LSM4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	29 studies	28% ± 12%	Explore
CD4-positive, alpha-beta T cell	24 studies	32% ± 19%	Explore
conventional dendritic cell	23 studies	32% ± 15%	Explore
macrophage	22 studies	28% ± 10%	Explore
CD8-positive, alpha-beta T cell	22 studies	33% ± 17%	Explore
B cell	20 studies	28% ± 11%	Explore
T cell	20 studies	32% ± 13%	Explore
plasmacytoid dendritic cell	17 studies	32% ± 11%	Explore
non-classical monocyte	17 studies	29% ± 14%	Explore
endothelial cell	17 studies	29% ± 12%	Explore
regulatory T cell	17 studies	24% ± 10%	Explore
epithelial cell	16 studies	42% ± 21%	Explore
mast cell	15 studies	25% ± 13%	Explore
gamma-delta T cell	15 studies	27% ± 15%	Explore
ciliated cell	14 studies	38% ± 18%	Explore
naive B cell	14 studies	19% ± 4%	Explore
classical monocyte	14 studies	27% ± 11%	Explore
monocyte	13 studies	28% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	22% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	27% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	25% ± 6%	Explore
mature NK T cell	11 studies	21% ± 4%	Explore
memory B cell	11 studies	20% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	28% ± 9%	Explore
fibroblast	10 studies	32% ± 8%	Explore
abnormal cell	10 studies	32% ± 15%	Explore
dendritic cell	10 studies	44% ± 24%	Explore
basal cell	9 studies	35% ± 19%	Explore
progenitor cell	9 studies	42% ± 15%	Explore
endothelial cell of lymphatic vessel	9 studies	27% ± 9%	Explore
pericyte	9 studies	29% ± 11%	Explore
smooth muscle cell	9 studies	29% ± 8%	Explore
mucosal invariant T cell	9 studies	22% ± 3%	Explore
myeloid cell	9 studies	33% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	26% ± 10%	Explore
connective tissue cell	8 studies	36% ± 14%	Explore
plasmablast	7 studies	46% ± 20%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	29% ± 8%	Explore
myofibroblast cell	7 studies	29% ± 8%	Explore
goblet cell	7 studies	32% ± 15%	Explore
T follicular helper cell	7 studies	19% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	24% ± 8%	Explore
capillary endothelial cell	6 studies	23% ± 8%	Explore
epithelial cell of proximal tubule	6 studies	32% ± 8%	Explore
endothelial cell of artery	6 studies	24% ± 8%	Explore
enterocyte	6 studies	26% ± 10%	Explore
transit amplifying cell	6 studies	41% ± 21%	Explore
plasma cell	6 studies	31% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	34% ± 15%	Explore
innate lymphoid cell	6 studies	23% ± 4%	Explore
hematopoietic precursor cell	5 studies	43% ± 24%	Explore
kidney loop of Henle epithelial cell	5 studies	28% ± 6%	Explore
neuron	5 studies	36% ± 19%	Explore
enteroendocrine cell	5 studies	40% ± 15%	Explore
intestinal crypt stem cell	5 studies	29% ± 14%	Explore
mesothelial cell	5 studies	42% ± 12%	Explore
type II pneumocyte	5 studies	26% ± 15%	Explore
type I pneumocyte	4 studies	30% ± 13%	Explore
secretory cell	4 studies	31% ± 22%	Explore
pancreatic A cell	4 studies	53% ± 16%	Explore
type B pancreatic cell	4 studies	43% ± 17%	Explore
mononuclear phagocyte	4 studies	33% ± 18%	Explore
exhausted T cell	4 studies	30% ± 10%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	46% ± 13%	Explore
renal alpha-intercalated cell	4 studies	39% ± 5%	Explore
vein endothelial cell	4 studies	27% ± 14%	Explore
retinal ganglion cell	4 studies	60% ± 27%	Explore
erythroblast	4 studies	42% ± 21%	Explore
pro-B cell	4 studies	36% ± 3%	Explore
club cell	4 studies	27% ± 7%	Explore
precursor B cell	4 studies	29% ± 13%	Explore
amacrine cell	4 studies	34% ± 18%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	29% ± 6%	Explore
endothelial cell of vascular tree	4 studies	20% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	34% ± 11%	Explore
erythrocyte	4 studies	40% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	18% ± 3%	Explore
deuterosomal cell	3 studies	20% ± 4%	Explore
precursor cell	3 studies	47% ± 21%	Explore
leukocyte	3 studies	43% ± 12%	Explore
neural crest cell	3 studies	60% ± 18%	Explore
retinal bipolar neuron	3 studies	42% ± 18%	Explore
extravillous trophoblast	3 studies	39% ± 21%	Explore
placental villous trophoblast	3 studies	41% ± 18%	Explore
common myeloid progenitor	3 studies	33% ± 12%	Explore
hematopoietic stem cell	3 studies	33% ± 12%	Explore
megakaryocyte	3 studies	26% ± 9%	Explore
immature B cell	3 studies	23% ± 2%	Explore
retina horizontal cell	3 studies	36% ± 15%	Explore
retinal cone cell	3 studies	59% ± 18%	Explore
retinal rod cell	3 studies	31% ± 10%	Explore
microglial cell	3 studies	26% ± 11%	Explore
alveolar macrophage	3 studies	26% ± 0%	Explore
intraepithelial lymphocyte	3 studies	27% ± 9%	Explore
germinal center B cell	3 studies	30% ± 7%	Explore
intermediate monocyte	3 studies	38% ± 14%	Explore
pancreatic ductal cell	3 studies	41% ± 8%	Explore
granulocyte monocyte progenitor cell	3 studies	51% ± 28%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	45% ± 15%	Explore
group 3 innate lymphoid cell	3 studies	38% ± 16%	Explore
T-helper 1 cell	3 studies	33% ± 11%	Explore
T-helper 17 cell	3 studies	42% ± 30%	Explore
double negative thymocyte	3 studies	35% ± 22%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	28% ± 13%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	27% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	14 studies	29% ± 14%	Explore
peripheral blood	14 studies	27% ± 9%	Explore
intestine	9 studies	29% ± 13%	Explore
kidney	7 studies	27% ± 6%	Explore
eye	5 studies	31% ± 13%	Explore
liver	5 studies	30% ± 24%	Explore
lymph node	5 studies	32% ± 15%	Explore
pancreas	4 studies	43% ± 20%	Explore
brain	4 studies	26% ± 5%	Explore
bone marrow	3 studies	23% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2806.50	1445 / 1445	100%	88.77	183 / 183
liver	100%	2882.82	226 / 226	100%	104.68	406 / 406
ovary	100%	2125.79	180 / 180	100%	188.61	430 / 430
uterus	100%	2290.21	170 / 170	100%	165.60	459 / 459
skin	100%	3514.24	1808 / 1809	100%	119.93	472 / 472
brain	100%	3624.24	2639 / 2642	100%	98.89	705 / 705
thymus	100%	3017.93	653 / 653	100%	110.17	604 / 605
intestine	100%	3327.40	966 / 966	100%	151.68	526 / 527
adrenal gland	100%	5279.36	258 / 258	100%	122.55	229 / 230
bladder	100%	2811.43	21 / 21	99%	146.36	501 / 504
stomach	100%	2655.31	359 / 359	99%	124.51	284 / 286
prostate	100%	3058.41	245 / 245	99%	95.36	498 / 502
breast	100%	2490.53	459 / 459	99%	126.64	1108 / 1118
lung	100%	2910.96	576 / 578	99%	117.23	1147 / 1155
kidney	100%	4651.42	89 / 89	99%	73.91	891 / 901
pancreas	100%	1422.13	327 / 328	99%	95.57	176 / 178
adipose	100%	2401.23	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	129.50	80 / 80
lymph node	0%	0	0 / 0	100%	146.43	29 / 29
muscle	100%	3605.70	803 / 803	0%	0	0 / 0
spleen	100%	3355.01	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	139.49	45 / 45
ureter	0%	0	0 / 0	100%	193.78	1 / 1
blood vessel	100%	2045.94	1329 / 1335	0%	0	0 / 0
heart	99%	2504.43	853 / 861	0%	0	0 / 0
peripheral blood	95%	2856.92	881 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000387	Biological process	spliceosomal snRNP assembly
GO_0033962	Biological process	P-body assembly
GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0008380	Biological process	RNA splicing
GO_0000956	Biological process	nuclear-transcribed mRNA catabolic process
GO_0046540	Cellular component	U4/U6 x U5 tri-snRNP complex
GO_0120115	Cellular component	Lsm2-8 complex
GO_0016020	Cellular component	membrane
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0071005	Cellular component	U2-type precatalytic spliceosome
GO_0000932	Cellular component	P-body
GO_0005829	Cellular component	cytosol
GO_0097526	Cellular component	spliceosomal tri-snRNP complex
GO_0005688	Cellular component	U6 snRNP
GO_0005634	Cellular component	nucleus
GO_0042731	Molecular function	PH domain binding
GO_0017070	Molecular function	U6 snRNA binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	LSM4
Protein name	U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein) (GRP) U6 snRNA-associated Sm-like protein LSm4
Synonyms
Description	FUNCTION: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) . The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA . . FUNCTION: Binds specifically to the 3'-terminal U-tract of U6 snRNA. . FUNCTION: Binds specifically to the 3'-terminal U-tract of U6 snRNA. . FUNCTION: Binds specifically to the 3'-terminal U-tract of U6 snRNA. .
Accessions	V9GZ56 U3KQK1 ENST00000252816.10 ENST00000593829.6 ENST00000600289.6 ENST00000594828.7 M0QXB0 Q9Y4Z0

LSM4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review