte	6 studies	61% ± 23%	Explore
kidney loop of Henle epithelial cell	6 studies	68% ± 12%	Explore
renal alpha-intercalated cell	6 studies	85% ± 3%	Explore
megakaryocyte	6 studies	66% ± 21%	Explore
erythroblast	6 studies	40% ± 25%	Explore
precursor B cell	6 studies	59% ± 19%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	78% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	71% ± 11%	Explore
exhausted T cell	5 studies	80% ± 9%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	78% ± 12%	Explore
lymphocyte	5 studies	69% ± 27%	Explore
neuroendocrine cell	5 studies	76% ± 14%	Explore
glial cell	5 studies	56% ± 20%	Explore
T-helper 17 cell	5 studies	71% ± 18%	Explore
group 3 innate lymphoid cell	5 studies	72% ± 11%	Explore
immature B cell	5 studies	65% ± 15%	Explore
astrocyte	5 studies	32% ± 14%	Explore
microglial cell	5 studies	37% ± 18%	Explore
double negative thymocyte	5 studies	80% ± 7%	Explore
intermediate monocyte	5 studies	76% ± 15%	Explore
granulocyte	5 studies	69% ± 14%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	63% ± 28%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	67% ± 15%	Explore
deuterosomal cell	4 studies	59% ± 13%	Explore
duct epithelial cell	4 studies	85% ± 1%	Explore
pancreatic A cell	4 studies	78% ± 13%	Explore
type B pancreatic cell	4 studies	64% ± 20%	Explore
glomerular endothelial cell	4 studies	83% ± 9%	Explore
podocyte	4 studies	87% ± 4%	Explore
enteroendocrine cell	4 studies	72% ± 10%	Explore
intestinal crypt stem cell	4 studies	62% ± 14%	Explore
transit amplifying cell	4 studies	61% ± 14%	Explore
retinal ganglion cell	4 studies	75% ± 22%	Explore
pro-B cell	4 studies	54% ± 8%	Explore
amacrine cell	4 studies	41% ± 17%	Explore
retina horizontal cell	4 studies	43% ± 20%	Explore
adventitial cell	4 studies	66% ± 12%	Explore
mucus secreting cell	4 studies	59% ± 16%	Explore
keratinocyte	4 studies	74% ± 6%	Explore
inflammatory macrophage	4 studies	36% ± 8%	Explore
acinar cell	4 studies	63% ± 21%	Explore
endothelial cell of sinusoid	4 studies	43% ± 18%	Explore
germinal center B cell	4 studies	50% ± 19%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	85% ± 7%	Explore
GABAergic neuron	4 studies	28% ± 6%	Explore
glutamatergic neuron	4 studies	37% ± 13%	Explore
hepatocyte	4 studies	54% ± 21%	Explore
T-helper 1 cell	4 studies	78% ± 13%	Explore
precursor cell	3 studies	77% ± 7%	Explore
squamous epithelial cell	3 studies	67% ± 18%	Explore
pancreatic D cell	3 studies	73% ± 20%	Explore
monocyte-derived dendritic cell	3 studies	74% ± 25%	Explore
kidney connecting tubule epithelial cell	3 studies	79% ± 13%	Explore
renal beta-intercalated cell	3 studies	91% ± 4%	Explore
neural crest cell	3 studies	52% ± 1%	Explore
retinal bipolar neuron	3 studies	43% ± 20%	Explore
renal principal cell	3 studies	79% ± 7%	Explore
thymocyte	3 studies	56% ± 24%	Explore
extravillous trophoblast	3 studies	94% ± 3%	Explore
placental villous trophoblast	3 studies	97% ± 1%	Explore
Schwann cell	3 studies	63% ± 8%	Explore
retinal cone cell	3 studies	55% ± 13%	Explore
retinal rod cell	3 studies	36% ± 11%	Explore
serous secreting cell	3 studies	52% ± 9%	Explore
tissue-resident macrophage	3 studies	46% ± 21%	Explore
intraepithelial lymphocyte	3 studies	76% ± 2%	Explore
Mueller cell	3 studies	37% ± 7%	Explore
chondrocyte	3 studies	61% ± 15%	Explore
melanocyte	3 studies	50% ± 4%	Explore
muscle cell	3 studies	44% ± 19%	Explore
oligodendrocyte	3 studies	19% ± 1%	Explore
IgA plasma cell	3 studies	19% ± 3%	Explore
myoepithelial cell	3 studies	84% ± 5%	Explore
luminal cell of prostate epithelium	3 studies	64% ± 4%	Explore
pancreatic ductal cell	3 studies	94% ± 3%	Explore
oligodendrocyte precursor cell	3 studies	36% ± 10%	Explore
interneuron	3 studies	24% ± 8%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	77% ± 4%	Explore
double-positive, alpha-beta thymocyte	3 studies	83% ± 5%	Explore
progenitor cell of mammary luminal epithelium	3 studies	74% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	67% ± 15%	Explore
lung	19 studies	68% ± 19%	Explore
intestine	13 studies	54% ± 22%	Explore
kidney	9 studies	66% ± 13%	Explore
eye	9 studies	36% ± 17%	Explore
brain	7 studies	39% ± 9%	Explore
bone marrow	6 studies	41% ± 18%	Explore
lymph node	6 studies	61% ± 19%	Explore
liver	6 studies	57% ± 21%	Explore
pancreas	5 studies	68% ± 20%	Explore
uterus	5 studies	73% ± 20%	Explore
placenta	4 studies	78% ± 22%	Explore
skin	4 studies	56% ± 14%	Explore
adipose	4 studies	30% ± 18%	Explore
prostate	4 studies	70% ± 12%	Explore
breast	4 studies	73% ± 4%	Explore
heart	3 studies	36% ± 12%	Explore
adrenal gland	3 studies	62% ± 7%	Explore
esophagus	3 studies	70% ± 24%	Explore
thymus	3 studies	74% ± 19%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	13376.86	21 / 21	100%	942.01	504 / 504
kidney	100%	22927.66	89 / 89	100%	679.00	901 / 901
lung	100%	22219.79	578 / 578	100%	791.03	1155 / 1155
ovary	100%	11271.92	180 / 180	100%	742.11	430 / 430
thymus	100%	18674.43	653 / 653	100%	1108.09	605 / 605
uterus	100%	13916.99	170 / 170	100%	955.72	459 / 459
intestine	100%	14533.79	966 / 966	100%	771.19	526 / 527
stomach	100%	11567.27	359 / 359	100%	666.20	285 / 286
adrenal gland	100%	21227.82	258 / 258	100%	476.15	229 / 230
breast	100%	18530.91	459 / 459	99%	859.93	1112 / 1118
esophagus	100%	15430.26	1445 / 1445	99%	726.01	182 / 183
skin	100%	18547.81	1809 / 1809	99%	480.17	469 / 472
prostate	100%	12876.28	245 / 245	99%	588.68	498 / 502
liver	99%	8462.74	224 / 226	100%	552.58	405 / 406
brain	98%	6834.17	2580 / 2642	99%	314.47	700 / 705
pancreas	97%	6386.04	318 / 328	99%	906.48	177 / 178
adipose	100%	17808.99	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	642.19	29 / 29
spleen	100%	13712.40	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	783.26	45 / 45
ureter	0%	0	0 / 0	100%	867.46	1 / 1
blood vessel	100%	18232.54	1333 / 1335	0%	0	0 / 0
heart	99%	9718.24	854 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	99%	344.03	79 / 80
peripheral blood	99%	14803.68	916 / 929	0%	0	0 / 0
muscle	99%	8007.58	791 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0008360	Biological process	regulation of cell shape
GO_0005903	Cellular component	brush border
GO_0001725	Cellular component	stress fiber
GO_0030016	Cellular component	myofibril
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0016460	Cellular component	myosin II complex
GO_0005938	Cellular component	cell cortex
GO_0030018	Cellular component	Z disc
GO_0045177	Cellular component	apical part of cell
GO_0005737	Cellular component	cytoplasm
GO_0032036	Molecular function	myosin heavy chain binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

Gene name	MYL12B
Protein name	Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1)
Synonyms	MRLC2 MYLC2B
Description	FUNCTION: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. .
Accessions	ENST00000581193.5 ENST00000648965.1 ENST00000400175.9 ENST00000584539.1 O14950 ENST00000237500.10

MYL12B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review