DNAJB6 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	47 studies	37% ± 16%	Explore
natural killer cell	39 studies	42% ± 15%	Explore
fibroblast	38 studies	32% ± 14%	Explore
macrophage	36 studies	39% ± 14%	Explore
CD8-positive, alpha-beta T cell	31 studies	33% ± 12%	Explore
CD4-positive, alpha-beta T cell	31 studies	30% ± 9%	Explore
B cell	30 studies	30% ± 11%	Explore
T cell	30 studies	33% ± 13%	Explore
pericyte	29 studies	35% ± 12%	Explore
smooth muscle cell	28 studies	36% ± 11%	Explore
classical monocyte	23 studies	35% ± 14%	Explore
mast cell	22 studies	35% ± 13%	Explore
endothelial cell of lymphatic vessel	22 studies	31% ± 10%	Explore
conventional dendritic cell	22 studies	37% ± 15%	Explore
monocyte	21 studies	36% ± 14%	Explore
epithelial cell	21 studies	41% ± 23%	Explore
regulatory T cell	21 studies	31% ± 10%	Explore
basal cell	20 studies	45% ± 20%	Explore
non-classical monocyte	20 studies	35% ± 15%	Explore
dendritic cell	19 studies	42% ± 20%	Explore
ciliated cell	17 studies	49% ± 18%	Explore
mature NK T cell	17 studies	36% ± 10%	Explore
memory B cell	16 studies	27% ± 11%	Explore
microglial cell	16 studies	32% ± 15%	Explore
gamma-delta T cell	16 studies	36% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	39% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	35% ± 11%	Explore
astrocyte	15 studies	30% ± 12%	Explore
naive B cell	14 studies	24% ± 8%	Explore
myofibroblast cell	14 studies	34% ± 13%	Explore
connective tissue cell	14 studies	40% ± 10%	Explore
plasmacytoid dendritic cell	14 studies	29% ± 10%	Explore
myeloid cell	14 studies	38% ± 15%	Explore
capillary endothelial cell	13 studies	31% ± 9%	Explore
vein endothelial cell	13 studies	30% ± 10%	Explore
mucosal invariant T cell	13 studies	34% ± 11%	Explore
endothelial cell of vascular tree	13 studies	40% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	25% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	32% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	39% ± 13%	Explore
endothelial cell of artery	11 studies	31% ± 10%	Explore
platelet	10 studies	36% ± 11%	Explore
leukocyte	10 studies	47% ± 18%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	27% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	35% ± 16%	Explore
abnormal cell	10 studies	30% ± 11%	Explore
type I pneumocyte	9 studies	27% ± 8%	Explore
secretory cell	9 studies	47% ± 21%	Explore
mesothelial cell	9 studies	36% ± 17%	Explore
glutamatergic neuron	9 studies	38% ± 20%	Explore
oligodendrocyte	9 studies	29% ± 10%	Explore
hematopoietic stem cell	8 studies	45% ± 11%	Explore
neuron	8 studies	44% ± 21%	Explore
oligodendrocyte precursor cell	8 studies	32% ± 11%	Explore
alveolar macrophage	7 studies	28% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	32% ± 15%	Explore
progenitor cell	7 studies	24% ± 10%	Explore
innate lymphoid cell	7 studies	42% ± 18%	Explore
T follicular helper cell	7 studies	32% ± 10%	Explore
GABAergic neuron	7 studies	38% ± 17%	Explore
mononuclear phagocyte	6 studies	51% ± 14%	Explore
kidney loop of Henle epithelial cell	6 studies	27% ± 8%	Explore
renal alpha-intercalated cell	6 studies	41% ± 11%	Explore
megakaryocyte	6 studies	57% ± 25%	Explore
retinal cone cell	6 studies	38% ± 21%	Explore
lymphocyte	6 studies	38% ± 15%	Explore
precursor B cell	6 studies	34% ± 16%	Explore
plasma cell	6 studies	31% ± 9%	Explore
goblet cell	6 studies	35% ± 19%	Explore
interneuron	6 studies	36% ± 20%	Explore
hematopoietic precursor cell	5 studies	43% ± 20%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	35% ± 15%	Explore
epithelial cell of proximal tubule	5 studies	23% ± 7%	Explore
retinal rod cell	5 studies	35% ± 14%	Explore
pro-B cell	5 studies	29% ± 3%	Explore
club cell	5 studies	33% ± 12%	Explore
cardiac muscle cell	5 studies	26% ± 3%	Explore
granulocyte	5 studies	39% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	27% ± 6%	Explore
respiratory goblet cell	4 studies	28% ± 13%	Explore
pancreatic A cell	4 studies	49% ± 7%	Explore
exhausted T cell	4 studies	33% ± 12%	Explore
glomerular endothelial cell	4 studies	38% ± 16%	Explore
glial cell	4 studies	32% ± 18%	Explore
OFF-bipolar cell	4 studies	45% ± 27%	Explore
ON-bipolar cell	4 studies	44% ± 28%	Explore
retinal ganglion cell	4 studies	79% ± 23%	Explore
brush cell	4 studies	34% ± 13%	Explore
amacrine cell	4 studies	56% ± 21%	Explore
retina horizontal cell	4 studies	43% ± 16%	Explore
retinal pigment epithelial cell	4 studies	40% ± 11%	Explore
adipocyte	4 studies	22% ± 5%	Explore
Mueller cell	4 studies	36% ± 12%	Explore
intermediate monocyte	4 studies	44% ± 22%	Explore
CD4-positive helper T cell	4 studies	38% ± 17%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	40% ± 19%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	55% ± 2%	Explore
muscle cell	4 studies	32% ± 17%	Explore
neutrophil	4 studies	23% ± 6%	Explore
enteroendocrine cell	4 studies	36% ± 18%	Explore
transit amplifying cell	4 studies	28% ± 17%	Explore
keratinocyte	4 studies	52% ± 29%	Explore
T-helper 17 cell	4 studies	32% ± 12%	Explore
deuterosomal cell	3 studies	28% ± 2%	Explore
ionocyte	3 studies	27% ± 12%	Explore
squamous epithelial cell	3 studies	54% ± 18%	Explore
pancreatic D cell	3 studies	38% ± 16%	Explore
type B pancreatic cell	3 studies	49% ± 5%	Explore
plasmablast	3 studies	43% ± 16%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	38% ± 8%	Explore
neural crest cell	3 studies	32% ± 8%	Explore
retinal bipolar neuron	3 studies	49% ± 19%	Explore
GABAergic amacrine cell	3 studies	36% ± 14%	Explore
glycinergic amacrine cell	3 studies	33% ± 14%	Explore
renal principal cell	3 studies	44% ± 13%	Explore
extravillous trophoblast	3 studies	37% ± 5%	Explore
placental villous trophoblast	3 studies	53% ± 18%	Explore
erythroblast	3 studies	36% ± 19%	Explore
immature B cell	3 studies	34% ± 16%	Explore
serous secreting cell	3 studies	31% ± 2%	Explore
tissue-resident macrophage	3 studies	48% ± 19%	Explore
rod bipolar cell	3 studies	35% ± 11%	Explore
chondrocyte	3 studies	24% ± 11%	Explore
germinal center B cell	3 studies	25% ± 5%	Explore
luminal cell of prostate epithelium	3 studies	56% ± 5%	Explore
type II pneumocyte	3 studies	26% ± 11%	Explore
pancreatic ductal cell	3 studies	52% ± 10%	Explore
ependymal cell	3 studies	33% ± 14%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	56% ± 22%	Explore
intestinal crypt stem cell	3 studies	22% ± 4%	Explore
adventitial cell	3 studies	25% ± 11%	Explore
group 3 innate lymphoid cell	3 studies	50% ± 20%	Explore
melanocyte	3 studies	30% ± 9%	Explore
double negative thymocyte	3 studies	53% ± 20%	Explore
myoepithelial cell	3 studies	50% ± 13%	Explore
progenitor cell of mammary luminal epithelium	3 studies	57% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	37% ± 14%	Explore
peripheral blood	17 studies	31% ± 13%	Explore
brain	15 studies	32% ± 14%	Explore
intestine	10 studies	29% ± 13%	Explore
kidney	9 studies	30% ± 9%	Explore
eye	9 studies	38% ± 14%	Explore
heart	5 studies	21% ± 3%	Explore
lymph node	5 studies	29% ± 7%	Explore
pancreas	4 studies	43% ± 13%	Explore
placenta	4 studies	42% ± 7%	Explore
bone marrow	4 studies	24% ± 5%	Explore
uterus	4 studies	42% ± 10%	Explore
breast	4 studies	50% ± 5%	Explore
liver	4 studies	43% ± 12%	Explore
esophagus	3 studies	41% ± 24%	Explore
prostate	3 studies	63% ± 7%	Explore
adipose	3 studies	20% ± 3%	Explore
skin	3 studies	44% ± 19%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	6253.00	459 / 459	100%	28.52	1118 / 1118
esophagus	100%	8044.44	1445 / 1445	100%	21.26	183 / 183
intestine	100%	7435.30	966 / 966	100%	18.49	527 / 527
uterus	100%	6810.32	170 / 170	100%	23.26	459 / 459
lung	100%	5580.35	577 / 578	100%	22.17	1155 / 1155
bladder	100%	7347.10	21 / 21	100%	20.56	503 / 504
prostate	100%	5094.29	245 / 245	100%	14.32	501 / 502
ovary	100%	5282.32	180 / 180	100%	19.30	429 / 430
skin	100%	8034.28	1809 / 1809	100%	26.24	470 / 472
stomach	99%	4325.85	357 / 359	100%	16.81	286 / 286
thymus	100%	4546.46	652 / 653	99%	15.58	601 / 605
brain	99%	4924.47	2621 / 2642	100%	21.34	704 / 705
kidney	100%	4194.72	89 / 89	99%	15.66	891 / 901
adrenal gland	100%	4317.78	258 / 258	97%	15.31	224 / 230
liver	90%	2015.55	203 / 226	97%	10.08	395 / 406
pancreas	84%	1784.19	276 / 328	99%	17.65	176 / 178
adipose	100%	6378.49	1204 / 1204	0%	0	0 / 0
blood vessel	100%	9847.73	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	19.33	29 / 29
muscle	100%	18658.06	803 / 803	0%	0	0 / 0
spleen	100%	5093.04	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	22.73	45 / 45
ureter	0%	0	0 / 0	100%	5.35	1 / 1
heart	98%	7770.97	848 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	98%	13.73	78 / 80
peripheral blood	92%	4010.36	852 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0043154	Biological process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0090084	Biological process	negative regulation of inclusion body assembly
GO_0060717	Biological process	chorion development
GO_0061077	Biological process	chaperone-mediated protein folding
GO_0032880	Biological process	regulation of protein localization
GO_0060710	Biological process	chorio-allantoic fusion
GO_0030198	Biological process	extracellular matrix organization
GO_1900034	Biological process	regulation of cellular response to heat
GO_0006457	Biological process	protein folding
GO_0045109	Biological process	intermediate filament organization
GO_0030036	Biological process	actin cytoskeleton organization
GO_0034504	Biological process	protein localization to nucleus
GO_0060715	Biological process	syncytiotrophoblast cell differentiation involved in labyrinthine layer development
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0016020	Cellular component	membrane
GO_0030018	Cellular component	Z disc
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0044183	Molecular function	protein folding chaperone
GO_0031072	Molecular function	heat shock protein binding
GO_0051082	Molecular function	unfolded protein binding
GO_0051087	Molecular function	protein-folding chaperone binding
GO_0030544	Molecular function	Hsp70 protein binding
GO_0005515	Molecular function	protein binding
GO_0001671	Molecular function	ATPase activator activity

IV. Literature review

[source]

Gene name	DNAJB6
Protein name	Uncharacterized protein DNAJB6 DnaJ homolog subfamily B member 6 (HHDJ1) (Heat shock protein J2) (HSJ-2) (MRJ) (MSJ-1) DNAJB6 protein DnaJ heat shock protein family (Hsp40) member B6
Synonyms	MRJ HSJ2 MSJ1
Description	FUNCTION: Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70 . Plays an indispensable role in the organization of KRT8/KRT18 filaments . Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin . Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins . Also reduces cellular toxicity and caspase-3 activity . .; FUNCTION: [Isoform B]: Isoform B but not isoform A inhibits huntingtin aggregation. .
Accessions	C9JB42 ENST00000262177.9 [O75190-1] C9J2P2 Q75MP3 F8WCZ4 ENST00000453383.5 ENST00000634080.1 C9JDX6 C9J2C4 E9PH18 Q49A72 ENST00000429029.6 [O75190-2] ENST00000441561.5 ENST00000412557.5 ENST00000443280.5 ENST00000439402.1 ENST00000437030.5 C9JDR7 C9JN01 O75190 ENST00000459889.5 ENST00000441291.5 A0A0J9YX62 ENST00000417758.5

DNAJB6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review