LSM7 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	39 studies	51% ± 14%	Explore
natural killer cell	36 studies	37% ± 13%	Explore
CD8-positive, alpha-beta T cell	34 studies	39% ± 17%	Explore
T cell	29 studies	36% ± 14%	Explore
CD4-positive, alpha-beta T cell	29 studies	41% ± 16%	Explore
fibroblast	29 studies	35% ± 14%	Explore
conventional dendritic cell	27 studies	46% ± 16%	Explore
endothelial cell	26 studies	35% ± 13%	Explore
macrophage	25 studies	31% ± 12%	Explore
classical monocyte	24 studies	34% ± 14%	Explore
non-classical monocyte	23 studies	40% ± 15%	Explore
regulatory T cell	23 studies	40% ± 12%	Explore
smooth muscle cell	20 studies	35% ± 14%	Explore
plasmacytoid dendritic cell	20 studies	45% ± 12%	Explore
epithelial cell	20 studies	48% ± 22%	Explore
pericyte	20 studies	36% ± 12%	Explore
mature NK T cell	19 studies	35% ± 10%	Explore
memory B cell	19 studies	53% ± 9%	Explore
naive B cell	19 studies	51% ± 11%	Explore
basal cell	19 studies	40% ± 17%	Explore
monocyte	17 studies	36% ± 13%	Explore
gamma-delta T cell	17 studies	38% ± 14%	Explore
endothelial cell of lymphatic vessel	16 studies	36% ± 12%	Explore
connective tissue cell	16 studies	42% ± 19%	Explore
mast cell	15 studies	29% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	37% ± 11%	Explore
ciliated cell	15 studies	39% ± 20%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	37% ± 12%	Explore
plasma cell	14 studies	43% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	39% ± 9%	Explore
dendritic cell	13 studies	50% ± 24%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	44% ± 13%	Explore
secretory cell	12 studies	38% ± 18%	Explore
mucosal invariant T cell	12 studies	35% ± 10%	Explore
plasmablast	11 studies	57% ± 23%	Explore
myofibroblast cell	11 studies	44% ± 15%	Explore
vein endothelial cell	11 studies	30% ± 13%	Explore
endothelial cell of vascular tree	11 studies	29% ± 6%	Explore
myeloid cell	11 studies	38% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	39% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	42% ± 15%	Explore
abnormal cell	10 studies	43% ± 16%	Explore
endothelial cell of artery	10 studies	29% ± 9%	Explore
goblet cell	10 studies	41% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	39% ± 14%	Explore
capillary endothelial cell	9 studies	27% ± 13%	Explore
progenitor cell	8 studies	69% ± 8%	Explore
T follicular helper cell	8 studies	39% ± 7%	Explore
club cell	7 studies	41% ± 11%	Explore
leukocyte	7 studies	35% ± 12%	Explore
neuron	7 studies	49% ± 27%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	54% ± 15%	Explore
enterocyte	6 studies	31% ± 13%	Explore
intestinal crypt stem cell	6 studies	41% ± 20%	Explore
mesothelial cell	6 studies	58% ± 18%	Explore
hematopoietic stem cell	6 studies	75% ± 9%	Explore
precursor B cell	6 studies	53% ± 16%	Explore
innate lymphoid cell	6 studies	35% ± 7%	Explore
immature B cell	6 studies	56% ± 21%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	42% ± 15%	Explore
alveolar macrophage	5 studies	23% ± 4%	Explore
CD4-positive helper T cell	5 studies	25% ± 8%	Explore
hematopoietic precursor cell	5 studies	60% ± 27%	Explore
exhausted T cell	5 studies	52% ± 10%	Explore
ionocyte	5 studies	30% ± 12%	Explore
respiratory goblet cell	5 studies	35% ± 20%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	48% ± 13%	Explore
mononuclear phagocyte	5 studies	42% ± 16%	Explore
transit amplifying cell	5 studies	46% ± 20%	Explore
type II pneumocyte	5 studies	46% ± 21%	Explore
erythrocyte	5 studies	43% ± 24%	Explore
type I pneumocyte	4 studies	42% ± 21%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	31% ± 14%	Explore
kidney loop of Henle epithelial cell	4 studies	25% ± 5%	Explore
epithelial cell of proximal tubule	4 studies	32% ± 19%	Explore
enteroendocrine cell	4 studies	57% ± 14%	Explore
erythroblast	4 studies	44% ± 20%	Explore
pro-B cell	4 studies	52% ± 17%	Explore
germinal center B cell	4 studies	50% ± 20%	Explore
intermediate monocyte	4 studies	51% ± 17%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	36% ± 4%	Explore
oligodendrocyte precursor cell	4 studies	40% ± 22%	Explore
granulocyte	4 studies	34% ± 13%	Explore
T-helper 17 cell	4 studies	43% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	36% ± 10%	Explore
double negative thymocyte	4 studies	52% ± 19%	Explore
deuterosomal cell	3 studies	42% ± 7%	Explore
duct epithelial cell	3 studies	25% ± 10%	Explore
precursor cell	3 studies	73% ± 16%	Explore
pancreatic A cell	3 studies	60% ± 12%	Explore
type B pancreatic cell	3 studies	46% ± 13%	Explore
glomerular endothelial cell	3 studies	20% ± 2%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	61% ± 18%	Explore
renal alpha-intercalated cell	3 studies	49% ± 15%	Explore
neural crest cell	3 studies	71% ± 11%	Explore
extravillous trophoblast	3 studies	57% ± 3%	Explore
placental villous trophoblast	3 studies	72% ± 14%	Explore
common myeloid progenitor	3 studies	56% ± 31%	Explore
lymphocyte	3 studies	53% ± 16%	Explore
megakaryocyte	3 studies	29% ± 2%	Explore
brush cell	3 studies	36% ± 20%	Explore
neuroendocrine cell	3 studies	40% ± 15%	Explore
astrocyte	3 studies	23% ± 10%	Explore
microglial cell	3 studies	26% ± 8%	Explore
mucus secreting cell	3 studies	28% ± 8%	Explore
serous secreting cell	3 studies	36% ± 4%	Explore
intraepithelial lymphocyte	3 studies	38% ± 14%	Explore
muscle cell	3 studies	33% ± 14%	Explore
neutrophil	3 studies	18% ± 3%	Explore
myoepithelial cell	3 studies	37% ± 9%	Explore
GABAergic neuron	3 studies	22% ± 4%	Explore
glutamatergic neuron	3 studies	30% ± 5%	Explore
granulocyte monocyte progenitor cell	3 studies	58% ± 20%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	62% ± 25%	Explore
glial cell	3 studies	46% ± 28%	Explore
group 3 innate lymphoid cell	3 studies	43% ± 15%	Explore
keratinocyte	3 studies	32% ± 6%	Explore
T-helper 1 cell	3 studies	50% ± 11%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	41% ± 12%	Explore
progenitor cell of mammary luminal epithelium	3 studies	36% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	42% ± 12%	Explore
lung	17 studies	37% ± 17%	Explore
intestine	12 studies	35% ± 18%	Explore
kidney	7 studies	34% ± 13%	Explore
liver	6 studies	31% ± 19%	Explore
brain	6 studies	24% ± 7%	Explore
lymph node	5 studies	47% ± 10%	Explore
placenta	4 studies	45% ± 20%	Explore
bone marrow	4 studies	31% ± 10%	Explore
eye	4 studies	25% ± 9%	Explore
uterus	4 studies	44% ± 18%	Explore
breast	4 studies	33% ± 3%	Explore
pancreas	3 studies	46% ± 16%	Explore
prostate	3 studies	29% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1195.46	1445 / 1445	100%	70.42	183 / 183
ovary	100%	1489.08	180 / 180	100%	80.40	430 / 430
uterus	100%	1374.74	170 / 170	100%	120.91	459 / 459
brain	100%	1134.07	2638 / 2642	100%	103.46	704 / 705
thymus	100%	1156.93	653 / 653	100%	75.31	603 / 605
stomach	100%	881.09	359 / 359	100%	122.50	285 / 286
intestine	100%	1417.99	966 / 966	100%	154.12	525 / 527
skin	100%	1409.02	1809 / 1809	100%	93.57	470 / 472
prostate	100%	1483.17	245 / 245	99%	86.40	498 / 502
adrenal gland	100%	1026.95	258 / 258	99%	74.41	228 / 230
bladder	100%	1270.95	21 / 21	99%	134.08	499 / 504
lung	100%	1128.91	576 / 578	99%	78.46	1142 / 1155
pancreas	100%	662.59	328 / 328	98%	83.75	175 / 178
breast	100%	1250.70	459 / 459	98%	65.30	1096 / 1118
liver	100%	790.89	226 / 226	98%	55.92	398 / 406
kidney	100%	1237.84	89 / 89	97%	43.65	878 / 901
eye	0%	0	0 / 0	100%	71.47	80 / 80
lymph node	0%	0	0 / 0	100%	191.20	29 / 29
spleen	100%	2056.63	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	96.93	45 / 45
ureter	0%	0	0 / 0	100%	164.55	1 / 1
adipose	100%	1087.42	1202 / 1204	0%	0	0 / 0
blood vessel	100%	1045.41	1331 / 1335	0%	0	0 / 0
muscle	99%	712.25	791 / 803	0%	0	0 / 0
heart	98%	738.58	847 / 861	0%	0	0 / 0
peripheral blood	93%	1066.33	861 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0000956	Biological process	nuclear-transcribed mRNA catabolic process
GO_0046540	Cellular component	U4/U6 x U5 tri-snRNP complex
GO_0071004	Cellular component	U2-type prespliceosome
GO_0071013	Cellular component	catalytic step 2 spliceosome
GO_0120115	Cellular component	Lsm2-8 complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0097526	Cellular component	spliceosomal tri-snRNP complex
GO_0005688	Cellular component	U6 snRNP
GO_1990726	Cellular component	Lsm1-7-Pat1 complex
GO_0071005	Cellular component	U2-type precatalytic spliceosome
GO_0005689	Cellular component	U12-type spliceosomal complex
GO_0005634	Cellular component	nucleus
GO_0017070	Molecular function	U6 snRNA binding
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

Gene name	LSM7
Protein name	LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated U6 snRNA-associated Sm-like protein LSm7
Synonyms
Description	FUNCTION: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) . The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA . .
Accessions	K7ENY5 K7EML7 A0A087X2I5 Q9UK45 ENST00000587502.2 ENST00000252622.15 ENST00000585409.2 ENST00000585395.6

LSM7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review