GNAS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071380Biological processcellular response to prostaglandin E stimulus
GO_0009966Biological processregulation of signal transduction
GO_0071107Biological processresponse to parathyroid hormone
GO_0060789Biological processhair follicle placode formation
GO_0046907Biological processintracellular transport
GO_0071880Biological processadenylate cyclase-activating adrenergic receptor signaling pathway
GO_0070527Biological processplatelet aggregation
GO_0007191Biological processadenylate cyclase-activating dopamine receptor signaling pathway
GO_0007608Biological processsensory perception of smell
GO_0009306Biological processprotein secretion
GO_0007565Biological processfemale pregnancy
GO_0040015Biological processnegative regulation of multicellular organism growth
GO_0007190Biological processactivation of adenylate cyclase activity
GO_0071870Biological processcellular response to catecholamine stimulus
GO_0007606Biological processsensory perception of chemical stimulus
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0050890Biological processcognition
GO_0048589Biological processdevelopmental growth
GO_0060348Biological processbone development
GO_0001726Cellular componentruffle
GO_0016324Cellular componentapical plasma membrane
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0030133Cellular componenttransport vesicle
GO_0005834Cellular componentheterotrimeric G-protein complex
GO_0005634Cellular componentnucleus
GO_0031683Molecular functionG-protein beta/gamma-subunit complex binding
GO_0031748Molecular functionD1 dopamine receptor binding
GO_0010856Molecular functionadenylate cyclase activator activity
GO_0005159Molecular functioninsulin-like growth factor receptor binding
GO_0051430Molecular functioncorticotropin-releasing hormone receptor 1 binding
GO_0005525Molecular functionGTP binding
GO_0031698Molecular functionbeta-2 adrenergic receptor binding
GO_0046872Molecular functionmetal ion binding
GO_0035255Molecular functionionotropic glutamate receptor binding
GO_0031852Molecular functionmu-type opioid receptor binding
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameGNAS
Protein nameGuanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas)
Adenylate cyclase-stimulating G alpha protein
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Adenylate cyclase-stimulating G alpha protein)
Neuroendocrine secretory protein 55 (NESP55) [Cleaved into: LHAL tetrapeptide; GPIPIRRH peptide]
GNAS complex locus
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Protein ALEX (Alternative gene product encoded by XL-exon)
GNAS complex locus (cDNA, FLJ79509, highly similar to Guanine nucleotide-binding protein G(s)subunit alpha) (cDNA, FLJ79523, highly similar to Guanine nucleotide-binding protein G(s)subunit alpha)
SynonymsGSP
GNAS1
hCG_1788380
DescriptionFUNCTION: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) . Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP . GNAS functions downstream of several GPCRs, including beta-adrenergic receptors . Stimulates the Ras signaling pathway via RAPGEF2 . .

FUNCTION: May inhibit the adenylyl cyclase-stimulating activity of guanine nucleotide-binding protein G(s) subunit alpha which is produced from the same locus in a different open reading frame. .

FUNCTION: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms (By similarity). .

AccessionsENST00000469431.6
ENST00000371095.7 [P63092-2]
O95467
Q5JWD1
ENST00000461152.6
ENST00000338783.7
ENST00000371085.8 [P63092-1]
ENST00000419558
ENST00000478585.6
ENST00000371075.7 [O95467-1]
A0A590UJQ9
A0A590UJY2
A0A590UK28
A0A8I5F5B5
ENST00000656419.1
ENST00000494081.5
A2A2R6
Q5FWY2
A0A590UJX3
ENST00000453292.7 [O95467-1]
A0A804HIH4
ENST00000371098.6 [O95467-1]
ENST00000467321.6
ENST00000349036.9
ENST00000464624.7
ENST00000482112.6
ENST00000604005.6
ENST00000419558.7 [O95467-1]
ENST00000603546.2
ENST00000464960.5
ENST00000676826.2
Q5JWE9
A0A0S2Z3S5
A0A0A0MR13
ENST00000371081.5
ENST00000488652.6
ENST00000663479.2
ENST00000371102.8 [Q5JWF2-2]
A0A590UJ47
A0A590UJS2
ENST00000491348.5
A0A590UJF0
A0A7I2V5R6
ENST00000467227.6
ENST00000493744.5
ENST00000472183.6
P84996
A0A590UJX6
ENST00000265620.11 [P63092-3]
ENST00000480975.5
ENST00000313949.11 [O95467-1]
ENST00000464788.6
ENST00000488546.6
ENST00000481768
ENST00000470512.6
ENST00000468895.6
ENST00000306090.12
Q5JWF2
ENST00000453292
ENST00000683015.1
A0A0S2Z3H8
ENST00000371100.9 [Q5JWF2-1]
ENST00000481039.6
ENST00000462499.6
ENST00000657090.1
ENST00000354359.12 [P63092-4]
ENST00000682803.1
A0A590UK00
ENST00000492907.6
ENST00000485673.6
ENST00000423897.7
H0Y7E8
P63092
A2A2S1
A0A590UJC9
ENST00000476935.6
ENST00000481768.6 [Q5JWF2-3]
ENST00000667293.2
ENST00000484504.5
ENST00000477931.5
H0Y7Z6
ENST00000306120.4
ENST00000480232.6
B0AZR9
A0A590UJ46