DDX21 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016479Biological processnegative regulation of transcription by RNA polymerase I
GO_0045087Biological processinnate immune response
GO_0001649Biological processosteoblast differentiation
GO_0002735Biological processpositive regulation of myeloid dendritic cell cytokine production
GO_0043330Biological processresponse to exogenous dsRNA
GO_0051607Biological processdefense response to virus
GO_0006338Biological processchromatin remodeling
GO_0045945Biological processpositive regulation of transcription by RNA polymerase III
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0045943Biological processpositive regulation of transcription by RNA polymerase I
GO_0062176Biological processR-loop processing
GO_0006364Biological processrRNA processing
GO_0005730Cellular componentnucleolus
GO_0110016Cellular componentB-WICH complex
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005694Cellular componentchromosome
GO_0019843Molecular functionrRNA binding
GO_0003724Molecular functionRNA helicase activity
GO_0042802Molecular functionidentical protein binding
GO_0003729Molecular functionmRNA binding
GO_0030515Molecular functionsnoRNA binding
GO_0097322Molecular function7SK snRNA binding
GO_0140870Molecular functionRNA polymerase inhibitor activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0035198Molecular functionmiRNA binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene nameDDX21
Protein nameRNA helicase (EC 3.6.4.13)
DDX21 protein
Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu)
Synonyms
DescriptionFUNCTION: RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) . Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs . In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes . In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes . Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' . Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) . Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases . Involved in rRNA processing . May bind to specific miRNA hairpins . Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). .

AccessionsENST00000354185.9 [Q9NR30-1]
Q3SWU7
ENST00000690316.1 [Q9NR30-2]
A0A8I5KYZ4
Q9NR30
ENST00000690650.1
A0A8I5KND9
A0A8I5KNN2
ENST00000684824.1
ENST00000685106.1
ENST00000686528.1
A0A8I5KNP3
ENST00000620315.2 [Q9NR30-2]