LSM3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	34 studies	28% ± 10%	Explore
B cell	32 studies	28% ± 13%	Explore
fibroblast	28 studies	29% ± 14%	Explore
endothelial cell	27 studies	30% ± 13%	Explore
macrophage	26 studies	26% ± 11%	Explore
CD8-positive, alpha-beta T cell	24 studies	26% ± 10%	Explore
T cell	23 studies	28% ± 10%	Explore
CD4-positive, alpha-beta T cell	22 studies	26% ± 11%	Explore
smooth muscle cell	21 studies	28% ± 9%	Explore
pericyte	21 studies	29% ± 10%	Explore
conventional dendritic cell	20 studies	30% ± 15%	Explore
classical monocyte	18 studies	26% ± 12%	Explore
epithelial cell	18 studies	38% ± 20%	Explore
regulatory T cell	18 studies	24% ± 6%	Explore
basal cell	16 studies	33% ± 17%	Explore
non-classical monocyte	16 studies	31% ± 15%	Explore
connective tissue cell	16 studies	30% ± 11%	Explore
plasmacytoid dendritic cell	16 studies	33% ± 11%	Explore
endothelial cell of lymphatic vessel	15 studies	31% ± 10%	Explore
ciliated cell	15 studies	33% ± 18%	Explore
naive B cell	15 studies	23% ± 5%	Explore
memory B cell	15 studies	23% ± 6%	Explore
plasma cell	14 studies	37% ± 11%	Explore
monocyte	14 studies	28% ± 10%	Explore
gamma-delta T cell	14 studies	28% ± 14%	Explore
mast cell	13 studies	24% ± 5%	Explore
mature NK T cell	13 studies	25% ± 6%	Explore
myofibroblast cell	13 studies	29% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	27% ± 6%	Explore
capillary endothelial cell	12 studies	21% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	22% ± 5%	Explore
vein endothelial cell	11 studies	24% ± 8%	Explore
dendritic cell	11 studies	35% ± 26%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	23% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	25% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	28% ± 6%	Explore
endothelial cell of artery	10 studies	25% ± 8%	Explore
mucosal invariant T cell	10 studies	21% ± 4%	Explore
plasmablast	9 studies	51% ± 23%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	19% ± 5%	Explore
secretory cell	9 studies	28% ± 16%	Explore
progenitor cell	9 studies	36% ± 11%	Explore
myeloid cell	9 studies	28% ± 13%	Explore
abnormal cell	8 studies	31% ± 10%	Explore
goblet cell	8 studies	29% ± 14%	Explore
type I pneumocyte	7 studies	26% ± 15%	Explore
epithelial cell of proximal tubule	7 studies	38% ± 12%	Explore
enterocyte	7 studies	24% ± 7%	Explore
endothelial cell of vascular tree	7 studies	27% ± 7%	Explore
T follicular helper cell	7 studies	21% ± 3%	Explore
hematopoietic precursor cell	6 studies	38% ± 24%	Explore
club cell	6 studies	32% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	29% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	27% ± 9%	Explore
kidney loop of Henle epithelial cell	6 studies	32% ± 5%	Explore
mesothelial cell	6 studies	35% ± 14%	Explore
innate lymphoid cell	6 studies	25% ± 2%	Explore
leukocyte	5 studies	31% ± 12%	Explore
renal alpha-intercalated cell	5 studies	38% ± 6%	Explore
transit amplifying cell	5 studies	38% ± 21%	Explore
erythroblast	5 studies	46% ± 20%	Explore
precursor B cell	5 studies	30% ± 11%	Explore
pro-B cell	5 studies	32% ± 3%	Explore
type II pneumocyte	5 studies	36% ± 21%	Explore
erythrocyte	5 studies	38% ± 19%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	24% ± 10%	Explore
deuterosomal cell	4 studies	36% ± 10%	Explore
pancreatic A cell	4 studies	53% ± 7%	Explore
type B pancreatic cell	4 studies	46% ± 15%	Explore
mononuclear phagocyte	4 studies	35% ± 13%	Explore
exhausted T cell	4 studies	27% ± 11%	Explore
enteroendocrine cell	4 studies	38% ± 11%	Explore
intestinal crypt stem cell	4 studies	29% ± 12%	Explore
hematopoietic stem cell	4 studies	26% ± 6%	Explore
neuron	4 studies	43% ± 17%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	34% ± 5%	Explore
T-helper 17 cell	4 studies	29% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	21% ± 5%	Explore
duct epithelial cell	3 studies	19% ± 2%	Explore
ionocyte	3 studies	26% ± 7%	Explore
precursor cell	3 studies	39% ± 12%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	36% ± 3%	Explore
neural crest cell	3 studies	48% ± 11%	Explore
IgG plasma cell	3 studies	20% ± 3%	Explore
extravillous trophoblast	3 studies	47% ± 18%	Explore
placental villous trophoblast	3 studies	53% ± 22%	Explore
lymphocyte	3 studies	40% ± 11%	Explore
neuroendocrine cell	3 studies	27% ± 9%	Explore
immature B cell	3 studies	24% ± 3%	Explore
amacrine cell	3 studies	37% ± 13%	Explore
astrocyte	3 studies	28% ± 16%	Explore
retinal cone cell	3 studies	48% ± 16%	Explore
retinal rod cell	3 studies	30% ± 12%	Explore
microglial cell	3 studies	25% ± 8%	Explore
alveolar macrophage	3 studies	24% ± 5%	Explore
Mueller cell	3 studies	30% ± 9%	Explore
neutrophil	3 studies	18% ± 3%	Explore
germinal center B cell	3 studies	34% ± 4%	Explore
intermediate monocyte	3 studies	40% ± 19%	Explore
myoepithelial cell	3 studies	26% ± 10%	Explore
glutamatergic neuron	3 studies	23% ± 6%	Explore
pancreatic ductal cell	3 studies	54% ± 8%	Explore
granulocyte monocyte progenitor cell	3 studies	44% ± 29%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	41% ± 24%	Explore
glial cell	3 studies	34% ± 22%	Explore
hepatocyte	3 studies	44% ± 30%	Explore
group 3 innate lymphoid cell	3 studies	30% ± 15%	Explore
keratinocyte	3 studies	22% ± 5%	Explore
T-helper 1 cell	3 studies	24% ± 2%	Explore
double negative thymocyte	3 studies	39% ± 20%	Explore
progenitor cell of mammary luminal epithelium	3 studies	21% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	15 studies	33% ± 14%	Explore
peripheral blood	15 studies	28% ± 10%	Explore
intestine	9 studies	29% ± 13%	Explore
kidney	8 studies	31% ± 7%	Explore
eye	6 studies	28% ± 13%	Explore
brain	6 studies	22% ± 6%	Explore
liver	6 studies	33% ± 23%	Explore
pancreas	5 studies	42% ± 16%	Explore
bone marrow	5 studies	25% ± 8%	Explore
lymph node	5 studies	23% ± 6%	Explore
placenta	4 studies	35% ± 23%	Explore
uterus	4 studies	35% ± 16%	Explore
breast	4 studies	23% ± 4%	Explore
adrenal gland	3 studies	18% ± 2%	Explore
skin	3 studies	19% ± 3%	Explore
thymus	3 studies	52% ± 16%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1897.30	1445 / 1445	100%	35.51	183 / 183
liver	100%	1222.05	226 / 226	100%	33.75	406 / 406
ovary	100%	1600.96	180 / 180	100%	70.10	430 / 430
pancreas	100%	909.96	328 / 328	100%	34.00	178 / 178
uterus	100%	1614.11	170 / 170	100%	58.84	459 / 459
brain	100%	1647.76	2640 / 2642	100%	49.58	705 / 705
breast	100%	1796.38	459 / 459	100%	53.21	1117 / 1118
lung	100%	1540.16	577 / 578	100%	36.00	1155 / 1155
bladder	100%	1836.10	21 / 21	100%	54.07	503 / 504
prostate	100%	1758.40	245 / 245	100%	46.51	501 / 502
skin	100%	1894.10	1809 / 1809	100%	37.21	471 / 472
thymus	100%	1881.28	653 / 653	100%	45.58	603 / 605
intestine	100%	1948.11	966 / 966	99%	45.48	524 / 527
kidney	100%	2734.00	89 / 89	99%	29.62	895 / 901
stomach	100%	1456.28	359 / 359	99%	46.70	284 / 286
adrenal gland	100%	1681.34	258 / 258	98%	29.36	225 / 230
adipose	100%	1736.66	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	26.45	80 / 80
lymph node	0%	0	0 / 0	100%	71.04	29 / 29
muscle	100%	2127.56	803 / 803	0%	0	0 / 0
spleen	100%	1781.68	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	57.43	45 / 45
ureter	0%	0	0 / 0	100%	41.01	1 / 1
blood vessel	100%	1811.28	1333 / 1335	0%	0	0 / 0
heart	99%	1858.38	853 / 861	0%	0	0 / 0
peripheral blood	44%	905.95	409 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0033962	Biological process	P-body assembly
GO_0006397	Biological process	mRNA processing
GO_0000932	Cellular component	P-body
GO_0046540	Cellular component	U4/U6 x U5 tri-snRNP complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0120115	Cellular component	Lsm2-8 complex
GO_0071011	Cellular component	precatalytic spliceosome
GO_0071013	Cellular component	catalytic step 2 spliceosome
GO_0005688	Cellular component	U6 snRNP
GO_1990726	Cellular component	Lsm1-7-Pat1 complex
GO_0071005	Cellular component	U2-type precatalytic spliceosome
GO_0005634	Cellular component	nucleus
GO_0030629	Molecular function	U6 snRNA 3'-end binding
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

Gene name	LSM3
Protein name	U6 snRNA-associated Sm-like protein LSm3
Synonyms	MDS017
Description	FUNCTION: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) . The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA . . FUNCTION: Binds specifically to the 3'-terminal U-tract of U6 snRNA. .
Accessions	B2R5H5 P62310 ENST00000306024.4

LSM3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review