HMGN3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	40 studies	37% ± 16%	Explore
natural killer cell	39 studies	38% ± 13%	Explore
fibroblast	36 studies	39% ± 16%	Explore
B cell	35 studies	30% ± 13%	Explore
macrophage	34 studies	32% ± 12%	Explore
CD8-positive, alpha-beta T cell	30 studies	30% ± 10%	Explore
conventional dendritic cell	28 studies	42% ± 15%	Explore
CD4-positive, alpha-beta T cell	28 studies	26% ± 10%	Explore
smooth muscle cell	27 studies	42% ± 19%	Explore
T cell	26 studies	29% ± 14%	Explore
pericyte	26 studies	39% ± 16%	Explore
endothelial cell of lymphatic vessel	25 studies	43% ± 16%	Explore
dendritic cell	23 studies	43% ± 22%	Explore
basal cell	23 studies	50% ± 24%	Explore
mast cell	22 studies	34% ± 15%	Explore
ciliated cell	21 studies	81% ± 17%	Explore
epithelial cell	21 studies	51% ± 26%	Explore
mature NK T cell	20 studies	35% ± 11%	Explore
non-classical monocyte	20 studies	32% ± 13%	Explore
plasmacytoid dendritic cell	20 studies	49% ± 16%	Explore
classical monocyte	20 studies	32% ± 13%	Explore
astrocyte	18 studies	36% ± 18%	Explore
memory B cell	17 studies	28% ± 7%	Explore
connective tissue cell	17 studies	44% ± 18%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	36% ± 13%	Explore
plasma cell	16 studies	39% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	43% ± 14%	Explore
monocyte	16 studies	36% ± 10%	Explore
gamma-delta T cell	16 studies	35% ± 15%	Explore
myofibroblast cell	15 studies	47% ± 18%	Explore
naive B cell	15 studies	25% ± 6%	Explore
oligodendrocyte	14 studies	31% ± 14%	Explore
regulatory T cell	14 studies	25% ± 7%	Explore
capillary endothelial cell	13 studies	28% ± 12%	Explore
type I pneumocyte	12 studies	47% ± 18%	Explore
type II pneumocyte	12 studies	55% ± 19%	Explore
mesothelial cell	12 studies	54% ± 23%	Explore
vein endothelial cell	12 studies	44% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	35% ± 9%	Explore
plasmablast	11 studies	46% ± 23%	Explore
club cell	11 studies	59% ± 21%	Explore
microglial cell	11 studies	28% ± 11%	Explore
mucosal invariant T cell	11 studies	27% ± 7%	Explore
endothelial cell of vascular tree	11 studies	33% ± 8%	Explore
myeloid cell	11 studies	33% ± 15%	Explore
innate lymphoid cell	10 studies	39% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	27% ± 8%	Explore
secretory cell	10 studies	54% ± 22%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	31% ± 6%	Explore
progenitor cell	10 studies	48% ± 24%	Explore
abnormal cell	9 studies	48% ± 12%	Explore
endothelial cell of artery	9 studies	35% ± 9%	Explore
goblet cell	9 studies	35% ± 18%	Explore
adipocyte	9 studies	36% ± 9%	Explore
oligodendrocyte precursor cell	9 studies	35% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	28% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	32% ± 11%	Explore
epithelial cell of proximal tubule	8 studies	51% ± 20%	Explore
neuron	8 studies	44% ± 16%	Explore
GABAergic neuron	8 studies	37% ± 19%	Explore
glutamatergic neuron	8 studies	43% ± 23%	Explore
respiratory goblet cell	7 studies	46% ± 22%	Explore
amacrine cell	7 studies	48% ± 24%	Explore
retinal ganglion cell	7 studies	51% ± 26%	Explore
retinal cone cell	7 studies	53% ± 27%	Explore
hematopoietic stem cell	7 studies	49% ± 16%	Explore
precursor B cell	7 studies	43% ± 14%	Explore
hematopoietic precursor cell	6 studies	48% ± 26%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	33% ± 9%	Explore
leukocyte	6 studies	39% ± 13%	Explore
mononuclear phagocyte	6 studies	37% ± 19%	Explore
kidney loop of Henle epithelial cell	6 studies	50% ± 7%	Explore
renal alpha-intercalated cell	6 studies	53% ± 14%	Explore
transit amplifying cell	6 studies	35% ± 27%	Explore
retinal rod cell	6 studies	35% ± 20%	Explore
alveolar macrophage	6 studies	28% ± 8%	Explore
mucus secreting cell	6 studies	30% ± 5%	Explore
cardiac muscle cell	6 studies	49% ± 10%	Explore
T follicular helper cell	6 studies	28% ± 8%	Explore
hepatocyte	6 studies	36% ± 26%	Explore
ionocyte	5 studies	45% ± 12%	Explore
podocyte	5 studies	69% ± 21%	Explore
enteroendocrine cell	5 studies	57% ± 22%	Explore
intestinal crypt stem cell	5 studies	29% ± 9%	Explore
retinal bipolar neuron	5 studies	56% ± 29%	Explore
glial cell	5 studies	39% ± 27%	Explore
erythroblast	5 studies	33% ± 13%	Explore
pro-B cell	5 studies	51% ± 9%	Explore
retina horizontal cell	5 studies	60% ± 12%	Explore
Mueller cell	5 studies	41% ± 19%	Explore
interneuron	5 studies	43% ± 19%	Explore
deuterosomal cell	4 studies	57% ± 18%	Explore
duct epithelial cell	4 studies	37% ± 9%	Explore
pancreatic A cell	4 studies	65% ± 10%	Explore
type B pancreatic cell	4 studies	47% ± 17%	Explore
exhausted T cell	4 studies	37% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	61% ± 9%	Explore
IgA plasma cell	4 studies	25% ± 5%	Explore
IgG plasma cell	4 studies	27% ± 6%	Explore
OFF-bipolar cell	4 studies	40% ± 10%	Explore
ON-bipolar cell	4 studies	43% ± 9%	Explore
lymphocyte	4 studies	41% ± 12%	Explore
Schwann cell	4 studies	38% ± 23%	Explore
immature B cell	4 studies	45% ± 17%	Explore
retinal pigment epithelial cell	4 studies	46% ± 24%	Explore
adventitial cell	4 studies	27% ± 10%	Explore
endothelial cell of sinusoid	4 studies	22% ± 5%	Explore
muscle cell	4 studies	41% ± 21%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	29% ± 3%	Explore
intermediate monocyte	4 studies	40% ± 16%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	42% ± 12%	Explore
myoepithelial cell	4 studies	40% ± 15%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	29% ± 5%	Explore
granulocyte	4 studies	36% ± 15%	Explore
erythrocyte	4 studies	31% ± 13%	Explore
group 3 innate lymphoid cell	4 studies	54% ± 12%	Explore
melanocyte	4 studies	26% ± 9%	Explore
keratinocyte	4 studies	27% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	34% ± 5%	Explore
hillock cell	3 studies	33% ± 12%	Explore
precursor cell	3 studies	62% ± 17%	Explore
pancreatic D cell	3 studies	62% ± 16%	Explore
monocyte-derived dendritic cell	3 studies	45% ± 22%	Explore
enterocyte	3 studies	31% ± 10%	Explore
neural crest cell	3 studies	61% ± 20%	Explore
GABAergic amacrine cell	3 studies	47% ± 15%	Explore
glycinergic amacrine cell	3 studies	36% ± 13%	Explore
renal principal cell	3 studies	57% ± 11%	Explore
extravillous trophoblast	3 studies	69% ± 21%	Explore
placental villous trophoblast	3 studies	74% ± 30%	Explore
common myeloid progenitor	3 studies	45% ± 31%	Explore
megakaryocyte	3 studies	31% ± 7%	Explore
neuroendocrine cell	3 studies	70% ± 29%	Explore
serous secreting cell	3 studies	44% ± 16%	Explore
rod bipolar cell	3 studies	72% ± 14%	Explore
germinal center B cell	3 studies	41% ± 5%	Explore
inflammatory macrophage	3 studies	28% ± 11%	Explore
pancreatic ductal cell	3 studies	53% ± 8%	Explore
neural progenitor cell	3 studies	30% ± 11%	Explore
ependymal cell	3 studies	41% ± 18%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	58% ± 29%	Explore
granule cell	3 studies	28% ± 13%	Explore
T-helper 17 cell	3 studies	31% ± 11%	Explore
double negative thymocyte	3 studies	54% ± 22%	Explore
progenitor cell of mammary luminal epithelium	3 studies	46% ± 11%	Explore
luminal cell of prostate epithelium	3 studies	23% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	19 studies	45% ± 18%	Explore
peripheral blood	18 studies	32% ± 12%	Explore
brain	18 studies	33% ± 16%	Explore
eye	11 studies	40% ± 18%	Explore
intestine	10 studies	35% ± 20%	Explore
kidney	9 studies	43% ± 8%	Explore
liver	7 studies	31% ± 13%	Explore
heart	6 studies	32% ± 8%	Explore
pancreas	5 studies	46% ± 19%	Explore
bone marrow	5 studies	26% ± 9%	Explore
uterus	5 studies	42% ± 17%	Explore
lymph node	5 studies	38% ± 16%	Explore
breast	5 studies	29% ± 10%	Explore
placenta	4 studies	49% ± 30%	Explore
esophagus	4 studies	41% ± 30%	Explore
prostate	4 studies	19% ± 4%	Explore
skin	4 studies	29% ± 6%	Explore
adipose	4 studies	26% ± 6%	Explore
ovary	3 studies	22% ± 4%	Explore
adrenal gland	3 studies	35% ± 7%	Explore
thymus	3 studies	60% ± 20%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	2957.40	180 / 180	100%	215.55	430 / 430
thymus	100%	3741.17	653 / 653	100%	241.39	605 / 605
brain	100%	3171.85	2642 / 2642	100%	170.68	704 / 705
prostate	100%	2663.27	245 / 245	100%	123.61	501 / 502
adrenal gland	100%	5275.26	258 / 258	100%	241.66	229 / 230
uterus	100%	2700.28	170 / 170	100%	217.50	457 / 459
lung	100%	3079.99	577 / 578	100%	178.66	1150 / 1155
pancreas	99%	1644.66	326 / 328	100%	125.68	178 / 178
breast	100%	2701.81	459 / 459	99%	137.40	1110 / 1118
kidney	100%	4738.54	89 / 89	98%	241.56	887 / 901
esophagus	100%	2779.96	1445 / 1445	98%	103.26	179 / 183
skin	99%	1657.94	1799 / 1809	98%	118.08	461 / 472
bladder	100%	2583.43	21 / 21	97%	120.29	488 / 504
liver	100%	2115.31	225 / 226	96%	102.41	389 / 406
stomach	100%	2680.03	359 / 359	93%	89.84	267 / 286
intestine	100%	2852.00	966 / 966	93%	87.18	490 / 527
adipose	100%	2357.80	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	202.88	29 / 29
spleen	100%	2904.19	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	173.52	45 / 45
ureter	0%	0	0 / 0	100%	114.80	1 / 1
blood vessel	100%	2762.79	1333 / 1335	0%	0	0 / 0
muscle	99%	2120.50	798 / 803	0%	0	0 / 0
heart	99%	3893.07	852 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	98%	127.57	78 / 80
peripheral blood	33%	1160.10	311 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006325	Biological process	chromatin organization
GO_0008150	Biological process	biological_process
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0046966	Molecular function	nuclear thyroid hormone receptor binding
GO_0031492	Molecular function	nucleosomal DNA binding
GO_0005515	Molecular function	protein binding
GO_0003682	Molecular function	chromatin binding

IV. Literature review

[source]

Gene name	HMGN3
Protein name	High mobility group nucleosome-binding domain-containing protein 3 (Thyroid receptor-interacting protein 7) (TR-interacting protein 7) (TRIP-7) High mobility group nucleosome-binding domain-containing protein 3
Synonyms	PNAS-24 TRIP7
Description	FUNCTION: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity). . FUNCTION: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function. . FUNCTION: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function. . FUNCTION: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function. . FUNCTION: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function. . FUNCTION: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function. .
Accessions	A0A994J3W4 ENST00000703810.2 ENST00000344726.10 [Q15651-1] ENST00000706660.1 A0A9L9PXD4 ENST00000620514.2 ENST00000706657.1 A0A9L9PXC9 Q15651 A0A087WZE9 A0A9L9PY81 ENST00000275036.11 [Q15651-2] ENST00000706659.1

HMGN3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review