EIF4A2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1990830Biological processcellular response to leukemia inhibitory factor
GO_0002183Biological processcytoplasmic translational initiation
GO_0006446Biological processregulation of translational initiation
GO_0006413Biological processtranslational initiation
GO_1900260Biological processnegative regulation of RNA-dependent RNA polymerase activity
GO_0005829Cellular componentcytosol
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016281Cellular componenteukaryotic translation initiation factor 4F complex
GO_0003743Molecular functiontranslation initiation factor activity
GO_0004386Molecular functionhelicase activity
GO_0005515Molecular functionprotein binding
GO_0003724Molecular functionRNA helicase activity
GO_0016887Molecular functionATP hydrolysis activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameEIF4A2
Protein nameEukaryotic translation initiation factor 4A2
Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2)
Eukaryotic initiation factor 4A-II (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2)
RNA helicase (EC 3.6.4.13)
SynonymshCG_1784041
EIF4F
DDX2B
DescriptionFUNCTION: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.

FUNCTION: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. .

FUNCTION: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. .

FUNCTION: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. .

AccessionsF8WE11
E7EQG2
ENST00000498746.1
Q14240
ENST00000429589.5
ENST00000323963.10 [Q14240-1]
ENST00000443963.5
ENST00000425053.5
ENST00000441007.5
E9PBH4
E7EMV8
J3KSN7
C9JUF0
ENST00000440191.6 [Q14240-2]
ENST00000445596.5
ENST00000426808.5
Q9NZE6