MT2A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	47 studies	55% ± 22%	Explore
fibroblast	44 studies	56% ± 27%	Explore
natural killer cell	42 studies	48% ± 20%	Explore
pericyte	39 studies	70% ± 25%	Explore
CD8-positive, alpha-beta T cell	39 studies	47% ± 19%	Explore
macrophage	38 studies	45% ± 19%	Explore
T cell	32 studies	48% ± 19%	Explore
CD4-positive, alpha-beta T cell	32 studies	38% ± 15%	Explore
smooth muscle cell	30 studies	61% ± 27%	Explore
regulatory T cell	28 studies	44% ± 13%	Explore
classical monocyte	27 studies	46% ± 16%	Explore
conventional dendritic cell	25 studies	36% ± 13%	Explore
non-classical monocyte	24 studies	71% ± 15%	Explore
monocyte	23 studies	48% ± 22%	Explore
mature NK T cell	22 studies	43% ± 12%	Explore
basal cell	22 studies	52% ± 22%	Explore
astrocyte	21 studies	51% ± 18%	Explore
dendritic cell	20 studies	44% ± 17%	Explore
endothelial cell of lymphatic vessel	20 studies	60% ± 16%	Explore
mast cell	19 studies	42% ± 15%	Explore
gamma-delta T cell	19 studies	38% ± 15%	Explore
epithelial cell	19 studies	58% ± 20%	Explore
ciliated cell	17 studies	61% ± 20%	Explore
mucosal invariant T cell	16 studies	42% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	47% ± 12%	Explore
endothelial cell of artery	15 studies	57% ± 28%	Explore
capillary endothelial cell	15 studies	63% ± 25%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	30% ± 10%	Explore
connective tissue cell	14 studies	47% ± 24%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	36% ± 12%	Explore
endothelial cell of vascular tree	14 studies	65% ± 24%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	43% ± 15%	Explore
myofibroblast cell	13 studies	66% ± 25%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	48% ± 16%	Explore
vein endothelial cell	12 studies	54% ± 25%	Explore
B cell	11 studies	32% ± 19%	Explore
plasma cell	11 studies	29% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	35% ± 9%	Explore
secretory cell	11 studies	38% ± 14%	Explore
goblet cell	11 studies	58% ± 24%	Explore
myeloid cell	11 studies	40% ± 20%	Explore
mesothelial cell	10 studies	58% ± 26%	Explore
oligodendrocyte precursor cell	9 studies	27% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	41% ± 14%	Explore
abnormal cell	9 studies	50% ± 25%	Explore
enterocyte	9 studies	58% ± 22%	Explore
type II pneumocyte	8 studies	31% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	62% ± 18%	Explore
erythrocyte	8 studies	33% ± 12%	Explore
T follicular helper cell	8 studies	37% ± 9%	Explore
innate lymphoid cell	8 studies	35% ± 13%	Explore
type I pneumocyte	7 studies	36% ± 13%	Explore
club cell	7 studies	45% ± 12%	Explore
hepatocyte	7 studies	69% ± 30%	Explore
transit amplifying cell	7 studies	47% ± 29%	Explore
adipocyte	7 studies	27% ± 7%	Explore
alveolar macrophage	6 studies	43% ± 19%	Explore
CD4-positive helper T cell	6 studies	26% ± 11%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	51% ± 23%	Explore
leukocyte	6 studies	48% ± 13%	Explore
epithelial cell of proximal tubule	6 studies	55% ± 28%	Explore
kidney loop of Henle epithelial cell	6 studies	57% ± 16%	Explore
progenitor cell	6 studies	53% ± 22%	Explore
glial cell	6 studies	55% ± 25%	Explore
intermediate monocyte	6 studies	55% ± 27%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	33% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	39% ± 10%	Explore
exhausted T cell	5 studies	59% ± 9%	Explore
ionocyte	5 studies	42% ± 10%	Explore
neutrophil	5 studies	37% ± 20%	Explore
respiratory goblet cell	5 studies	44% ± 18%	Explore
plasmacytoid dendritic cell	5 studies	39% ± 24%	Explore
naive B cell	5 studies	21% ± 5%	Explore
mononuclear phagocyte	5 studies	45% ± 22%	Explore
endothelial cell of sinusoid	5 studies	46% ± 14%	Explore
memory B cell	5 studies	23% ± 5%	Explore
adventitial cell	5 studies	70% ± 28%	Explore
double negative thymocyte	5 studies	57% ± 14%	Explore
melanocyte	5 studies	60% ± 20%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	41% ± 18%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	32% ± 13%	Explore
deuterosomal cell	4 studies	69% ± 24%	Explore
plasmablast	4 studies	32% ± 11%	Explore
cholangiocyte	4 studies	48% ± 30%	Explore
glomerular endothelial cell	4 studies	88% ± 6%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	67% ± 24%	Explore
renal alpha-intercalated cell	4 studies	45% ± 11%	Explore
enteroendocrine cell	4 studies	37% ± 15%	Explore
intestinal crypt stem cell	4 studies	67% ± 29%	Explore
microglial cell	4 studies	30% ± 6%	Explore
erythroblast	4 studies	34% ± 12%	Explore
hematopoietic stem cell	4 studies	22% ± 6%	Explore
retinal pigment epithelial cell	4 studies	49% ± 16%	Explore
Mueller cell	4 studies	57% ± 23%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	76% ± 9%	Explore
luminal cell of prostate epithelium	4 studies	74% ± 13%	Explore
monocyte-derived dendritic cell	4 studies	52% ± 5%	Explore
Schwann cell	4 studies	60% ± 18%	Explore
keratinocyte	4 studies	59% ± 15%	Explore
T-helper 17 cell	4 studies	39% ± 9%	Explore
T-helper 1 cell	4 studies	46% ± 11%	Explore
duct epithelial cell	3 studies	28% ± 18%	Explore
platelet	3 studies	31% ± 19%	Explore
pancreatic A cell	3 studies	20% ± 3%	Explore
type B pancreatic cell	3 studies	44% ± 10%	Explore
hepatic stellate cell	3 studies	57% ± 8%	Explore
podocyte	3 studies	57% ± 23%	Explore
paneth cell	3 studies	76% ± 13%	Explore
renal principal cell	3 studies	52% ± 13%	Explore
common myeloid progenitor	3 studies	32% ± 11%	Explore
lymphocyte	3 studies	64% ± 7%	Explore
brush cell	3 studies	36% ± 8%	Explore
tissue-resident macrophage	3 studies	33% ± 6%	Explore
oligodendrocyte	3 studies	29% ± 12%	Explore
neuron	3 studies	28% ± 12%	Explore
inflammatory macrophage	3 studies	51% ± 17%	Explore
granulocyte	3 studies	51% ± 20%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	33% ± 10%	Explore
progenitor cell of mammary luminal epithelium	3 studies	53% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	19 studies	44% ± 17%	Explore
peripheral blood	19 studies	38% ± 11%	Explore
intestine	15 studies	36% ± 19%	Explore
liver	10 studies	48% ± 17%	Explore
kidney	9 studies	45% ± 21%	Explore
brain	8 studies	29% ± 10%	Explore
uterus	6 studies	53% ± 10%	Explore
pancreas	5 studies	32% ± 8%	Explore
eye	5 studies	32% ± 13%	Explore
heart	5 studies	21% ± 4%	Explore
prostate	5 studies	53% ± 15%	Explore
lymph node	5 studies	46% ± 13%	Explore
adipose	4 studies	30% ± 11%	Explore
breast	4 studies	66% ± 11%	Explore
ovary	3 studies	48% ± 14%	Explore
adrenal gland	3 studies	56% ± 13%	Explore
placenta	3 studies	43% ± 18%	Explore
thymus	3 studies	29% ± 3%	Explore
skin	3 studies	54% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	95%	21497.58	620 / 653	90%	785.68	546 / 605
liver	100%	98731.73	226 / 226	79%	1295.14	319 / 406
breast	90%	28271.55	412 / 459	87%	517.97	969 / 1118
skin	80%	56928.93	1447 / 1809	94%	1353.40	444 / 472
lung	94%	35263.91	544 / 578	77%	499.64	891 / 1155
brain	69%	10233.13	1821 / 2642	99%	1592.15	699 / 705
prostate	72%	19794.40	177 / 245	90%	714.53	454 / 502
adrenal gland	100%	46271.17	257 / 258	63%	1129.94	144 / 230
kidney	87%	22657.20	77 / 89	70%	500.76	633 / 901
pancreas	60%	10710.17	198 / 328	96%	926.43	171 / 178
ovary	60%	8853.88	108 / 180	87%	573.19	372 / 430
stomach	86%	17025.08	307 / 359	49%	179.47	141 / 286
esophagus	59%	8953.65	858 / 1445	73%	564.16	134 / 183
uterus	32%	5020.96	55 / 170	89%	1150.01	407 / 459
intestine	55%	10621.64	527 / 966	53%	254.10	280 / 527
bladder	48%	7318.95	10 / 21	57%	644.64	289 / 504
adipose	91%	49057.75	1098 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	90%	827.97	26 / 29
tonsil	0%	0	0 / 0	89%	882.41	40 / 45
blood vessel	89%	29133.70	1184 / 1335	0%	0	0 / 0
muscle	80%	40702.26	645 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	48%	182.93	38 / 80
heart	42%	6597.59	358 / 861	0%	0	0 / 0
spleen	17%	1518.92	41 / 241	0%	0	0 / 0
peripheral blood	8%	1163.31	73 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0071294	Biological process	cellular response to zinc ion
GO_0036018	Biological process	cellular response to erythropoietin
GO_0071276	Biological process	cellular response to cadmium ion
GO_0071280	Biological process	cellular response to copper ion
GO_0006878	Biological process	intracellular copper ion homeostasis
GO_0036016	Biological process	cellular response to interleukin-3
GO_0010273	Biological process	detoxification of copper ion
GO_0045926	Biological process	negative regulation of growth
GO_0006882	Biological process	intracellular zinc ion homeostasis
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding
GO_0046872	Molecular function	metal ion binding

Gene name	MT2A
Protein name	Metallothionein Metallothionein-2 (MT-2) (Metallothionein-2A) (Metallothionein-II) (MT-II)
Synonyms	MT2 CES1
Description	FUNCTION: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. FUNCTION: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. .
Accessions	ENST00000245185.6 H3BSP9 P02795 ENST00000561491.1

MT2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review