GPX4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0032355Biological processresponse to estradiol
GO_0007283Biological processspermatogenesis
GO_0098869Biological processcellular oxidant detoxification
GO_0019372Biological processlipoxygenase pathway
GO_0110076Biological processnegative regulation of ferroptosis
GO_0051258Biological processprotein polymerization
GO_0042759Biological processlong-chain fatty acid biosynthetic process
GO_0006644Biological processphospholipid metabolic process
GO_0019369Biological processarachidonic acid metabolic process
GO_0006979Biological processresponse to oxidative stress
GO_0005739Cellular componentmitochondrion
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0005635Cellular componentnuclear envelope
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0008430Molecular functionselenium binding
GO_0047066Molecular functionphospholipid-hydroperoxide glutathione peroxidase activity
GO_0004602Molecular functionglutathione peroxidase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGPX4
Protein namephospholipid-hydroperoxide glutathione peroxidase (EC 1.11.1.12) (Glutathione peroxidase 4)
Glutathione peroxidase
Phospholipid hydroperoxide glutathione peroxidase GPX4 (PHGPx) (EC 1.11.1.12) (Glutathione peroxidase 4) (GPx-4) (GSHPx-4) (EC 1.11.1.9)
Synonyms
DescriptionFUNCTION: Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species . The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity). Required for normal sperm development and male fertility (By similarity). Essential for maturation and survival of photoreceptor cells (By similarity). Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity). Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism . Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (By similarity). Can reduce fatty acid-derived hydroperoxides . Can also reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide . .

AccessionsA0A9L9PXS3
Q6PI42
ENST00000706713.1
ENST00000587648.5
ENST00000585362.7
ENST00000611653.4 [P36969-2]
ENST00000593032.6
ENST00000589115.6
A0A0A0MTT1
K7ENB4
Q6PJX4
K7EJ20
ENST00000614791.1
ENST00000585480.1
K7EKX7
ENST00000706715.1
ENST00000588919.5
ENST00000354171.13 [P36969-1]
K7ERP4
R4GNE4
A0A087X247
P36969
ENST00000706714.1