ILF3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045071Biological processnegative regulation of viral genome replication
GO_0051607Biological processdefense response to virus
GO_0046718Biological processsymbiont entry into host cell
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006468Biological processprotein phosphorylation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0017148Biological processnegative regulation of translation
GO_0005730Cellular componentnucleolus
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0003727Molecular functionsingle-stranded RNA binding
GO_0001618Molecular functionvirus receptor activity
GO_0035925Molecular functionmRNA 3'-UTR AU-rich region binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene nameILF3
Protein nameInterleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80)
ILF3 protein (cDNA FLJ20011 fis, clone ADKA03432) (cDNA: FLJ22168 fis, clone HRC00618)
Interleukin enhancer binding factor 3
Alternative protein ILF3
SynonymsMPHOSPH4
NF90
DRBF
DescriptionFUNCTION: RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs . As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs . Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response . Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs . .; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. .

AccessionsK7EKY0
L8E9J1
K7ENK6
ENST00000590009.5
Q9NXX0
ENST00000407004.8 [Q12906-6]
K7EKJ9
K7EM82
ENST00000593061.5
K7EJ09
ENST00000587840.5
ENST00000250241.12 [Q12906-5]
ENST00000593199.5
K7EMZ8
ENST00000585835.1
ENST00000590261.5 [Q12906-1]
Q12906
ENST00000589052.5
ENST00000590869.1
ENST00000589416.5
ENST00000589283.5
ENST00000587941.1
ENST00000589998.6 [Q12906-2]
K7ELV3
K7EQR9
K7ERM6
K7EQ75
ENST00000592763.5 [Q12906-4]
ENST00000587505.5
ENST00000589485.5
ENST00000589600.5
K7EPG3
ENST00000588657.6 [Q12906-7]
K7ER69