GUK1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	43 studies	57% ± 24%	Explore
natural killer cell	39 studies	56% ± 14%	Explore
B cell	38 studies	37% ± 13%	Explore
CD8-positive, alpha-beta T cell	36 studies	57% ± 19%	Explore
macrophage	35 studies	47% ± 14%	Explore
fibroblast	34 studies	52% ± 15%	Explore
T cell	32 studies	50% ± 16%	Explore
CD4-positive, alpha-beta T cell	32 studies	49% ± 16%	Explore
pericyte	29 studies	56% ± 18%	Explore
conventional dendritic cell	27 studies	47% ± 16%	Explore
regulatory T cell	26 studies	48% ± 16%	Explore
smooth muscle cell	25 studies	55% ± 15%	Explore
classical monocyte	25 studies	50% ± 14%	Explore
endothelial cell of lymphatic vessel	24 studies	71% ± 25%	Explore
non-classical monocyte	24 studies	58% ± 16%	Explore
epithelial cell	23 studies	53% ± 24%	Explore
plasma cell	22 studies	52% ± 20%	Explore
plasmacytoid dendritic cell	22 studies	65% ± 15%	Explore
basal cell	21 studies	50% ± 21%	Explore
mature NK T cell	20 studies	55% ± 15%	Explore
dendritic cell	19 studies	50% ± 20%	Explore
gamma-delta T cell	19 studies	58% ± 18%	Explore
memory B cell	19 studies	37% ± 8%	Explore
mast cell	18 studies	38% ± 13%	Explore
monocyte	18 studies	50% ± 14%	Explore
naive B cell	17 studies	31% ± 9%	Explore
connective tissue cell	17 studies	52% ± 15%	Explore
mucosal invariant T cell	16 studies	52% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	37% ± 12%	Explore
ciliated cell	16 studies	56% ± 15%	Explore
capillary endothelial cell	16 studies	55% ± 20%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	50% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	57% ± 18%	Explore
erythrocyte	14 studies	56% ± 21%	Explore
vein endothelial cell	14 studies	62% ± 23%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	54% ± 18%	Explore
myofibroblast cell	13 studies	53% ± 15%	Explore
endothelial cell of artery	13 studies	61% ± 20%	Explore
plasmablast	12 studies	61% ± 19%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	60% ± 20%	Explore
endothelial cell of vascular tree	12 studies	62% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	53% ± 23%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	51% ± 20%	Explore
secretory cell	11 studies	60% ± 14%	Explore
myeloid cell	11 studies	50% ± 15%	Explore
abnormal cell	10 studies	54% ± 23%	Explore
goblet cell	10 studies	45% ± 18%	Explore
type I pneumocyte	9 studies	40% ± 15%	Explore
platelet	9 studies	26% ± 6%	Explore
progenitor cell	9 studies	41% ± 15%	Explore
astrocyte	9 studies	32% ± 17%	Explore
oligodendrocyte	9 studies	26% ± 10%	Explore
mesothelial cell	9 studies	50% ± 15%	Explore
glutamatergic neuron	9 studies	32% ± 19%	Explore
retinal cone cell	9 studies	77% ± 26%	Explore
type II pneumocyte	8 studies	41% ± 18%	Explore
innate lymphoid cell	8 studies	46% ± 12%	Explore
leukocyte	8 studies	49% ± 9%	Explore
IgG plasma cell	8 studies	39% ± 16%	Explore
T follicular helper cell	8 studies	47% ± 6%	Explore
retinal rod cell	8 studies	55% ± 24%	Explore
club cell	7 studies	59% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	63% ± 15%	Explore
neuron	7 studies	47% ± 20%	Explore
enterocyte	7 studies	53% ± 18%	Explore
IgA plasma cell	7 studies	40% ± 15%	Explore
alveolar macrophage	6 studies	42% ± 12%	Explore
ionocyte	6 studies	51% ± 11%	Explore
neutrophil	6 studies	27% ± 8%	Explore
respiratory goblet cell	6 studies	62% ± 19%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	60% ± 20%	Explore
mononuclear phagocyte	6 studies	49% ± 19%	Explore
epithelial cell of proximal tubule	6 studies	45% ± 14%	Explore
kidney loop of Henle epithelial cell	6 studies	44% ± 13%	Explore
renal alpha-intercalated cell	6 studies	62% ± 9%	Explore
retinal ganglion cell	6 studies	65% ± 29%	Explore
microglial cell	6 studies	30% ± 17%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	61% ± 18%	Explore
CD4-positive helper T cell	5 studies	43% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	48% ± 9%	Explore
exhausted T cell	5 studies	72% ± 13%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	43% ± 12%	Explore
enteroendocrine cell	5 studies	53% ± 23%	Explore
erythroblast	5 studies	46% ± 28%	Explore
transit amplifying cell	5 studies	39% ± 18%	Explore
amacrine cell	5 studies	48% ± 20%	Explore
hematopoietic stem cell	5 studies	30% ± 11%	Explore
lymphocyte	5 studies	64% ± 26%	Explore
T-helper 17 cell	5 studies	65% ± 18%	Explore
mucus secreting cell	5 studies	48% ± 21%	Explore
double negative thymocyte	5 studies	61% ± 19%	Explore
intermediate monocyte	5 studies	67% ± 14%	Explore
granulocyte	5 studies	41% ± 7%	Explore
oligodendrocyte precursor cell	5 studies	30% ± 8%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	41% ± 5%	Explore
hematopoietic precursor cell	4 studies	52% ± 25%	Explore
deuterosomal cell	4 studies	40% ± 12%	Explore
duct epithelial cell	4 studies	62% ± 8%	Explore
squamous epithelial cell	4 studies	52% ± 19%	Explore
glomerular endothelial cell	4 studies	51% ± 13%	Explore
OFF-bipolar cell	4 studies	55% ± 25%	Explore
ON-bipolar cell	4 studies	49% ± 29%	Explore
precursor B cell	4 studies	44% ± 7%	Explore
brush cell	4 studies	36% ± 17%	Explore
immature B cell	4 studies	43% ± 19%	Explore
retina horizontal cell	4 studies	44% ± 19%	Explore
adventitial cell	4 studies	49% ± 8%	Explore
Mueller cell	4 studies	44% ± 10%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	67% ± 6%	Explore
luminal cell of prostate epithelium	4 studies	50% ± 21%	Explore
GABAergic neuron	4 studies	31% ± 14%	Explore
hepatocyte	4 studies	47% ± 29%	Explore
group 3 innate lymphoid cell	4 studies	53% ± 13%	Explore
keratinocyte	4 studies	62% ± 24%	Explore
T-helper 1 cell	4 studies	68% ± 11%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	60% ± 20%	Explore
pancreatic A cell	3 studies	79% ± 16%	Explore
type B pancreatic cell	3 studies	80% ± 15%	Explore
monocyte-derived dendritic cell	3 studies	56% ± 17%	Explore
podocyte	3 studies	41% ± 4%	Explore
intestinal crypt stem cell	3 studies	41% ± 8%	Explore
neural crest cell	3 studies	43% ± 10%	Explore
retinal bipolar neuron	3 studies	62% ± 20%	Explore
GABAergic amacrine cell	3 studies	27% ± 10%	Explore
glycinergic amacrine cell	3 studies	26% ± 8%	Explore
renal principal cell	3 studies	60% ± 3%	Explore
thymocyte	3 studies	46% ± 27%	Explore
extravillous trophoblast	3 studies	69% ± 9%	Explore
placental villous trophoblast	3 studies	60% ± 21%	Explore
megakaryocyte	3 studies	41% ± 5%	Explore
pro-B cell	3 studies	41% ± 6%	Explore
neuroendocrine cell	3 studies	70% ± 19%	Explore
retinal pigment epithelial cell	3 studies	42% ± 26%	Explore
serous secreting cell	3 studies	66% ± 16%	Explore
intraepithelial lymphocyte	3 studies	61% ± 6%	Explore
rod bipolar cell	3 studies	48% ± 11%	Explore
germinal center B cell	3 studies	40% ± 1%	Explore
myoepithelial cell	3 studies	55% ± 14%	Explore
inflammatory macrophage	3 studies	35% ± 10%	Explore
IgM plasma cell	3 studies	47% ± 12%	Explore
muscle cell	3 studies	46% ± 27%	Explore
glial cell	3 studies	44% ± 19%	Explore
interneuron	3 studies	27% ± 8%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	40% ± 10%	Explore
double-positive, alpha-beta thymocyte	3 studies	60% ± 18%	Explore
progenitor cell of mammary luminal epithelium	3 studies	59% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	19 studies	50% ± 13%	Explore
lung	17 studies	55% ± 13%	Explore
intestine	12 studies	43% ± 17%	Explore
brain	12 studies	30% ± 14%	Explore
eye	10 studies	45% ± 22%	Explore
kidney	8 studies	49% ± 14%	Explore
lymph node	6 studies	48% ± 17%	Explore
liver	6 studies	48% ± 25%	Explore
placenta	5 studies	44% ± 23%	Explore
bone marrow	4 studies	37% ± 18%	Explore
uterus	4 studies	68% ± 13%	Explore
prostate	4 studies	39% ± 16%	Explore
breast	4 studies	61% ± 8%	Explore
pancreas	3 studies	74% ± 18%	Explore
heart	3 studies	27% ± 11%	Explore
adrenal gland	3 studies	39% ± 14%	Explore
esophagus	3 studies	58% ± 29%	Explore
skin	3 studies	53% ± 24%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	12237.84	1445 / 1445	100%	95.16	183 / 183
liver	100%	7995.50	226 / 226	100%	123.96	406 / 406
ovary	100%	12846.18	180 / 180	100%	156.97	430 / 430
brain	100%	16897.49	2639 / 2642	100%	146.70	705 / 705
thymus	100%	9922.56	652 / 653	100%	126.64	605 / 605
uterus	100%	10256.63	170 / 170	100%	168.97	458 / 459
stomach	100%	8170.00	359 / 359	100%	121.98	285 / 286
intestine	100%	9267.73	966 / 966	100%	156.26	525 / 527
kidney	100%	11548.39	89 / 89	100%	124.55	897 / 901
skin	100%	15260.71	1808 / 1809	100%	150.23	470 / 472
breast	100%	12265.39	459 / 459	99%	134.72	1112 / 1118
pancreas	100%	6123.86	328 / 328	99%	164.18	177 / 178
prostate	100%	10437.48	245 / 245	99%	112.98	499 / 502
lung	100%	15412.90	577 / 578	99%	132.17	1146 / 1155
bladder	100%	10701.62	21 / 21	99%	144.66	498 / 504
adrenal gland	100%	11689.12	258 / 258	99%	123.11	227 / 230
adipose	100%	12673.55	1204 / 1204	0%	0	0 / 0
blood vessel	100%	14607.57	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	128.28	80 / 80
lymph node	0%	0	0 / 0	100%	132.41	29 / 29
peripheral blood	100%	24648.12	929 / 929	0%	0	0 / 0
spleen	100%	11791.60	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	120.14	45 / 45
ureter	0%	0	0 / 0	100%	172.29	1 / 1
heart	99%	8180.77	856 / 861	0%	0	0 / 0
muscle	97%	4712.70	776 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0046037	Biological process	GMP metabolic process
GO_0016310	Biological process	phosphorylation
GO_0046054	Biological process	dGMP metabolic process
GO_0006163	Biological process	purine nucleotide metabolic process
GO_0006805	Biological process	xenobiotic metabolic process
GO_0015949	Biological process	nucleobase-containing small molecule interconversion
GO_0034436	Biological process	glycoprotein transport
GO_0019673	Biological process	GDP-mannose metabolic process
GO_0006185	Biological process	dGDP biosynthetic process
GO_0046060	Biological process	dATP metabolic process
GO_0046711	Biological process	GDP biosynthetic process
GO_0001917	Cellular component	photoreceptor inner segment
GO_0005829	Cellular component	cytosol
GO_0004385	Molecular function	guanylate kinase activity
GO_0005515	Molecular function	protein binding
GO_0005524	Molecular function	ATP binding

IV. Literature review

[source]

Gene name	GUK1
Protein name	guanylate kinase (EC 2.7.4.8) Guanylate kinase 1 Guanylate kinase (EC 2.7.4.8) (GMP kinase) (Guanylate kinase 1)
Synonyms	GMPK GMK hCG_1984660
Description	FUNCTION: Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) . Involved in the cGMP metabolism in photoreceptors (By similarity). It may also have a role in the survival and growth progression of some tumors . In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine . .
Accessions	ENST00000498092.5 A0A9L9PXH5 A0A9L9PY36 ENST00000366722.5 Q16774 ENST00000366730.5 [Q16774-1] A0A9L9PXQ5 ENST00000366726.5 ENST00000493209.5 ENST00000435153.5 B1ANH0 B1ANG9 ENST00000460224.5 ENST00000465025.1 ENST00000462807.5 A0A9L9PY13 A0A9L9PY17 A0A9L9PY41 ENST00000366723.5 A0A9L9PYH0 ENST00000485083.5 ENST00000492871.5 B1ANH6 ENST00000484953.1 Q96IN2 B1ANH5 ENST00000453943.6 ENST00000312726.9 A0A9L9PXH1 ENST00000453943.6 [Q16774-2] ENST00000485838.5 B1ANH3 Q6IBG8 ENST00000486668.5 A0A9S7JH41 ENST00000366721.5 ENST00000493138.6 ENST00000366728.6 [Q16774-3] A0A9L9PY08

GUK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review